Search Results - "Djaballah, H."

293 Inhibition of the cell cycle regulated Cdc7 kinase pathway is an efficacious therapeutic approach for hematologic malignancies and solid tumors by Santos, R, Shum, D, Carrillo, D, Zhang, R, Churchill, M, Mukherjee, S, Brentjens, R, Radu, C, Kelly, T.J, Djaballah, H, Frattini, M.G

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A preliminary study of the activation of endogenous pancreatic exocrine enzymes during automated porcine islet isolation by White, S A, Djaballah, H, Hughes, D P, Roberts, D L, Contractor, H H, Pathak, S, London, N J

“…The activation of endogenous pancreatic enzymes during automated pancreas digestion may be detrimental to islet isolation. In this report we assessed the…”
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A Class of Allosteric Caspase Inhibitors Identified by High-Throughput Screening by Feldman, Taya, Kabaleeswaran, Venkataraman, Jang, Se Bok, Antczak, Christophe, Djaballah, Hakim, Wu, Hao, Jiang, Xuejun

“…Caspase inhibition is a promising approach for treating multiple diseases. Using a reconstituted assay and high-throughput screening, we identified a group of…”
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The multicatalytic proteinase complex (proteasome) : structure and conformational changes associated with changes in proteolytic activity by HAKIM DJABALLAH, ROWE, A. J, HARDING, S. E, RIVETT, A. J

“…The multicatalytic proteinase complex or proteasome is a high-molecular-mass multisubunit proteinase which is found in the nucleus and cytoplasm of eukaryotic…”
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Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors by Shukla, Neerav, Somwar, Romel, Smith, Roger S, Ambati, Sri, Munoz, Stanley, Merchant, Melinda, D'Arcy, Padraig, Wang, Xin, Kobos, Rachel, Antczak, Christophe, Bhinder, Bhavneet, Shum, David, Radu, Constantin, Yang, Guangbin, Taylor, Barry S, Ng, Charlotte K Y, Weigelt, Britta, Khodos, Inna, de Stanchina, Elisa, Reis-Filho, Jorge S, Ouerfelli, Ouathek, Linder, Stig, Djaballah, Hakim, Ladanyi, Marc

“…Ewing sarcoma is a primitive round cell sarcoma with a peak incidence in adolescence that is driven by a chimeric oncogene created from the fusion of the EWSR1…”
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Reaction of proteasomes with peptidylchloromethanes and peptidyldiazomethanes by SAVORY, P. J, DJABALLAH, H, ANGLIKER, H, SHAW, E, RIVETT, A. J

“…The multicatalytic endopeptidase complex (proteasome) has multiple distinct peptidase activities. These activities have often been referred to as…”
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High-content assay to identify inhibitors of dengue virus infection by Shum, David, Smith, Jessica L, Hirsch, Alec J, Bhinder, Bhavneet, Radu, Constantin, Stein, David A, Nelson, Jay A, Früh, Klaus, Djaballah, Hakim

“…Dengue virus (DENV) infections are vectored by mosquitoes and constitute one of the most prevalent infectious diseases in many parts of the world, affecting…”
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Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47 by Ahn, K., Meyer, T. H., Uebel, S., Sempé, P., Djaballah, H., Yang, Y., Peterson, P. A., Früh, K., Tampé, R.

“…The immediate early protein ICP47 of herpes simplex virus (HSV) inhibits the transporter for antigen processing (TAP)‐mediated translocation of antigen‐derived…”
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Domain-based biosensor assay to screen for epidermal growth factor receptor modulators in live cells by Antczak, Christophe, Bermingham, Alun, Calder, Paul, Malkov, Dmitry, Song, Keming, Fetter, John, Djaballah, Hakim

“…Traditional drug discovery efforts have resulted in the approval of a handful of receptor tyrosine kinase (RTK) inhibitors; however, their discovery relied…”
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An arrayed genome-scale lentiviral-enabled short hairpin RNA screen identifies lethal and rescuer gene candidates by Bhinder, Bhavneet, Antczak, Christophe, Ramirez, Christina N, Shum, David, Liu-Sullivan, Nancy, Radu, Constantin, Frattini, Mark G, Djaballah, Hakim

“…RNA interference technology is becoming an integral tool for target discovery and validation.; With perhaps the exception of only few studies published using…”
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Identification of selective inhibitors of dedifferentiated liposarcoma cells by high-throughput screening (HTS) by Angeles, C. V., Laxa, B., Shum, D., DeCarolis, P., Gobble, R., Brill, E., Ugras, S., O'Connor, R., Djaballah, H., Singer, S.

“…Abstract only…”
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Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus protein ICP47 by Ahn, K, Meyer, TH, Uebel, S, Sempe, P, Djaballah, H, Yang, Y, Peterson, P A, Frueh, K, Tampe, R

“…The immediate early protein ICP47 of herpes simplex virus (HSV) inhibits the transporter for antigen processing (TAP)-mediated translocation of antigen derived…”
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A viral inhibitor of peptide transporters for antigen presentation by Früh, Klaus, Ahn, Kwangseog, Djaballah, Hakim, Sempé, Pascal, van Endert, Peter M, Tampé, Robert, Peterson, Per A, Yang, Young

“…Cytotoxic T lymphocytes lyse target cells after T-cell-receptor-mediated recognition of class I major histocompatibility complex molecules presenting peptides…”
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A high-throughput scintillation proximity-based assay for human DNA ligase IV by Tseng, Hui-Min, Shum, David, Bhinder, Bhavneet, Escobar, Sindy, Veomett, Nicholas J, Tomkinson, Alan E, Gin, David Y, Djaballah, Hakim, Scheinberg, David A

“…Ionizing radiation (IR) and certain chemotherapeutic drugs are designed to generate cytotoxic DNA double-strand breaks (DSBs) in cancer cells. Inhibition of…”
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An arrayed RNA interference genome-wide screen identifies candidate genes involved in the MicroRNA 21 biogenesis pathway by Shum, David, Bhinder, Bhavneet, Ramirez, Christina N, Radu, Constantin, Calder, Paul A, Beauchamp, Lesslie, Farazi, T, Landthaler, M, Tuschi, T, Magdaleno, Susan, Djaballah, Hakim

“…MicroRNAs (miRNAs) are evolutionary conserved noncoding molecules that regulate gene expression. They influence a number of diverse biological functions, such…”
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A high-throughput screen for alpha particle radiation protectants by Seideman, Jonathan H, Shum, David, Djaballah, Hakim, Scheinberg, David A

“…Alpha-particle-emitting elements are of increasing importance as environmental and occupational carcinogens, toxic components of radiation dispersal devices…”
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Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47 by Ahn, K., Meyer, T. H., Uebel, S., Sempé, P., Djaballah, H., Yang, Y., Peterson, P. A., Früh, K., Tampé, R.

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Validation of a high-content screening assay using whole-well imaging of transformed phenotypes by Ramirez, Christina N, Ozawa, Tatsuya, Takagi, Toshimitsu, Antczak, Christophe, Shum, David, Graves, Robert, Holland, Eric C, Djaballah, Hakim

“…Automated microscopy was introduced two decades ago and has become an integral part of the discovery process as a high-content screening platform with…”
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Intra-arterial and Oral Digoxin Therapy for Retinoblastoma by Patel, Mrinali, Paulus, Yannis M., Gobin, Y. Pierre, Djaballah, Hakim, Marr, Brian, Dunkel, Ira J., Brodie, Scott, Antczak, Christophe, Folberg, Robert, Abramson, David H.

“…Purpose: Preclinical studies demonstrate that cardiac glycosides such as ouabain and digoxin have antitumor effects on retinoblastoma cells in vitro and in a…”
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Antigen processing by proteasomes: insights into the molecular basis of crypticity by Djaballah, H

“…Eight to eleven amino acid residues are the sizes of predominant peptides found to be associated with MHC class I molecules. Proteasomes have been implicated…”
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