Search Results - "Dmitriev, Sergey E"

Translation of 5' leaders is pervasive in genes resistant to eIF2 repression by Andreev, Dmitry E, O'Connor, Patrick B F, Fahey, Ciara, Kenny, Elaine M, Terenin, Ilya M, Dmitriev, Sergey E, Cormican, Paul, Morris, Derek W, Shatsky, Ivan N, Baranov, Pavel V

“…Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions. This can be achieved by the phosphorylation-mediated inactivation…”
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RNA-seq analysis of an apical meristem time series reveals a critical point in Arabidopsis thaliana flower initiation by Klepikova, Anna V, Logacheva, Maria D, Dmitriev, Sergey E, Penin, Aleksey A

“…Floral transition is a critical event in the life cycle of a flowering plant as it determines its reproductive success. Despite extensive studies of specific…”
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Patterns of Aging Biomarkers, Mortality, and Damaging Mutations Illuminate the Beginning of Aging and Causes of Early-Life Mortality by Kinzina, Elvira D., Podolskiy, Dmitriy I., Dmitriev, Sergey E., Gladyshev, Vadim N.

“…An increase in the probability of death has been a defining feature of aging, yet human perinatal mortality starts high and decreases with age. Previous…”
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Functional Cyclization of Eukaryotic mRNAs by Alekhina, Olga M, Terenin, Ilya M, Dmitriev, Sergey E, Vassilenko, Konstantin S

“…The closed-loop model of eukaryotic translation states that mRNA is circularized by a chain of the cap-eIF4E-eIF4G-poly(A)-binding protein (PABP)-poly(A)…”
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svist4get: a simple visualization tool for genomic tracks from sequencing experiments by Egorov, Artyom A, Sakharova, Ekaterina A, Anisimova, Aleksandra S, Dmitriev, Sergey E, Gladyshev, Vadim N, Kulakovskiy, Ivan V

“…High-throughput sequencing often provides a foundation for experimental analyses in the life sciences. For many such methods, an intermediate layer of…”
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Human Tissues Exhibit Diverse Composition of Translation Machinery by Anisimova, Aleksandra S, Kolyupanova, Natalia M, Makarova, Nadezhda E, Egorov, Artyom A, Kulakovskiy, Ivan V, Dmitriev, Sergey E

“…While protein synthesis is vital for the majority of cell types of the human body, diversely differentiated cells require specific translation regulation. This…”
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A standard knockout procedure alters expression of adjacent loci at the translational level by Egorov, Artyom A, Alexandrov, Alexander I, Urakov, Valery N, Makeeva, Desislava S, Edakin, Roman O, Kushchenko, Artem S, Gladyshev, Vadim N, Kulakovskiy, Ivan V, Dmitriev, Sergey E

“…Abstract The Saccharomyces cerevisiae gene deletion collection is widely used for functional gene annotation and genetic interaction analyses. However, the…”
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Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2 by Dmitriev, Sergey E, Terenin, Ilya M, Shatsky, Ivan N, Andreev, Dmitry E

“…Viruses have found mechanisms to translate their RNAs in the face of antiviral responses. Data now indicate that the hepatitis C virus internal ribosome entry…”
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Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1 by Lomakin, Ivan B., Stolboushkina, Elena A., Vaidya, Anand T., Zhao, Chenguang, Garber, Maria B., Dmitriev, Sergey E., Steitz, Thomas A.

“…The repertoire of the density-regulated protein (DENR) and the malignant T cell-amplified sequence 1 (MCT-1/MCTS1) oncoprotein was recently expanded to include…”
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GTP-independent tRNA Delivery to the Ribosomal P-site by a Novel Eukaryotic Translation Factor by Dmitriev, Sergey E., Terenin, Ilya M., Andreev, Dmitri E., Ivanov, Pavel A., Dunaevsky, Jacov E., Merrick, William C., Shatsky, Ivan N.

“…During translation, aminoacyl-tRNAs are delivered to the ribosome by specialized GTPases called translation factors. Here, we report the tRNA binding to the…”
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Enteroviruses Manipulate the Unfolded Protein Response through Multifaceted Deregulation of the Ire1-Xbp1 Pathway by Shishova, Anna, Dyugay, Ilya, Fominykh, Ksenia, Baryshnikova, Victoria, Dereventsova, Alena, Turchenko, Yuriy, Slavokhotova, Anna A, Ivin, Yury, Dmitriev, Sergey E, Gmyl, Anatoly

“…Many viruses are known to trigger endoplasmic reticulum (ER) stress in host cells, which in turn can develop a protective unfolded protein response (UPR)…”
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Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH by Suntsova, Maria, Gogvadze, Elena V., Salozhin, Sergey, Gaifullin, Nurshat, Eroshkin, Fedor, Dmitriev, Sergey E., Martynova, Natalia, Kulikov, Kirill, Malakhova, Galina, Tukhbatova, Gulnur, Bolshakov, Alexey P., Ghilarov, Dmitry, Garazha, Andrew, Aliper, Alexander, Cantor, Charles R., Solokhine, Yuri, Roumiantsev, Sergey, Balaban, Pavel, Zhavoronkov, Alex, Buzdin, Anton

“…Using a systematic, whole-genome analysis of enhancer activity of human-specific endogenous retroviral inserts (hsERVs), we identified an element, hsERV PRODH,…”
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Single-domain antibody delivery using an mRNA platform protects against lethal doses of botulinum neurotoxin A by Panova, Eugenia A, Kleymenov, Denis A, Shcheblyakov, Dmitry V, Bykonia, Evgeniia N, Mazunina, Elena P, Dzharullaeva, Alina S, Zolotar, Anastasia N, Derkaev, Artem A, Esmagambetov, Ilias B, Sorokin, Ivan I, Usachev, Evgeny V, Noskov, Anatoly N, Ivanov, Igor A, Zatsepin, Timofei S, Dmitriev, Sergey E, Gushchin, Vladimir A, Naroditsky, Boris S, Logunov, Denis Y, Gintsburg, Alexander L

“…Single-domain antibodies (sdAbs, VHHs, or nanobodies) are a promising tool for the treatment of both infectious and somatic diseases. Their small size greatly…”
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Pros and cons of pDNA and mRNA transfection to study mRNA translation in mammalian cells by Andreev, Dmitry E., Terenin, Ilya M., Dmitriev, Sergey E., Shatsky, Ivan N.

“…Protein synthesis in eukaryotes is subject to stringent control. The misregulation of translation of certain mRNAs is often a hallmark of many diseases,…”
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A novel uORF-based regulatory mechanism controls translation of the human MDM2 and eIF2D mRNAs during stress by Akulich, Kseniya A., Sinitcyn, Pavel G., Makeeva, Desislava S., Andreev, Dmitry E., Terenin, Ilya M., Anisimova, Aleksandra S., Shatsky, Ivan N., Dmitriev, Sergey E.

“…Short upstream open reading frames (uORFs) are the most prevalent cis-acting regulatory elements in the mammalian transcriptome which can orchestrate mRNA…”
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Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome by Prokhorova, Irina V., Akulich, Kseniya A., Makeeva, Desislava S., Osterman, Ilya A., Skvortsov, Dmitry A., Sergiev, Petr V., Dontsova, Olga A., Yusupova, Gulnara, Yusupov, Marat M., Dmitriev, Sergey E.

“…Amicoumacin A is an antibiotic that was recently shown to target bacterial ribosomes. It affects translocation and provides an additional contact interface…”
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Trivalent mRNA vaccine-candidate against seasonal flu with cross-specific humoral immune response by Mazunina, Elena P, Gushchin, Vladimir A, Kleymenov, Denis A, Siniavin, Andrei E, Burtseva, Elena I, Shmarov, Maksim M, Mukasheva, Evgenya A, Bykonia, Evgeniia N, Kozlova, Sofia R, Evgrafova, Elina A, Zolotar, Anastasia N, Shidlovskaya, Elena V, Kirillova, Elena S, Krepkaia, Anastasiya S, Usachev, Evgeny V, Kuznetsova, Nadezhda A, Ivanov, Igor A, Dmitriev, Sergey E, Ivanov, Roman A, Logunov, Denis Y, Gintsburg, Alexander L

“…Seasonal influenza remains a serious global health problem, leading to high mortality rates among the elderly and individuals with comorbidities. Vaccination…”
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Unidirectional constant rate motion of the ribosomal scanning particle during eukaryotic translation initiation by Vassilenko, Konstantin S., Alekhina, Olga M., Dmitriev, Sergey E., Shatsky, Ivan N., Spirin, Alexander S.

“…According to the model of translation initiation in eukaryotes, the 40S ribosomal subunit binds to capped 5′-end of mRNA and subsequently migrates along 5′-UTR…”
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Cap- and IRES-independent scanning mechanism of translation initiation as an alternative to the concept of cellular IRESs by Shatsky, Ivan N, Dmitriev, Sergey E, Terenin, Ilya M, Andreev, D E

“…During the last decade the concept of cellular IRES-elements has become predominant to explain the continued expression of specific proteins in eukaryotic…”
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In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan by Ribeiro, Rui, Macedo, Joana C, Costa, Madalena, Ustiyan, Vladimir, Shindyapina, Anastasia V, Tyshkovskiy, Alexander, Gomes, Rita N, Castro, José Pedro, Kalin, Tanya V, Vasques-Nóvoa, Francisco, Nascimento, Diana S, Dmitriev, Sergey E, Gladyshev, Vadim N, Kalinichenko, Vladimir V, Logarinho, Elsa

“…The FOXM1 transcription factor exhibits pleiotropic C-terminal transcriptional and N-terminal non-transcriptional functions in various biological processes…”
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