Search Results - "Do Sacramento, Valentin"
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Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy
Published in The Journal of experimental medicine (04-12-2023)“…Targeted eradication of transformed or otherwise dysregulated cells using monoclonal antibodies (mAb), antibody-drug conjugates (ADC), T cell engagers (TCE),…”
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AHR:IKAROS Interaction Promotes Platelet Biogenesis in Response to SR1
Published in Reports (MDPI) (01-03-2021)“…In vitro, the differentiation of megakaryocytes (MKs) is improved by aryl-hydrocarbon receptor (AHR) antagonists such as StemRegenin 1 (SR1), an effect…”
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Development of an efficient, ready to use, blood platelet-release device based on two new flow regime parameters: The periodic hydrodynamic loading and the shear stress accumulation
Published in New biotechnology (25-11-2023)“…In vitro production of blood platelets for transfusion purposes is gaining interest. While platelet production is now possible on a laboratory scale, the…”
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Engineered Single Amino Acid Substitutions Protect Hematopoietic Stem and Progenitor Cells from CD123 Targeted Immunotherapy
Published in Blood (15-11-2022)Get full text
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Function-Preserving Single Amino Acid Substitutions Shield Hematopoietic Stem and Progenitor Cells from CD117 Targeted Immunotherapy In Vivo
Published in Blood (15-11-2022)Get full text
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Functional properties of human platelets derived in vitro from CD34+ cells
Published in Scientific reports (22-01-2020)“…The in vitro production of blood platelets for transfusion purposes is an important goal in the context of a sustained demand for controlled products free of…”
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