Search Results - "Do, Zung N."

Pharmacokinetics and Pharmacodynamics of AR9281, an Inhibitor of Soluble Epoxide Hydrolase, in Single- and Multiple-Dose Studies in Healthy Human Subjects by Chen, Dawn, Whitcomb, Randall, MacIntyre, Euan, Tran, Vinh, Do, Zung N., Sabry, James, Patel, Dinesh V., Anandan, Sampath K., Gless, Richard, Webb, Heather K.

“…AR9281, a potent and selective inhibitor of soluble epoxide hydrolase (s-EH), is in clinical development targeting hypertension and type 2 diabetes. The…”
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1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia by Anandan, Sampath-Kumar, Webb, Heather Kay, Chen, Dawn, Wang, Yi-Xin (Jim), Aavula, Basker R., Cases, Sylvaine, Cheng, Ying, Do, Zung N., Mehra, Upasana, Tran, Vinh, Vincelette, Jon, Waszczuk, Joanna, White, Kathy, Wong, Kenneth R., Zhang, Le-Ning, Jones, Paul D., Hammock, Bruce D., Patel, Dinesh V., Whitcomb, Randall, MacIntyre, D. Euan, Sabry, James, Gless, Richard

“…1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) attenuated the enhanced glucose excursion following an intraperitoneal glucose tolerance test and…”
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Non-urea functionality as the primary pharmacophore in soluble epoxide hydrolase inhibitors by Anandan, Sampath-Kumar, Do, Zung N., Webb, Heather K., Patel, Dinesh V., Gless, Richard D.

“…Inhibition of soluble epoxide hydrolase (sEH) has been proposed as a promising new pharmaceutical target for diseases involving hypertension and vascular…”
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Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase by Jones, Paul D., Tsai, Hsing-Ju, Do, Zung N., Morisseau, Christophe, Hammock, Bruce D.

“…A series of conformationally restricted inhibitors of human soluble epoxide hydrolase (sEH) has been developed. Inhibition potency of the described compounds…”
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CHARACTERIZATION OF CELL LINES DEVELOPED FROM THE GLASSY-WINGED SHARPSHOOTER, HOMALODISCA COAGULATA (HEMIPTERA: CICADELLIDAE) by KAMITA, SHIZUO G, DO, ZUNG N, SAMRA, AMAN I, HAGLER, JAMES R, HAMMOCK, BRUCE D

“…Four continuous cell lines were established from the embryos of the glassy-winged sharpshooter, Homalodisca coagulata (Say), an economically important insect…”
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Unsymmetrical non-adamantyl N,N′-diaryl urea and amide inhibitors of soluble expoxide hydrolase by Anandan, Sampath-Kumar, Webb, Heather K., Do, Zung N., Gless, Richard D.

“…We explored replacement of an adamantyl R group in the aryl ether scaffold 1 with substituted aryl rings to identify equipotent, and metabolically stable sEH…”
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Unsymmetrical non-adamantyl N,Nâ(tm)-diaryl urea and amide inhibitors of soluble expoxide hydrolase by Anandan, Sampath-Kumar, Webb, Heather K, Do, Zung N, Gless, Richard D

“…Incorporation of an adamantyl group in prototypical soluble expoxide hydrolase (sEH) inhibitors afforded improved enzyme potency. We explored replacement of…”
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