Search Results - "Dixon, Shelley A. H."

SOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2 by Mehta, Gaurav A., Angus, Steven P., Khella, Christen A., Tong, Kevin, Khanna, Pooja, Dixon, Shelley A. H., Verzi, Michael P., Johnson, Gary L., Gatza, Michael L.

“…Dysregulation of PI3K/Akt signaling is a dominant feature in basal-like or triple-negative breast cancers (TNBC). However, the mechanisms regulating this…”
Get full text

Neratinib, a pan ERBB/HER inhibitor, restores sensitivity of PTEN -null, BRAFV600E melanoma to BRAF/MEK inhibition by DuBose, Evan, Bevill, Samantha M, Mitchell, Dana K, Sciaky, Noah, Golitz, Brian T, Dixon, Shelley A H, Rhodes, Steven D, Bear, James E, Johnson, Gary L, Angus, Steven P

“…Approximately 50% of melanomas harbor an activating mutation. Standard of care involves a combination of inhibitors targeting mutant BRAF and MEK1/2, the…”
Get full text

Ravidomycin Analogs from Streptomyces sp. Exhibit Altered Antimicrobial and Cytotoxic Selectivity by Park, Kyoung Jin, Maier, Sarah, Zhang, Chengqian, Dixon, Shelley A. H., Rusch, Douglas B., Pupo, Monica T., Angus, Steven P., Gerdt, Joseph P.

“…Six new ravidomycin analogs (1–4, 6, and 7) were isolated from Streptomyces sp. Am59 using UV- and LCMS-guided separation based on Global Natural Products…”
Get full text

Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK by Chang, Long-Sheng, Oblinger, Janet L, Smith, Abbi E, Ferrer, Marc, Angus, Steven P, Hawley, Eric, Petrilli, Alejandra M, Beauchamp, Roberta L, Riecken, Lars Björn, Erdin, Serkan, Poi, Ming, Huang, Jie, Bessler, Waylan K, Zhang, Xiaohu, Guha, Rajarshi, Thomas, Craig, Burns, Sarah S, Gilbert, Thomas S K, Jiang, Li, Li, Xiaohong, Lu, Qingbo, Yuan, Jin, He, Yongzheng, Dixon, Shelley A H, Masters, Andrea, Jones, David R, Yates, Charles W, Haggarty, Stephen J, La Rosa, Salvatore, Welling, D Bradley, Stemmer-Rachamimov, Anat O, Plotkin, Scott R, Gusella, James F, Guinney, Justin, Morrison, Helen, Ramesh, Vijaya, Fernandez-Valle, Cristina, Johnson, Gary L, Blakeley, Jaishri O, Clapp, D Wade

“…Neurofibromatosis Type 2 (NF2) is an autosomal dominant genetic syndrome caused by mutations in the NF2 tumor suppressor gene resulting in multiple schwannomas…”
Get full text