Search Results - "Doğruer, Deniz S"

Synthesis and antimicrobial activity of new 1,2,4-triazole and 1,3,4-thiadiazole derivatives by Onkol, Tijen, Doğruer, Deniz S, Uzun, Leyla, Adak, Selcen, Ozkan, Semiha, Sahin, M Fethi

“…In this study, new 3-[(1(2H)-phthalazinone-2-yl(methyl/ethyl]-4-aryl-1,2,4-triazole-5-thione and…”
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Synthesis and evaluation of multitarget new 2‐aminothiazole derivatives as potential anti‐Alzheimer's agents by Bardakkaya, Merve, Kilic, Burcu, Sagkan, Rahsan Ilıkcı, Aksakal, Fatma, Shakila, Shakila, Dogruer, Deniz S.

“…In this study, two diverse series of 2‐aminothiazole‐based multitarget compounds, one propenamide and the other propanamide derivatives, were designed and…”
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1-[4-(4-Chloro-phen-yl)piperazin-1-yl]-3-(6-oxo-3,4-diphenyl-1,6-dihydro-pyridazin-1-yl)propan-1-one by Aydın, Abdullah, Akkurt, Mehmet, Doğruer, Deniz S, Büyükgüngör, Orhan

“…In the title compound, C(29)H(27)ClN(4)O(2), the six-membered ring of the pyridazine group is nearly planar [maximum deviation = -0.062 (2) Å] and its mean…”
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Synthesis and antimicrobial activity of some 3(2H)-pyridazinone and 1(2H)-phthalazinone derivatives by ÖNKOL, Tijen, ŞAHİN, M. Fethi, DOĞRUER, Deniz S, ÖZKAN, Semiha, ÖZGEN, Selda

“…Some 3(2H)-pyridazinone and 1(2H)-phthalazinone derivatives were synthesized. The structures of these new compounds were confirmed by IR, $^1H$-NMR, mass…”
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Synthesis of some 3(2H)-pyridazinone and 1(2H)-phthalazinone derivatives incorporating aminothiazole moiety and investigation of their antioxidant, acetylcholinesterase, and butyrylcholinesterase inhibitory activities by Yamalı, Cem, Ozan Gülcan, H., Kahya, Burcu, Çobanoğlu, Simla, Kadir Şüküroğlu, M., Doğruer, Deniz S.

“…In this study, 12 new compounds were synthesized, six of which were 3(2 H )-pyridazinone ( 9a – f ) and the others were 1(2 H )-phthalazinone ( 10a–f )…”
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Design, Synthesis and Investigation of New Diphenyl Substituted Pyridazinone Derivatives as Both Cholinesterase and Aβ-Aggregation Inhibitors by Kilic, Burcu, Erdogan, Merve, Gulcan, Hayrettin O, Aksakal, Fatma, Oruklu, Nihan, Bagriacik, Emin U, Dogruer, Deniz S

“…With respect to the increase in the average life expectancy, Alzheimer Disease (AD), the most common form of age-related dementia, has become a major threat to…”
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Synthesis and investigation of the cholinesterase inhibitory and antioxidant capacities of some novel N'‐(quinolin‐4‐ylmethylene)propanehydrazides against Alzheimer's disease by Kilic, Burcu, Dogruer, Deniz S.

“…One of the worst long‐term health issues of the past few decades is Alzheimer's disease (AD). Unfortunately, there are currently insufficient choices for…”
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Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity by DOĞRUER, DENİZ S., URLU, ŞÖLEN, ÖNKOL, TİJEN, ÖZÇELİK, BERRİN, ŞAHİN, M. FETHİ

“…Some pyridazine derivatives carrying urea, thiourea, and sulfonamide groups were synthesized and evaluated for their antimicrobial activity against…”
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Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer’s disease by Erdogan, Merve, Kilic, Burcu, Sagkan, Rahsan Ilıkcı, Aksakal, Fatma, Ercetin, Tugba, Gulcan, Hayrettin O., Dogruer, Deniz S.

“…In this study, four series of compounds with benzoxazolone and benzothiazolone cores were designed, synthesized and evaluated as multifunctional agents against…”
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Crystal Structure of 1-[2-[6-(4-Methoxyphenyl)-3(2H)-pyridazinone-2-yl]acetyl]-4-(2-pyridyl)piperazine by INGEÇ, Sebnem Kandil, SOYLU, Hüseyin, KENDI, Engin, DOGRUER, Deniz S., SAHIN, M. Fethi

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New thiourea and benzamide derivatives of 2-aminothiazole as multi-target agents against Alzheimer's disease: Design, synthesis, and biological evaluation by Kilic, Burcu, Bardakkaya, Merve, Ilıkcı Sagkan, Rahsan, Aksakal, Fatma, Shakila, Shakila, Dogruer, Deniz S.

“…[Display omitted] •Thiourea and benzamide derivatives of 2-aminothiazole were synthesized as anti-AD agents.•Some of the compounds were found as antioxidant,…”
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Synthesis and analgesic and anti-inflammatory activity of new pyridazinones by ŞAHİN, M. Fethi, DOĞRUER, Deniz S, KÜPELİ, Esra, YEŞİLADA, Erdem

“…A new series of 2-(6-oxo-3,5-diphenyl-6H-pyridazin-l-yl)-acetamides and 3-[6-oxo-3,5-diphenyl-6H-pyridazin-l-yl)-propanamides were synthesized and evaluated in…”
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Design and synthesis of some new carboxamide and propanamide derivatives bearing phenylpyridazine as a core ring and the investigation of their inhibitory potential on in-vitro acetylcholinesterase and butyrylcholinesterase by Kilic, Burcu, Gulcan, Hayrettin O., Aksakal, Fatma, Ercetin, Tugba, Oruklu, Nihan, Umit Bagriacik, E., Dogruer, Deniz S.

“…[Display omitted] •Carboxamide/propanamide derivatives of phenylpyridazine/biphenyl were synthesized.•Most of the carboxamide derivatives were selective for…”
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2-[2-(4-Benzylpiperazin-1-ylcarbonyl)ethyl]-5,6-diphenylpyridazin-3(2 H )-one by Aydın, Abdullah, Doğruer, Deniz S., Akkurt, Mehmet, Büyükgüngör, Orhan

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Synthesis of New 2-[1(2H)-Phthalazinon-2-yl]acetamide and 3-[1(2H)-Phthalazinon-2-yl]propanamide Derivatives as Antinociceptive and Anti-inflammatory Agents by Dogruer, Deniz S., Kupeli, Esra, Yesilada, Erdem, Sahin, M. Fethi

“…As a consequence of our ongoing studies on heterocyclic compounds for new antinociceptive and anti‐inflammatory agents bearing lactam functional group, new…”
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2-[2-(4-Benzyl-piperazin-1-ylcarbon-yl)eth-yl]-5,6-diphenyl-pyridazin-3(2H)-one by Aydın, Abdullah, Doğruer, Deniz S, Akkurt, Mehmet, Büyükgüngör, Orhan

“…The title compound, C(30)H(30)N(4)O(2), has a non-planar conformation, the dihedral angles formed by the pyridazinone ring plane and the three phenyl rings…”
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Multifunctional anti-Alzheimer's agents: Synthesis, biological evaluation, and molecular docking study of new 2-phenoxyacetamide/3-phenoxypropanamide/4-oxobutanamide derivatives by Shakila, Shakila, Kilic, Burcu, Bardakkaya, Merve, Aksakal, Fatma, Sagkan, Rahsan Ilikci, Dogruer, Deniz S.

“…•Three novel series were designed, synthesized, and evaluated as anti-AD agents.•4b emerged as a lead candidate against BChE.•4b has the best neuroprotective…”
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Synthesis of some new 2,6-disubstituted-3(2H)-pyridazinone derivatives and investigation of their analgesic, anti-inflammatory and antimicrobial activities by Tiryaki, Didem, Sukuroglu, Murat, Dogruer, Deniz S., Akkol, Esra, Ozgen, Selda, Sahin, M. Fethi

“…In this study, 12 new 3(2 H )-pyridazinone derivatives carrying 4-substituted phenylpiperazinylethyl moiety on lactam nitrogen were synthesized and their…”
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Synthesis of 2-(5,6-diphenyl-3(2h)-pyridazinone-2- yl) acetamide and 3-(5,6-diphenly-3(2H)-pyridazinone-2-yl)propanamide derivatives as analgesic and anti-inflammatory agents by DOĞRUER, Deniz S, KÜPELİ, Esra, ŞAHİN, M. Fethi, BANOĞLU, Erden, ÜNLÜ, Serdar

“…Bu çalışmada, onaltı yeni 2-[5,6-difenil-3(2H)-piridazinon-2-il] asetamit ve 3-[5,6-difenil-3(2H)-piridazinon-2-il] propanamit türevleri sentez edilmiş ve…”
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Studies on Some 3(2H)-Pyridazinone Derivatives with Antinociceptive Activity by Dogruer, Deniz S., Fethi Sahin, M., ünlü, Serdar, Ito, Shigeru

“…Nineteen new [6‐(4‐methoxyphenyl)‐3(2H)‐pyridazinone‐2‐yl]‐acetamide (1—10) and 3‐[6‐(4‐methoxyphenyl)‐3(2H)‐pyridazinone‐2‐yl]propanamide (11—19) derivatives…”
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