Search Results - "Dlugosz, Andrzej A"

Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma by Sharpe, Hayley J., Pau, Gregoire, Dijkgraaf, Gerrit J., Basset-Seguin, Nicole, Modrusan, Zora, Januario, Thomas, Tsui, Vickie, Durham, Alison B., Dlugosz, Andrzej A., Haverty, Peter M., Bourgon, Richard, Tang, Jean Y., Sarin, Kavita Y., Dirix, Luc, Fisher, David C., Rudin, Charles M., Sofen, Howard, Migden, Michael R., Yauch, Robert L., de Sauvage, Frederic J.

“…Smoothened (SMO) inhibitors are under clinical investigation for the treatment of several cancers. Vismodegib is approved for the treatment of locally advanced…”
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Basal Cell Carcinoma Preferentially Arises from Stem Cells within Hair Follicle and Mechanosensory Niches by Peterson, Shelby C., Eberl, Markus, Vagnozzi, Alicia N., Belkadi, Abdelmadjid, Veniaminova, Natalia A., Verhaegen, Monique E., Bichakjian, Christopher K., Ward, Nicole L., Dlugosz, Andrzej A., Wong, Sunny Y.

“…Basal cell carcinoma (BCC) is characterized by frequent loss of PTCH1, leading to constitutive activation of the Hedgehog pathway. Although the requirement for…”
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Obesity accelerates hair thinning by stem cell-centric converging mechanisms by Morinaga, Hironobu, Mohri, Yasuaki, Grachtchouk, Marina, Asakawa, Kyosuke, Matsumura, Hiroyuki, Oshima, Motohiko, Takayama, Naoya, Kato, Tomoki, Nishimori, Yuriko, Sorimachi, Yuriko, Takubo, Keiyo, Suganami, Takayoshi, Iwama, Atsushi, Iwakura, Yoichiro, Dlugosz, Andrzej A., Nishimura, Emi K.

“…Obesity is a worldwide epidemic that predisposes individuals to many age-associated diseases, but its exact effects on organ dysfunction are largely unknown 1…”
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Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1-Mediated Secretion of Extracellular Vesicles by Grunberg, Nil, Pevsner-Fischer, Meirav, Goshen-Lago, Tal, Diment, Judith, Stein, Yaniv, Lavon, Hagar, Mayer, Shimrit, Levi-Galibov, Oshrat, Friedman, Gil, Ofir-Birin, Yifat, Syu, Li-Jyun, Migliore, Cristina, Shimoni, Eyal, Stemmer, Salomon M, Brenner, Baruch, Dlugosz, Andrzej A, Lyden, David, Regev-Rudzki, Neta, Ben-Aharon, Irit, Scherz-Shouval, Ruth

“…Gastric cancer is the third most lethal cancer worldwide, and evaluation of the genomic status of gastric cancer cells has not translated into effective…”
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Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin by Coulombe, Pierre A, DePianto, Daryle, Kerns, Michelle L, Dlugosz, Andrzej A

“…Basaloid skin tumors, including basal cell carcinoma (BCC) and basaloid follicular hamartoma, are associated with aberrant Hedgehog (Hh) signaling and, in the…”
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Dual and opposing roles of primary cilia in medulloblastoma development by Alvarez-Buylla, Arturo, Han, Young-Goo, Kim, Hong Joo, Dlugosz, Andrzej A, Ellison, David W, Gilbertson, Richard J

“…Recent work has shown that primary cilia are essential for Hedgehog (Hh) signaling during mammalian development. It is also known that aberrant Hh signaling…”
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Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis by Reiter, Jeremy F, Wong, Sunny Y, Seol, Allen D, So, Po-Lin, Ermilov, Alexandre N, Bichakjian, Christopher K, Epstein, Ervin H, Dlugosz, Andrzej A

“…Primary cilia are present on most mammalian cells and are implicated in transducing Hedgehog (Hh) signals during development; however, the prevalence of cilia…”
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Hedgehog/Ras interactions regulate early stages of pancreatic cancer by Pasca di Magliano, Marina, Sekine, Shigeki, Ermilov, Alexandre, Ferris, Jenny, Dlugosz, Andrzej A, Hebrok, Matthias

“…Pancreatic ductal adenocarcinoma (PDA) constitutes a lethal disease that affects >30,000 people annually in the United States. Deregulation of Hedgehog…”
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Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling by Ermilov, Alexandre N, Kumari, Archana, Li, Libo, Joiner, Ariell M, Grachtchouk, Marina A, Allen, Benjamin L, Dlugosz, Andrzej A, Mistretta, Charlotte M

“…For homeostasis, lingual taste papilla organs require regulation of epithelial cell survival and renewal, with sustained innervation and stromal interactions…”
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Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem Cells in the Skin by Veniaminova, Natalia A., Grachtchouk, Marina, Doane, Owen J., Peterson, Jamie K., Quigley, David A., Lull, Madison V., Pyrozhenko, Daryna V., Nair, Raji R., Patrick, Matthew T., Balmain, Allan, Dlugosz, Andrzej A., Tsoi, Lam C., Wong, Sunny Y.

“…Oil-secreting sebaceous glands (SGs) are critical for proper skin function; however, it remains unclear how different factors act together to modulate SG stem…”
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Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury by Veniaminova, Natalia A., Jia, Yunlong Y., Hartigan, Adrien M., Huyge, Thomas J., Tsai, Shih-Ying, Grachtchouk, Marina, Nakagawa, Seitaro, Dlugosz, Andrzej A., Atwood, Scott X., Wong, Sunny Y.

“…Sebaceous glands (SGs) release oils that protect our skin, but how these glands respond to injury has not been previously examined. Here, we report that SGs…”
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Next generation sequencing of Cytokeratin 20-negative Merkel cell carcinoma reveals ultraviolet-signature mutations and recurrent TP53 and RB1 inactivation by Harms, Paul W, Collie, Angela M B, Hovelson, Daniel H, Cani, Andi K, Verhaegen, Monique E, Patel, Rajiv M, Fullen, Douglas R, Omata, Kei, Dlugosz, Andrzej A, Tomlins, Scott A, Billings, Steven D

“…Merkel cell carcinoma is a rare but highly aggressive cutaneous neuroendocrine carcinoma. Cytokeratin 20 (CK20) is expressed in ~95% of Merkel cell carcinomas…”
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Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations by Grachtchouk, Marina, Pero, Joanna, Yang, Steven H, Ermilov, Alexandre N, Michael, L Evan, Wang, Aiqin, Wilbert, Dawn, Patel, Rajiv M, Ferris, Jennifer, Diener, James, Allen, Mary, Lim, Seokchun, Syu, Li-Jyun, Verhaegen, Monique, Dlugosz, Andrzej A

“…Uncontrolled Hedgehog (Hh) signaling leads to the development of basal cell carcinoma (BCC), the most common human cancer, but the cell of origin for BCC is…”
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Corrigendum to “Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma” [Neoplasia, Volume 21, Issue 3 (2019) 322–330] by Choi, Jae Eun, Verhaegen, Monique E., Yazdani, Sahr, Malik, Rohit, Harms, Paul W., Mangelberger, Doris, Tien, Jean, Cao, Xuhong, Wang, Yuping, Cieślik, Marcin, Gurkan, Jonathan, Yazdani, Mishaal, Jing, Xiaojun, Juckette, Kristin, Su, Fengyun, Wang, Rui, Zhou, Bing, Apel, Ingrid J., Wang, Shaomeng, Dlugosz, Andrzej A., Chinnaiyan, Arul M.

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Direct cellular reprogramming enables development of viral T antigen-driven Merkel cell carcinoma in mice by Verhaegen, Monique E, Harms, Paul W, Van Goor, Julia J, Arche, Jacob, Patrick, Matthew T, Wilbert, Dawn, Zabawa, Haley, Grachtchouk, Marina, Liu, Chia-Jen, Hu, Kevin, Kelly, Michael C, Chen, Ping, Saunders, Thomas L, Weidinger, Stephan, Syu, Li-Jyun, Runge, John S, Gudjonsson, Johann E, Wong, Sunny Y, Brownell, Isaac, Cieslik, Marcin, Udager, Aaron M, Chinnaiyan, Arul M, Tsoi, Lam C, Dlugosz, Andrzej A

“…Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer that frequently carries an integrated Merkel cell polyomavirus (MCPyV) genome and…”
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Corrigendum to “Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma” [Neoplasia, Volume 21, Issue 3 (2019) 322–330] by Choi, Jae Eun, Verhaegen, Monique E., Yazdani, Sahr, Malik, Rohit, Harms, Paul W., Mangelberger, Doris, Tien, Jean, Cao, Xuhong, Wang, Yuping, Cieślik, Marcin, Gurkan, Jonathan, Yazdani, Mishaal, Jing, Xiaojun, Juckette, Kristin, Su, Fengyun, Wang, Rui, Zhou, Bing, Apel, Ingrid J., Wang, Shaomeng, Dlugosz, Andrzej A., Chinnaiyan, Arul M.

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Reciprocal interplay between thyroid hormone and microRNA-21 regulates hedgehog pathway-driven skin tumorigenesis by Di Girolamo, Daniela, Ambrosio, Raffaele, De Stefano, Maria A, Mancino, Giuseppina, Porcelli, Tommaso, Luongo, Cristina, Di Cicco, Emery, Scalia, Giulia, Vecchio, Luigi Del, Colao, Annamaria, Dlugosz, Andrzej A, Missero, Caterina, Salvatore, Domenico, Dentice, Monica

“…The thyroid hormone-inactivating (TH-inactivating) enzyme type 3 iodothyronine deiodinase (D3) is an oncofetal protein that is rarely expressed in adult life…”
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Multiple Shh signaling centers participate in fungiform papilla and taste bud formation and maintenance by Liu, Hong Xiang, Ermilov, Alexandre, Grachtchouk, Marina, Li, Libo, Gumucio, Deborah L., Dlugosz, Andrzej A., Mistretta, Charalotte M.

“…The adult fungiform taste papilla is a complex of specialized cell types residing in the stratified squamous tongue epithelium. This unique sensory organ…”
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Distinct Gene Expression Profiles of Viral- and Nonviral-Associated Merkel Cell Carcinoma Revealed by Transcriptome Analysis by Harms, Paul W., Patel, Rajiv M., Verhaegen, Monique E., Giordano, Thomas J., Nash, Kevin T., Johnson, Craig N., Daignault, Stephanie, Thomas, Dafydd G., Gudjonsson, Johann E., Elder, James T., Dlugosz, Andrzej A., Johnson, Timothy M., Fullen, Douglas R., Bichakjian, Christopher K.

“…Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine tumor with high mortality rates. Merkel cell polyomavirus (MCPyV), identified in the…”
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Paracrine Hedgehog Signaling in Stomach and Intestine: New Roles for Hedgehog in Gastrointestinal Patterning by Kolterud, Åsa, Grosse, Ann S, Zacharias, William J, Walton, Katherine D, Kretovich, Katherine E, Madison, Blair B, Waghray, Meghna, Ferris, Jennifer E, Hu, Chunbo, Merchant, Juanita L, Dlugosz, Andrzej A, Kottmann, Andreas H, Gumucio, Deborah L

“…Background & Aims Hedgehog signaling is critical in gastrointestinal patterning. Mice deficient in Hedgehog signaling exhibit abnormalities that mirror…”
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