Search Results - "Dmitry V. Kravchenko"

The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2 by Ivashchenko, Andrey A, Zagribelnyy, Bogdan A, Ivanenkov, Yan A, Ivashchenko, Ilya A, Karapetian, Ruben N, Kravchenko, Dmitry V, Savchuk, Nikolay P, Yakubova, Elena V, Ivachtchenko, Alexandre V

“…The efficacy of aprotinin combinations with selected antiviral-drugs treatment of influenza virus and coronavirus (SARS-CoV-2) infection was studied in mice…”
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Safety and efficacy of aviandr in patients with generalized anxiety disorder: A multicenter, randomized, double-blind, placebo-controlled, dose-finding, pilot study by Ivashchenko, Andrey A., Morozova, Margarita A., Vostokova, Natalia V., Beniashvily, Allan G., Bukhanovskaya, Olga A., Burminskiy, Denis S., Egorova, Alina N., Gluskina, Lubov Y., Gorchakov, Dmitriy S., Karapetian, Ruben N., Kasimova, Lala N., Kravchenko, Dmitry V., Lepilkina, Taissia A., Merkulova, Elena A., Mitkin, Oleg D., Penchul, Nataliya A., Potanin, Sergey S., Rupchev, George E., Ivachtchenko, Alexandre V.

“…Generalized anxiety disorder (GAD) is associated with an imbalance in the functioning of the stimulating neurotransmitter systems in human's brain. We studied…”
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Methylation of Methyl 4-Hydroxy-2-thioxo-1,2-dihydroquinoline-3-carboxylate: Synthetic, Crystallographic, and Molecular Docking Studies by Kovalenko, Sergiy M, Drushlyak, Oleksandr G, Shishkina, Svitlana V, Konovalova, Irina S, Mariutsa, Illia O, Bunyatyan, Natalya D, Kravchenko, Dmitry V, Ivanov, Vladimir V, Ivachtchenko, Alexandre V, Langer, Thierry

“…Consecutive alkylation of 4-hydroxy-2-thioxo-1,2-dihydroquinoline-3-carboxylate by CH I has been investigated to establish regioselectivity of the reaction for…”
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Effect of Aprotinin and Avifavir® Combination Therapy for Moderate COVID-19 Patients by Ivashchenko, Andrey A., Azarova, Valeria N., Egorova, Alina N., Karapetian, Ruben N., Kravchenko, Dmitry V., Krivonos, Natalia V., Loginov, Vladimir G., Poyarkov, Stanislav V., Merkulova, Elena A., Rosinkova, Olga S., Savchuk, Nikolay P., Topr, Mikhail A., Simakina, Elena N., Yakubova, Elena V., Ivachtchenko, Alexandre V.

“…COVID-19 is a contagious multisystem inflammatory disease caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We studied the efficacy of…”
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Crystal structure of the non-steroidal anti-inflammatory drug (NSAID) tolmetin sodium by Konovalova, Irina S, Kovalenko, Sergiy M, Kravchenko, Dmitry V, Chuev, Vladimir P

“…The asymmetric unit of the title compound, sodium 2-[1-methyl-5-(4-methyl-benzo-yl)-1 -pyrrol-2-yl]acetate dihydrate, Na ·C H NO ·2H O, contains two sodium…”
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Synthesis, X-Ray Crystal Structure, Hirshfeld Surface Analysis, and Molecular Docking Study of Novel Hepatitis B (HBV) Inhibitor: 8-Fluoro-5-(4-fluorobenzyl)-3-(2-methoxybenzyl)-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one by Ivashchenko, Aleksandr V., Mitkin, Oleg D., Kravchenko, Dmitry V., Kuznetsova, Irina V., Kovalenko, Sergiy M., Bunyatyan, Natalya D., Langer, Thierry

“…A method for the synthesis of 8-fluoro-5-(4-fluorobenzyl)-3-(2-methoxybenzyl)-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one has been developed and the electronic…”
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Novel One-Pot Synthesis of Methyl 4-Hydroxy-2-thioxo-1,2-dihydroquinoline-3-carboxylate: Synthetic and Crystallographic Studies by Kovalenko, Sergiy M., Drushlyak, Oleksandr G., Konovalova, Irina S., Mariutsa, Illia O., Kravchenko, Dmitry V., Ivachtchenko, Alexandre V., Mitkin, Oleg D.

“…A new suitable method of synthesis of methyl 4-hydroxy-2-thioxo-1,2-dihydroquinoline-3-carboxylate by condensation of methyl 2-isothiocyanatobenzoate and…”
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Synthesis, X-ray crystal structure, Hirshfeld surface analysis, and molecular docking study of novel inhibitor of hepatitis B: methyl 4-fluoro-3-(morpholinosulfonyl)benzo[b]thiophene-2-carboxylate by Ivachtchenko, Alexandre V., Mitkin, Oleg D., Kravchenko, Dmitry V., Kovalenko, Sergiy M., Shishkina, Svitlana V., Bunyatyan, Natalya D., Konovalova, Irina S., Dmitrieva, Irina G., Ivanov, Vladimir V., Langer, Thierry

“…A method of 4-fluoro-3-(morpholinosulfonyl)benzo[b]thiophene-2-carboxylate synthesis has been developed and the electronic and spatial structure of a new…”
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AVIFAVIR for Treatment of Patients With Moderate Coronavirus Disease 2019 (COVID-19): Interim Results of a Phase II/III Multicenter Randomized Clinical Trial by Ivashchenko, Andrey A, Dmitriev, Kirill A, Vostokova, Natalia V, Azarova, Valeria N, Blinow, Andrew A, Egorova, Alina N, Gordeev, Ivan G, Ilin, Alexey P, Karapetian, Ruben N, Kravchenko, Dmitry V, Lomakin, Nikita V, Merkulova, Elena A, Papazova, Natalia A, Pavlikova, Elena P, Savchuk, Nikolay P, Simakina, Elena N, Sitdekov, Tagir A, Smolyarchuk, Elena A, Tikhomolova, Elena G, Yakubova, Elena V, Ivachtchenko, Alexandre V

“…In May 2020 the Russian Ministry of Health granted fast-track marketing authorization to RNA polymerase inhibitor AVIFAVIR (favipiravir) for the treatment of…”
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Non-rigid Diarylmethyl Analogs of Baloxavir as Cap-Dependent Endonuclease Inhibitors of Influenza Viruses by Ivashchenko, Andrei A, Mitkin, Oleg D, Jones, Jeremy C, Nikitin, Alexander V, Koryakova, Angela G, Ryakhovskiy, Alexey, Karapetian, Ruben N, Kravchenko, Dmitry V, Aladinskiy, Vladimir, Leneva, Irina A, Falynskova, Irina N, Glubokova, Ekaterina A, Govorkova, Elena A, Ivachtchenko, Alexandre V

“…4-Substituted 2,4-dioxobutanoic acids inhibit influenza virus cap-dependent endonuclease (CEN) activity. Baloxavir marboxil, 4, is approved for treating…”
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Synthesis, inhibitory activity and oral dosing formulation of AV5124, the structural analogue of influenza virus endonuclease inhibitor baloxavir by Ivashchenko, Andrei A, Mitkin, Oleg D, Jones, Jeremy C, Nikitin, Alexander V, Koryakova, Angela G, Karapetian, Ruben N, Kravchenko, Dmitry V, Mochalov, Stephan V, Ryakhovskiy, Alexey A, Aladinskiy, Vladimir, Leneva, Irina A, Falynskova, Irina N, Glubokova, Ekaterina A, Govorkova, Elena A, Ivachtchenko, Alexandre V

“…Abstract Background The development and clinical implementation of the cap-dependent endonuclease (CEN) inhibitor baloxavir marboxil was a breakthrough in…”
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Synthesis, biological evaluation and in silico modeling of novel integrase strand transfer inhibitors (INSTIs) by Ivashchenko, Andrey A., Ivanenkov, Yan A., Koryakova, Angela G., Karapetian, Ruben N., Mitkin, Oleg D., Aladinskiy, Vladimir A., Kravchenko, Dmitry V., Savchuk, Nikolai P., Ivashchenko, Alexander V.

“…Although a relatively wide range of therapeutic options is currently available for the treatment of HIV/AIDS, it is still among the most serious and virulent…”
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Synthesis, biological evaluation and in silico modeling of novel pan-genotypic NS5A inhibitors by Ivashchenko, Andrey A., Ivanenkov, Yan A., Aladinskiy, Vladimir A., Karapetian, Ruben N., Koryakova, Angela G., Ryakhovskiy, Alexey A., Mitkin, Oleg D., Kravchenko, Dmitry V., Savchuk, Nikolai P., Zagribelnyy, Bogdan A., Ivashchenko, Alexander V.

“…[Display omitted] •Novel picomolar pan-genotypic NS5A inhibitors.•Combinatorial synthesis, biological evaluation and in silico modeling.•Lead compound showed…”
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Blastic Plasmacytoid Dendritic Cell Neoplasm by Kravchenko, Dmitry V, Zinovkin, Dmitry A, Davydov, Denis A, Kisialeu, Pavel G, Kopschaj, Pavel A, Savchenko, Oleg, Savchenko, Mariya, Barauniova, Maryna V, Portyanko, Anna S, Pranjol, Md Zahidul Islam

“…NONE…”
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Design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists by Ivachtchenko, Alexandre V., Ivanenkov, Yan A., Mitkin, Oleg D., Vorobiev, Anton A., Kuznetsova, Irina V., Shevkun, Natalia A., Koryakova, Angela G., Karapetian, Ruben N., Trifelenkov, Andrey S., Kravchenko, Dmitry V., Veselov, Mark S., Chufarova, Nina V.

“…A series of novel highly active androgen receptor (AR) antagonists containing…”
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Highly sensitive field test lateral flow immunodiagnostics of PVX infection by Drygin, Yuri F., Blintsov, Anatoly N., Grigorenko, Vitaly G., Andreeva, Irina P., Osipov, Alexander P., Varitzev, Yuri A., Uskov, Alexander I., Kravchenko, Dmitry V., Atabekov, Joseph G.

“…A test system is described and expanded upon for mass field immunochromatography assay on porous membrane carriers for rapid diagnostics of potato virus X…”
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(1 R ,3 S )-3-(1 H -Benzo[ d ]imidazol-2-yl)-1,2,2-tri-methyl-cyclo-pentane-1-carb-oxy-lic acid as a new anti-diabetic active pharmaceutical ingredient by Kovalenko, Sergiy M, Konovalova, Irina S, Merzlikin, Sergiy I, Chuev, Vladimir P, Kravchenko, Dmitry V

“…The chiral title compound, C H N O , which can be used for producing active pharmaceutical ingredients for treatment of type 2 pancreatic diabetes and other…”
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Synthesis of 7-arylimidazo[1,2-a]pyrazin-8(7H)-one derivatives by Kovalenko, Svitlana S., Drushlyak, Oleksandr G., Kovalenko, Sergiy M., Bunyatyan, Natalya D., Kravchenko, Dmitry V., Ivachtchenko, Alexandre V.

“…A suitable approach to the synthesis of 7-arylimidazo[1,2- a ]pyrazin-8(7 H )-ones starting from esters of oxalic acid monoamides via cyclization of…”
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(1 R ,3 S )-3-(1 H -Benzo[ d ]imidazol-2-yl)-1,2,2-trimethylcyclopentane-1-carboxylic acid as a new anti-diabetic active pharmaceutical ingredient by Kovalenko, Sergiy M., Konovalova, Irina S., Merzlikin, Sergiy I., Chuev, Vladimir P., Kravchenko, Dmitry V.

“…The chiral title compound, C 16 H 20 N 2 O 2 , which can be used for producing active pharmaceutical ingredients for treatment of type 2 pancreatic diabetes…”
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Discovery of Novel Highly Potent Hepatitis C Virus NS5A Inhibitor (AV4025) by Ivachtchenko, Alexandre V, Mitkin, Oleg D, Yamanushkin, Pavel M, Kuznetsova, Irina V, Bulanova, Elena A, Shevkun, Natalia A, Koryakova, Angela G, Karapetian, Ruben N, Bichko, Vadim V, Trifelenkov, Andrey S, Kravchenko, Dmitry V, Vostokova, Natalia V, Veselov, Mark S, Chufarova, Nina V, Ivanenkov, Yan A

“…A series of next in class small-molecule hepatitis C virus (HCV) NS5A inhibitors with picomolar potency containing…”
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