Risk factors for multidrug-resistant tuberculosis in the Central African Republic: A case-control study

The emergence and spread of multidrug-resistant tuberculosis (MDR-TB) presents a challenge to the "End TB by 2035" strategy. This study aimed to identify the risk factors associated with MDR-TB in patients admitted to the pneumo-physiology clinic of the National University Hospital of Bang...

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Bibliographic Details
Published in:	Journal of infection and public health Vol. 16; no. 9; pp. 1341 - 1345
Main Authors:	de Dieu Longo, Jean, Woromogo, Sylvain Honoré, Tekpa, Gaspard, Diemer, Henri Saint-Calvaire, Gando, Hervé, Djidéré, Fernand Armel, Grésenguet, Gérard
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-09-2023 Elsevier
Subjects:	Bangui Multidrug-resistant tuberculosis Risk factors Tuberculosis Multidrug-resistant tuberculosis Tuberculosis Bangui Risk factors
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Summary:	The emergence and spread of multidrug-resistant tuberculosis (MDR-TB) presents a challenge to the "End TB by 2035" strategy. This study aimed to identify the risk factors associated with MDR-TB in patients admitted to the pneumo-physiology clinic of the National University Hospital of Bangui in Central African Republic. This was a “retrospective” chart review study. Cases were represented by patients more than 18 years of age treated for MDR-TB and controls were patients with “at least rifampicin-susceptible” TB treated "with first-line anti-TB regimen" and who at the end of treatment were declared cured. The status of “cured” was exclusively applicable to non-MDR TB. Risk factors associated with MDR-TB were identified by multivariate analysis. We included 70 cases and 140 controls. The median age was 35 years, IQR (22;46 years). The main factors associated with the occurrence of MDR-TB in multivariate analysis were male gender (0 R = 3.02 [1.89–3.99], p = 0.001), residence in a peri-urban/urban area (0 R = 3.06 [2.21–4.01], p = 0.002), history of previous TB treatment (0 R= 3.99 [2.77–4.25], p < 0.001) and the presence of multidrug-resistant TB in the family (0 R=1.86 [1.27–2.45], p = 0.021). The emergence of MDR-TB can be reduced by implementing appropriate strategies, such as preventive therapy in contacts of MDR-TB patients and detecting and appropriately treating MDR-TB patients to prevent further spread of infection.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1876-0341 1876-035X
DOI:	10.1016/j.jiph.2023.06.007