Rapid method for the detection of rodenticides in contaminated foods

•Rodenticides pose significant poisoning risks to humans and animals.•Solid-liquid extraction, dispersive-solid phase cleanup was applied to food matrices.•Identification by liquid chromatography tandem mass spectrometry in negative ion mode.•Analysis method was successfully applied to a real-world...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 1186; p. 123005
Main Authors:	Okoniewski, Richard, Neely, Sarah, Denn, Melinda, Djatsa, Annie, Tran, Buu N.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-12-2021
Subjects:	Animals Anticoagulant rodenticides Brodifacoum Chromatography, High Pressure Liquid - methods Dispersive-solid phase extraction Flour - analysis Food Contamination - analysis LC-MS/MS Liver - chemistry Poisoning Rodenticides - analysis Rodenticides - isolation & purification Solid Phase Extraction - methods Swine Tandem Mass Spectrometry - methods Triticum - chemistry LC-MS/MS Anticoagulant rodenticides Poisoning Brodifacoum Dispersive-solid phase extraction
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	•Rodenticides pose significant poisoning risks to humans and animals.•Solid-liquid extraction, dispersive-solid phase cleanup was applied to food matrices.•Identification by liquid chromatography tandem mass spectrometry in negative ion mode.•Analysis method was successfully applied to a real-world contamination case study. Rodenticides are toxic chemicals used to control rodent populations and are among the most common household toxicants. Ingestion of foods contaminated with rodenticides may cause severe illness or death in humans and animals. A rapid analytical method was developed for the identification of nine common rodenticides in foods using solid–liquid extraction followed by dispersive-solid phase extraction prior to the analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and UV detection. The method validation on a variety of food matrices including cornmeal, peanut, whole wheat flour and pork liver produced average recoveries between 91.2 and 107% with relative standard deviations between 2.6 and 14% for all studied rodenticides. The method detection limits ranged from 2.7 to 8.2 μg/kg (ppb) for eight rodenticides analyzed by LC-MS/MS and between 0.10 and 0.21 mg/kg (ppm) for bromethalin which was analyzed by LC with UV detection. This method could be useful in preparedness for emergency response situations involving widespread food contamination, terrorist acts or for forensic studies.
ISSN:	1570-0232 1873-376X
DOI:	10.1016/j.jchromb.2021.123005