Understanding the Dynamics of Human Papillomavirus and Diagnostic Discrepancies in Cervical Pathology: A Single Center Experience

Understanding the Dynamics of Human Papillomavirus and Diagnostic Discrepancies in Cervical Pathology: A Single Center Experience

Cervical cancer (CC) is the most prevalent gynecological malignancy and a leading cause of death among women. It is primarily caused by human papillomavirus (HPV) infection, with 99.7% of cases showing high-risk HPV genotypes. This study sheds light on HPV dynamics as well as the discrepancies of di...

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Bibliographic Details
Published in:Diagnostics (Basel) Vol. 13; no. 24; p. 3614
Main Authors: Zamurovic, Milena, Tomic, Ana, Pikula, Aleksandra, Simanic, Sara, Knezevic, Aleksandra, Jankovic, Marko, Lackovic, Milan, Djakovic, Elena, Rovcanin, Marija
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 07-12-2023
Subjects:
Biopsy
Cellular biology
Cervical cancer
cervical dysplasia
colposcopy
cytological abnormalities
cytology
Females
Genes
Gynecology
Histopathology
Human papillomavirus
Immunization
Infections
Medical screening
Mortality
Obstetrics
Pap smear
Primary care
Questionnaires
screening
Trends
Womens health
Serbia
United States > US
colposcopy
cytology
screening
cytological abnormalities
human papillomavirus
cervical dysplasia
diagnosis
cervical cancer
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Summary:Cervical cancer (CC) is the most prevalent gynecological malignancy and a leading cause of death among women. It is primarily caused by human papillomavirus (HPV) infection, with 99.7% of cases showing high-risk HPV genotypes. This study sheds light on HPV dynamics as well as the discrepancies of different CC screening modalities results while highlighting factors that may have contributed to such a scenario. Moreover, we underscore the importance of the non-viral etiology of CC as well. We examined the current trends of HPV infection and its effects on cervical health in women treated at a tertiary care center in Belgrade, Serbia. Patients with abnormal colposcopy findings like dysplasia and re-epithelization were more likely to test negative for HPV ( < 0.001). Interestingly, women with a positive Pap smear tested HPV negative significantly more often ( = 0.041). Finally, HPV-positive individuals were more likely to have CIN I and II histologies ( < 0.001), while CIN III occurred equally in women with and without the virus. It may be inferred that inconsistencies in detecting HPV and the presence of cervical lesions may eventually result in adjustments to screening guidelines, as is crucial to adopt a meticulous approach to promote periodical CC screening, as initial samples may test negative for HPV.
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ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics13243614