Butyrylcholinesterase activity and mortality risk in hemodialysis patients: Comparison to hsCRP and albumin

To test the prediction power of butyrylcholinesterase (BuChE) activity for mortality risk in hemodialysis patients during 12 months follow-up, and made comparison to hsCRP and albumin. The study enrolled 62 patients, aged 31–79 years. Serum BuChE, high-sensitivity C-reactive protein (hsCRP) and albu...

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Published in:	Clinical biochemistry Vol. 42; no. 1; pp. 22 - 26
Main Authors:	Stojanov, Marina D., Jovičić, Dušanka M., Djurić, Stevan P., Konjević, Marija M., Todorović, Zoran M., Prostran, Milica Š.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 2009
Subjects:	Adult Aged Albumin Butyrylcholinesterase Butyrylcholinesterase - blood C-Reactive Protein - metabolism End-stage renal disease Female Hemodialysis High-sensitivity C-reactive protein Humans Kidney Failure, Chronic - blood Kidney Failure, Chronic - mortality Kidney Failure, Chronic - therapy Male Middle Aged Renal Dialysis Risk Factors Serum Albumin - metabolism Albumin End-stage renal disease High-sensitivity C-reactive protein Butyrylcholinesterase Hemodialysis
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Summary:	To test the prediction power of butyrylcholinesterase (BuChE) activity for mortality risk in hemodialysis patients during 12 months follow-up, and made comparison to hsCRP and albumin. The study enrolled 62 patients, aged 31–79 years. Serum BuChE, high-sensitivity C-reactive protein (hsCRP) and albumin were measured after 1, 3, 9 and 12 months of dialysis. The Kaplan–Meier survival curves were employed in mortality prediction. BuChE was positively associated with serum albumin ( r = 0.318; p = 0.012) and inversely related to hsCRP ( r = − 0.358; p = 0.004). The highest mortality was in the lowest quartile of basal albumin (< 38.4 g/L; p = 0.027), hsCRP concentrations > 8 mg/L ( p = 0.005), and BuChE activity in the lowest tercile of basal values (< 5.92 kU/L; p = 0.0041). Our results suggest that low BuChE activity may be a nonspecific risk factor for mortality in patients who are on hemodialysis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0009-9120 1873-2933
DOI:	10.1016/j.clinbiochem.2008.10.010