Search Results - "Djebari, Souhail"
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Activation of G-protein-gated inwardly rectifying potassium (Kir3/GirK) channels rescues hippocampal functions in a mouse model of early amyloid-β pathology
Published in Scientific reports (07-11-2017)“…The hippocampus plays a critical role in learning and memory. Its correct performance relies on excitatory/inhibitory synaptic transmission balance. In early…”
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Systematic characterization of a non-transgenic Aβ 1–42 amyloidosis model: synaptic plasticity and memory deficits in female and male mice
Published in Biology of sex differences (01-12-2023)“…Abstract Background The amyloid-β (Aβ) cascade is one of the most studied theories linked to AD. In multiple models, Aβ accumulation and dyshomeostasis have…”
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SYSTEMATIC CHARACTERIZATION OF A NON-TRANSGENIC AΒ1–42 AMYLOIDOSIS MODEL: SYNAPTIC PLASTICITY AND MEMORY DEFICITS IN FEMALE AND MALE MICE
Published in IBRO neuroscience reports (01-10-2023)Get full text
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Publisher Correction: Activation of G-protein-gated inwardly rectifying potassium (Kir3/GirK) channels rescues hippocampal functions in a mouse model of early amyloid-β pathology
Published in Scientific reports (29-01-2020)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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NEW INSIGHTS INTO CPT1C FUNCTIONS RELATED TO LEARNING AND MEMORY: FROM SYNAPSES TO BEHAVIOR
Published in IBRO neuroscience reports (01-10-2023)Get full text
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Impairments of Synaptic Plasticity Induction Threshold and Network Oscillatory Activity in the Hippocampus Underlie Memory Deficits in a Non-Transgenic Mouse Model of Amyloidosis
Published in Biology (Basel, Switzerland) (01-07-2020)“…In early Alzheimer disease (AD) models synaptic failures and upstreaming aberrant patterns of network synchronous activity result in hippocampal-dependent…”
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G-Protein-Gated Inwardly Rectifying Potassium (Kir3/GIRK) Channels Govern Synaptic Plasticity That Supports Hippocampal-Dependent Cognitive Functions in Male Mice
Published in The Journal of neuroscience (18-08-2021)“…The G-protein-gated inwardly rectifying potassium (Kir3/GIRK) channel is the effector of many G-protein-coupled receptors (GPCRs). Its dysfunction has been…”
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Impairments in hippocampal oscillations accompany the loss of LTP induced by GIRK activity blockade
Published in Neuropharmacology (01-11-2023)“…Learning and memory occurrence requires of hippocampal long-term synaptic plasticity and precise neural activity orchestrated by brain network oscillations,…”
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Hippocampal long‐term synaptic depression and memory deficits induced in early amyloidopathy are prevented by enhancing G‐protein‐gated inwardly rectifying potassium channel activity
Published in Journal of neurochemistry (01-05-2020)“…Hippocampal synaptic plasticity disruption by amyloid‐β (Aβ) peptides + thought to be responsible for learning and memory impairments in Alzheimer's disease…”
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CPT1C is required for synaptic plasticity and oscillatory activity that supports motor, associative and non‐associative learning
Published in The Journal of physiology (01-08-2023)“…Carnitine palmitoyltransferase 1c (CPT1C) is a neuron‐specific protein widely distributed throughout the CNS and highly expressed in discrete brain areas…”
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Systematic characterization of a non-transgenic A[beta]1-42 amyloidosis model: synaptic plasticity and memory deficits in female and male mice
Published in Biology of sex differences (16-09-2023)“…Background The amyloid-[beta] (A[beta]) cascade is one of the most studied theories linked to AD. In multiple models, A[beta] accumulation and dyshomeostasis…”
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Long‐term synaptic depression and memory deficits are reversed by enhancement of GirK‐dependent signaling in a mouse model of early amyloidopathy
Published in Alzheimer's & dementia (01-12-2020)“…Background Hippocampal synaptic plasticity disruption by amyloid‐β (Aβ) peptides is thought to be responsible for learning and memory impairments in…”
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Characterization of hippocampal amyloidosis induced by amyloid‐ β in behaving mice: Developing topics
Published in Alzheimer's & dementia (01-12-2020)“…Abstract Background In early stages of Alzheimer’s disease, disruption of learning and memory processes that rely on hippocampal performance correlates with…”
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Characterization of hippocampal amyloidosis induced by amyloid‐β in behaving mice
Published in Alzheimer's & dementia (01-12-2020)“…Background In early stages of Alzheimer’s disease, disruption of learning and memory processes that rely on hippocampal performance correlates with aberrant…”
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Long‐term synaptic depression and memory deficits are reversed by enhancement of GirK‐dependent signaling in a mouse model of early amyloidopathy: Molecular and cell biology/synaptic disruption
Published in Alzheimer's & dementia (01-12-2020)“…Abstract Background Hippocampal synaptic plasticity disruption by amyloid‐ β (A β ) peptides is thought to be responsible for learning and memory impairments…”
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Systematic characterization of a non-transgenic Aβ1–42 amyloidosis model: synaptic plasticity and memory deficits in female and male mice
Published in Biology of sex differences (16-09-2023)“…Abstract Background The amyloid- β (A β ) cascade is one of the most studied theories linked to AD. In multiple models, A β accumulation and dyshomeostasis…”
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Short-term plasticity after partial deafferentation in the oculomotor system
Published in Brain Structure and Function (01-11-2019)“…Medial rectus motoneurons are innervated by two main pontine inputs. The specific function of each of these two inputs remains to be fully understood. Indeed,…”
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