Effect of flavonoids from various Mediterranean plants on enzymatic activity of intestinal carboxylesterase

Flavonol compounds of three Mediterranean plants from the Algerian Atlas used traditionally in Arab folk medicine, Arenaria serpyllifolia, Rhamnus alaternus and Thapsia garganica, were found to inhibit the enzymatic activities of both rat intestine and purified porcine liver carboxylesterase in a co...

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Bibliographic Details
Published in:	Biochimie Vol. 86; no. 12; pp. 919 - 925
Main Authors:	Stocker, P., Yousfi, M., Djerridane, O., Perrier, J., Amziani, R., El Boustani, S., Moulin, A.
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01-12-2004
Subjects:	Animals Apiaceae Arenaria Plant Carboxylesterase - antagonists & inhibitors Dose-Response Relationship, Drug Flavonoids - chemistry Flavonoids - pharmacology Intestines - drug effects Intestines - enzymology Isoenzymes - antagonists & inhibitors Kinetics Male Mediterranean Sea Plant Extracts - chemistry Plant Extracts - pharmacology Plants, Medicinal Rats Rats, Sprague-Dawley Rhamnus Structure-Activity Relationship Mediterranean Sea
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Summary:	Flavonol compounds of three Mediterranean plants from the Algerian Atlas used traditionally in Arab folk medicine, Arenaria serpyllifolia, Rhamnus alaternus and Thapsia garganica, were found to inhibit the enzymatic activities of both rat intestine and purified porcine liver carboxylesterase in a concentration-dependent manner. Results indicate that the flavonol compounds from the aerial part of these plants lead to the inactivation of the CE pI = 5.1 with K i of micromolar range. These results encourage us to perform further biological investigation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0300-9084 1638-6183
DOI:	10.1016/j.biochi.2004.09.005