Search Results - "Dlugosz, A."

Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma by Sharpe, Hayley J., Pau, Gregoire, Dijkgraaf, Gerrit J., Basset-Seguin, Nicole, Modrusan, Zora, Januario, Thomas, Tsui, Vickie, Durham, Alison B., Dlugosz, Andrzej A., Haverty, Peter M., Bourgon, Richard, Tang, Jean Y., Sarin, Kavita Y., Dirix, Luc, Fisher, David C., Rudin, Charles M., Sofen, Howard, Migden, Michael R., Yauch, Robert L., de Sauvage, Frederic J.

“…Smoothened (SMO) inhibitors are under clinical investigation for the treatment of several cancers. Vismodegib is approved for the treatment of locally advanced…”
Get full text

Obesity accelerates hair thinning by stem cell-centric converging mechanisms by Morinaga, Hironobu, Mohri, Yasuaki, Grachtchouk, Marina, Asakawa, Kyosuke, Matsumura, Hiroyuki, Oshima, Motohiko, Takayama, Naoya, Kato, Tomoki, Nishimori, Yuriko, Sorimachi, Yuriko, Takubo, Keiyo, Suganami, Takayoshi, Iwama, Atsushi, Iwakura, Yoichiro, Dlugosz, Andrzej A., Nishimura, Emi K.

“…Obesity is a worldwide epidemic that predisposes individuals to many age-associated diseases, but its exact effects on organ dysfunction are largely unknown 1…”
Get full text

Basal Cell Carcinoma Preferentially Arises from Stem Cells within Hair Follicle and Mechanosensory Niches by Peterson, Shelby C., Eberl, Markus, Vagnozzi, Alicia N., Belkadi, Abdelmadjid, Veniaminova, Natalia A., Verhaegen, Monique E., Bichakjian, Christopher K., Ward, Nicole L., Dlugosz, Andrzej A., Wong, Sunny Y.

“…Basal cell carcinoma (BCC) is characterized by frequent loss of PTCH1, leading to constitutive activation of the Hedgehog pathway. Although the requirement for…”
Get full text

Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1-Mediated Secretion of Extracellular Vesicles by Grunberg, Nil, Pevsner-Fischer, Meirav, Goshen-Lago, Tal, Diment, Judith, Stein, Yaniv, Lavon, Hagar, Mayer, Shimrit, Levi-Galibov, Oshrat, Friedman, Gil, Ofir-Birin, Yifat, Syu, Li-Jyun, Migliore, Cristina, Shimoni, Eyal, Stemmer, Salomon M, Brenner, Baruch, Dlugosz, Andrzej A, Lyden, David, Regev-Rudzki, Neta, Ben-Aharon, Irit, Scherz-Shouval, Ruth

“…Gastric cancer is the third most lethal cancer worldwide, and evaluation of the genomic status of gastric cancer cells has not translated into effective…”
Get full text

Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin by Coulombe, Pierre A, DePianto, Daryle, Kerns, Michelle L, Dlugosz, Andrzej A

“…Basaloid skin tumors, including basal cell carcinoma (BCC) and basaloid follicular hamartoma, are associated with aberrant Hedgehog (Hh) signaling and, in the…”
Get full text

Dual and opposing roles of primary cilia in medulloblastoma development by Alvarez-Buylla, Arturo, Han, Young-Goo, Kim, Hong Joo, Dlugosz, Andrzej A, Ellison, David W, Gilbertson, Richard J

“…Recent work has shown that primary cilia are essential for Hedgehog (Hh) signaling during mammalian development. It is also known that aberrant Hh signaling…”
Get full text

Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis by Reiter, Jeremy F, Wong, Sunny Y, Seol, Allen D, So, Po-Lin, Ermilov, Alexandre N, Bichakjian, Christopher K, Epstein, Ervin H, Dlugosz, Andrzej A

“…Primary cilia are present on most mammalian cells and are implicated in transducing Hedgehog (Hh) signals during development; however, the prevalence of cilia…”
Get full text

Increased Prevalence of Rare Sucrase-isomaltase Pathogenic Variants in Irritable Bowel Syndrome Patients by Garcia-Etxebarria, Koldo, Zheng, Tenghao, Bonfiglio, Ferdinando, Bujanda, Luis, Dlugosz, Aldona, Lindberg, Greger, Schmidt, Peter T., Karling, Pontus, Ohlsson, Bodil, Simren, Magnus, Walter, Susanna, Nardone, Gerardo, Cuomo, Rosario, Usai-Satta, Paolo, Galeazzi, Francesca, Neri, Matteo, Portincasa, Piero, Bellini, Massimo, Barbara, Giovanni, Jonkers, Daisy, Eswaran, Shanti, Chey, William D., Kashyap, Purna, Chang, Lin, Mayer, Emeran A., Wouters, Mira M., Boeckxstaens, Guy, Camilleri, Michael, Franke, Andre, D’Amato, Mauro

“…Patients with irritable bowel syndrome (IBS) often associate their symptoms to certain foods. In congenital sucrase-isomaltase deficiency (CSID), recessive…”
Get full text

Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling by Ermilov, Alexandre N, Kumari, Archana, Li, Libo, Joiner, Ariell M, Grachtchouk, Marina A, Allen, Benjamin L, Dlugosz, Andrzej A, Mistretta, Charlotte M

“…For homeostasis, lingual taste papilla organs require regulation of epithelial cell survival and renewal, with sustained innervation and stromal interactions…”
Get full text

Preliminary Evaluation of the Diagnostic Usefulness of Uroplakin 2 with an Assessment of the Antioxidant Potential of Patients with Bladder Cancer by Dembowski, J., Małkiewicz, B., Długosz, A., Szymańska, B., Matuszewski, M., Piwowar, Agnieszka

“…Background. Urothelial carcinoma is the most common type of bladder cancer (BC). It makes up more than 90% of all bladder cancers. Uroplakins are…”
Get full text

Uroplakin IIIa Is a Marker in Bladder Cancer but Seems Not to Reflect Chemical Carcinogenesis by Zdrojowy, Romuald, Dembowski, J., Matuszewski, M., Szymańska, B., Długosz, A.

“…Background. Uroplakins are glycoproteins investigated as potential markers of urothelial carcinoma. However, their role in chemical carcinogenesis is…”
Get full text

Hedgehog/Ras interactions regulate early stages of pancreatic cancer by Pasca di Magliano, Marina, Sekine, Shigeki, Ermilov, Alexandre, Ferris, Jenny, Dlugosz, Andrzej A, Hebrok, Matthias

“…Pancreatic ductal adenocarcinoma (PDA) constitutes a lethal disease that affects >30,000 people annually in the United States. Deregulation of Hedgehog…”
Get full text

Multiple Shh signaling centers participate in fungiform papilla and taste bud formation and maintenance by Liu, Hong Xiang, Ermilov, Alexandre, Grachtchouk, Marina, Li, Libo, Gumucio, Deborah L., Dlugosz, Andrzej A., Mistretta, Charalotte M.

“…The adult fungiform taste papilla is a complex of specialized cell types residing in the stratified squamous tongue epithelium. This unique sensory organ…”
Get full text

Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem Cells in the Skin by Veniaminova, Natalia A., Grachtchouk, Marina, Doane, Owen J., Peterson, Jamie K., Quigley, David A., Lull, Madison V., Pyrozhenko, Daryna V., Nair, Raji R., Patrick, Matthew T., Balmain, Allan, Dlugosz, Andrzej A., Tsoi, Lam C., Wong, Sunny Y.

“…Oil-secreting sebaceous glands (SGs) are critical for proper skin function; however, it remains unclear how different factors act together to modulate SG stem…”
Get full text

Increased serum levels of lipopolysaccharide and antiflagellin antibodies in patients with diarrhea‐predominant irritable bowel syndrome by Dlugosz, A., Nowak, P., D'Amato, M., Mohammadian Kermani, G., Nyström, J., Abdurahman, S., Lindberg, G.

“…Background Innate immune responses to conserved microbial products such as lipopolysaccharide (LPS) and flagellin are likely important in microbial–host…”
Get full text

Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury by Veniaminova, Natalia A., Jia, Yunlong Y., Hartigan, Adrien M., Huyge, Thomas J., Tsai, Shih-Ying, Grachtchouk, Marina, Nakagawa, Seitaro, Dlugosz, Andrzej A., Atwood, Scott X., Wong, Sunny Y.

“…Sebaceous glands (SGs) release oils that protect our skin, but how these glands respond to injury has not been previously examined. Here, we report that SGs…”
Get full text

Next generation sequencing of Cytokeratin 20-negative Merkel cell carcinoma reveals ultraviolet-signature mutations and recurrent TP53 and RB1 inactivation by Harms, Paul W, Collie, Angela M B, Hovelson, Daniel H, Cani, Andi K, Verhaegen, Monique E, Patel, Rajiv M, Fullen, Douglas R, Omata, Kei, Dlugosz, Andrzej A, Tomlins, Scott A, Billings, Steven D

“…Merkel cell carcinoma is a rare but highly aggressive cutaneous neuroendocrine carcinoma. Cytokeratin 20 (CK20) is expressed in ~95% of Merkel cell carcinomas…”
Get full text

Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations by Grachtchouk, Marina, Pero, Joanna, Yang, Steven H, Ermilov, Alexandre N, Michael, L Evan, Wang, Aiqin, Wilbert, Dawn, Patel, Rajiv M, Ferris, Jennifer, Diener, James, Allen, Mary, Lim, Seokchun, Syu, Li-Jyun, Verhaegen, Monique, Dlugosz, Andrzej A

“…Uncontrolled Hedgehog (Hh) signaling leads to the development of basal cell carcinoma (BCC), the most common human cancer, but the cell of origin for BCC is…”
Get full text

Corrigendum to “Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma” [Neoplasia, Volume 21, Issue 3 (2019) 322–330] by Choi, Jae Eun, Verhaegen, Monique E., Yazdani, Sahr, Malik, Rohit, Harms, Paul W., Mangelberger, Doris, Tien, Jean, Cao, Xuhong, Wang, Yuping, Cieślik, Marcin, Gurkan, Jonathan, Yazdani, Mishaal, Jing, Xiaojun, Juckette, Kristin, Su, Fengyun, Wang, Rui, Zhou, Bing, Apel, Ingrid J., Wang, Shaomeng, Dlugosz, Andrzej A., Chinnaiyan, Arul M.

Get full text

Direct cellular reprogramming enables development of viral T antigen-driven Merkel cell carcinoma in mice by Verhaegen, Monique E, Harms, Paul W, Van Goor, Julia J, Arche, Jacob, Patrick, Matthew T, Wilbert, Dawn, Zabawa, Haley, Grachtchouk, Marina, Liu, Chia-Jen, Hu, Kevin, Kelly, Michael C, Chen, Ping, Saunders, Thomas L, Weidinger, Stephan, Syu, Li-Jyun, Runge, John S, Gudjonsson, Johann E, Wong, Sunny Y, Brownell, Isaac, Cieslik, Marcin, Udager, Aaron M, Chinnaiyan, Arul M, Tsoi, Lam C, Dlugosz, Andrzej A

“…Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer that frequently carries an integrated Merkel cell polyomavirus (MCPyV) genome and…”
Get full text