Search Results - "Dlamini, Samkeliso"

Tumor suppressor p53 promotes ferroptosis in oxidative stress conditions independent of modulation of ferroptosis by p21, CDKs, RB, and E2F by Kuganesan, Nishanth, Dlamini, Samkeliso, Tillekeratne, L. M. Viranga, Taylor, William R.

“…p53 is a well-established critical cell cycle regulator. By inducing transcription of the gene encoding p21, p53 inhibits cyclin-dependent kinase…”
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Small-Molecule Ferroptotic Agents with Potential to Selectively Target Cancer Stem Cells by Taylor, William R., Fedorka, Sara R., Gad, Ibtissam, Shah, Ronit, Alqahtani, Hanan D., Koranne, Radhika, Kuganesan, Nishanth, Dlamini, Samkeliso, Rogers, Tim, Al-Hamashi, Ayad, Kholodovych, Veronika, Barudi, Yusuf, Junk, Damian, Rashid, Maisha S., Jackson, Mark W., Tillekeratne, L. M. Viranga

“…Effective management of advanced cancer requires systemic treatment including small molecules that target unique features of aggressive tumor cells. At the…”
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Abstract 2578: Tumor suppressor p53 promotes ferroptosis in oxidative stress conditions independent of modulation of ferroptosis by p21, CDKs, RB, and E2F by Kuganesan, Nishanth, Dlamini, Samkeliso, Tillekeratne, Viranga, Taylor, William

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1485: Development of GLUT-1 targeted boron carriers for Boron Neutron Capture Therapy (BNCT) by Martin, Tioga J., Raitano, Art, Dlamini, Samkeliso, Zhang, Chunying, Capo, Linnette, Ikeura, Maki, Morrison, Karen, Malinao, Maria Christina, Quintana, Jason, Morrison, Kendall, Torgov, Michael

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Identification and initial characterization of a potent inhibitor of ferroptosis by Kuganesan, Nishanth, Dlamini, Samkeliso, McDaniel, Jade, Tillekeratne, Viranga L. M., Taylor, William R.

“…Ferroptosis is a form of iron‐dependent cell death characterized by elevated lipid peroxides and reactive oxygen species (ROS). Glutathione (GSH) plays an…”
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Boronotyrosine, a Borylated Amino Acid Mimetic with Enhanced Solubility, Tumor Boron Delivery, and Retention for the Re-emerging Boron Neutron Capture Therapy Field by Raitano, Arthur, Martin, Tioga, Zhang, Chunying, Malinao, Maria-Christina, Capo, Linnette, Ikeura, Maki, Carroll, Rebecca, Quintana, Jason C., Dlamini, Samkeliso, Kulenovic, Leila, Jahanshir, Eva, Kang, Sohye, Morrison, Karen, Torgov, Michael, Morrison, Kendall

“…Boron neutron capture therapy (BNCT) is a re-emerging binary cellular level cancer intervention that occurs through the interaction of a cancer-specific…”
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CETZOLE Analogs as Potent Ferroptosis Inducers and Their Target Identification Using Covalent/Affinity Probes by Dlamini, Samkeliso, Mohajeri, Shahrzad, Kuganesan, Nishanth, Sindi, Shaimaa H., Karaj, Endri, Rathnayake, Dewmi S., McDaniel, Jade, Taylor, William R., Tillekeratne, L. M. Viranga

“…Ferroptosis is a recently discovered cell death mechanism triggered by iron-dependent elevation of reactive oxygen species leading to lipid membrane…”
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Bioactive constituents isolated from the Sri Lankan endemic plant Artocarpus nobilis and their potential to use in novel cosmeceuticals by Liyanaararchchi, Gavini Dilkhushi, Perera, Anton Sameera, Samarasekera, Jayanetti Koralalage Ramani Radhika, Mahanama, Kariyawasam Ranaweerage Ranjith, Hemalal, Kirihettiliyanage Don Patrick, Dlamini, Samkeliso, Perera, Hettiarachchige Dona Sachindra Melshandi, Alhadidi, Qasim, Shah, Zahoor A., Tillekeratne, L.M. Viranga

“…Two novel compounds, dicarbonyl ester (2) and artolankanin A (3) were isolated from the sequential ethyl acetate and ethanol extracts of stem bark of A…”
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Mutant p53 reactivators protect breast cancer cells from ferroptosis by Rathnayake, Dewmi Sandaru, Dlamini, Samkeliso, Elkalawozgy, Kadry, Tillekeratne, L. M. Viranga, Taylor, William R.

“…Ferroptosis is a novel nonapoptotic form of cell death characterized by iron‐dependent reactive oxygen species‐mediated lipid peroxidation. In several…”
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Synthesis and Biological Evaluation of Anti-Cancer Agents and Identification of Their Molecular Targets by Dlamini, Samkeliso M

“…Ferroptosis is a recently discovered non-apoptotic cell death mechanism with potential to expand the cancer drug armamentarium. Ferroptotic agents induce…”
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Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics by Karaj, Endri, Dlamini, Samkeliso, Koranne, Radhika, Sindi, Shaimaa H., Perera, Lalith, Taylor, William R., Viranga Tillekeratne, L.M.

“…[Display omitted] •Structure-activity relationship of imidazole chalcone mimics.•Cytotoxic with IC50 values in the upper nanomolar to low micromolar…”
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Synthesis and Development of a Novel First-in-Class Cofilin Inhibitor for Neuroinflammation in Hemorrhagic Brain Injury by Alaqel, Saleh I, Dlamini, Samkeliso, Almarghalani, Daniyah A, Shettigar, Arjun, Alhadidi, Qasim, Kodithuwakku, Sinali H, Stary, Creed, Tillekeratne, L. M. Viranga, Shah, Zahoor A

“…Intracerebral hemorrhage (ICH) is devastating among stroke types with high mortality. To date, not a single therapeutic intervention has been successful…”
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A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics by Al-Hamashi, Ayad A., Koranne, Radhika, Dlamini, Samkeliso, Alqahtani, Abdulateef, Karaj, Endri, Rashid, Maisha S., Knoff, Joseph R., Dunworth, Matthew, Pflum, Mary Kay H., Casero, Robert A., Perera, Lalith, Taylor, William R., Tillekeratne, L.M. Viranga

“…[Display omitted] •Synthesis of chalcone mimics containing an imidazole-based metal-binding group intended for HDAC inhibition.•Compounds showed cytotoxicity…”
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In Search of Selectivity: Design, Synthesis, and Biological Evaluation of New Classes of HDAC Inhibitors by L. M. Viranga Tillekeratne, Ayad Ayad Al-Hamashi, Samkeliso Dlamini, William Taylor, Radhika Koranne, Mary Kay Pflum, Ahmed T. Negmeldin, Joseph Knoff

“…Epigenetic regulation of gene expression without changing DNA sequences is a promising strategy in developing therapeutic agents for human diseases, especially…”
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Synthesis and Biological Evaluation of HDAC Inhibitors with 1-(1H-imidazol-2-yl)ethan-1-one Moiety as the Metal-Binding Group by Dlamini, Samkeliso M

“…Cancer is the second leading cause of death in the United States of America and the entire world and the disease burden is exacerbated due to resistance to…”
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