Search Results - "Dixon, Matthew W. A."

Repurposing the mitotic machinery to drive cellular elongation and chromatin reorganisation in Plasmodium falciparum gametocytes by Li, Jiahong, Shami, Gerald J., Cho, Ellie, Liu, Boyin, Hanssen, Eric, Dixon, Matthew W. A., Tilley, Leann

“…The sexual stage gametocytes of the malaria parasite, Plasmodium falciparum , adopt a falciform (crescent) shape driven by the assembly of a network of…”
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Disruption of Plasmodium falciparum kinetochore proteins destabilises the nexus between the centrosome equivalent and the mitotic apparatus by Li, Jiahong, Shami, Gerald J., Liffner, Benjamin, Cho, Ellie, Braet, Filip, Duraisingh, Manoj T., Absalon, Sabrina, Dixon, Matthew W. A., Tilley, Leann

“…Plasmodium falciparum is the causative agent of malaria and remains a pathogen of global importance. Asexual blood stage replication, via a process called…”
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Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development by Parkyn Schneider, Molly, Liu, Boyin, Glock, Philipp, Suttie, Annika, McHugh, Emma, Andrew, Dean, Batinovic, Steven, Williamson, Nicholas, Hanssen, Eric, McMillan, Paul, Hliscs, Marion, Tilley, Leann, Dixon, Matthew W A

“…Transmission of malaria parasites relies on the formation of a specialized blood form called the gametocyte. Gametocytes of the human pathogen, Plasmodium…”
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The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly by Looker, Oliver, Blanch, Adam J, Liu, Boyin, Nunez-Iglesias, Juan, McMillan, Paul J, Tilley, Leann, Dixon, Matthew W A

“…Plasmodium falciparum mediates adhesion of infected red blood cells (RBCs) to blood vessel walls by assembling a multi-protein complex at the RBC surface. This…”
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PfCERLI1 is a conserved rhoptry associated protein essential for Plasmodium falciparum merozoite invasion of erythrocytes by Liffner, Benjamin, Frölich, Sonja, Heinemann, Gary K., Liu, Boyin, Ralph, Stuart A., Dixon, Matthew W. A., Gilberger, Tim-Wolf, Wilson, Danny W.

“…The disease-causing blood-stage of the Plasmodium falciparum lifecycle begins with invasion of human erythrocytes by merozoites. Many vaccine candidates with…”
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Deletion of the Plasmodium falciparum exported protein PTP7 leads to Maurer’s clefts vesiculation, host cell remodeling defects, and loss of surface presentation of EMP1 by Carmo, Olivia M. S, Shami, Gerald J, Cox, Dezerae, Liu, Boyin, Blanch, Adam J, Tiash, Snigdha, Tilley, Leann, Dixon, Matthew W. A

“…Presentation of the variant antigen, Plasmodium falciparum erythrocyte membrane protein 1 (EMP1), at knob-like protrusions on the surface of infected red blood…”
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Reversible host cell remodeling underpins deformability changes in malaria parasite sexual blood stages by Dearnley, Megan, Chu, Trang, Zhang, Yao, Looker, Oliver, Huang, Changjin, Klonis, Nectarios, Yeoman, Jeff, Kenny, Shannon, Arora, Mohit, Osborne, James M., Chandramohanadas, Rajesh, Zhang, Sulin, Dixon, Matthew W. A., Tilley, Leann

“…The sexual blood stage of the human malaria parasite Plasmodium falciparum undergoes remarkable biophysical changes as it prepares for transmission to…”
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The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites by Charnaud, Sarah C, Dixon, Matthew W A, Nie, Catherine Q, Chappell, Lia, Sanders, Paul R, Nebl, Thomas, Hanssen, Eric, Berriman, Matthew, Chan, Jo-Anne, Blanch, Adam J, Beeson, James G, Rayner, Julian C, Przyborski, Jude M, Tilley, Leann, Crabb, Brendan S, Gilson, Paul R

“…Malaria is caused by five different Plasmodium spp. in humans each of which modifies the host erythrocyte to survive and replicate. The two main causes of…”
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Bio-sensing with butterfly wings: naturally occurring nano-structures for SERS-based malaria parasite detection by Garrett, Natalie L, Sekine, Ryo, Dixon, Matthew W A, Tilley, Leann, Bambery, Keith R, Wood, Bayden R

“…Surface enhanced Raman scattering (SERS) is a powerful tool with great potential to provide improved bio-sensing capabilities. The current 'gold-standard'…”
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Origin, composition, organization and function of the inner membrane complex of Plasmodium falciparum gametocytes by Dearnley, Megan K, Yeoman, Jeffrey A, Hanssen, Eric, Kenny, Shannon, Turnbull, Lynne, Whitchurch, Cynthia B, Tilley, Leann, Dixon, Matthew W A

“…The most virulent of the human malaria parasites, Plasmodium falciparum, undergoes a remarkable morphological transformation as it prepares itself for sexual…”
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Contrasting Inducible Knockdown of the Auxiliary PTEX Component PTEX88 in P. falciparum and P. berghei Unmasks a Role in Parasite Virulence by Chisholm, Scott A, McHugh, Emma, Lundie, Rachel, Dixon, Matthew W A, Ghosh, Sreejoyee, O'Keefe, Meredith, Tilley, Leann, Kalanon, Ming, de Koning-Ward, Tania F

“…Pathogenesis of malaria infections is linked to remodeling of erythrocytes, a process dependent on the trafficking of hundreds of parasite-derived proteins…”
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Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells by Akter, Jasmin, Khoury, David S, Aogo, Rosemary, Lansink, Lianne I M, SheelaNair, Arya, Thomas, Bryce S, Laohamonthonkul, Pawat, Pernold, Clara P S, Dixon, Matthew W A, Soon, Megan S F, Fogg, Lily G, Engel, Jessica A, Elliott, Trish, Sebina, Ismail, James, Kylie R, Cromer, Deborah, Davenport, Miles P, Haque, Ashraful

“…Plasmodium parasites invade and multiply inside red blood cells (RBC). Through a cycle of maturation, asexual replication, rupture and release of multiple…”
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Effect of Antimalarial Drugs on Plasmodium falciparum Gametocytes by Peatey, Christopher L., Skinner-Adams, Tina S., Dixon, Matthew W. A., McCarthy, James S., Gardiner, Donald L., Trenholme, Katharine R.

“…Gametocytes are the sexual stage of the malaria parasite and are essential for transmission to the mosquito. Antimalarial drugs have been reported to affect…”
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Spatial and temporal mapping of the PfEMP1 export pathway in Plasmodium falciparum by McMillan, Paul J., Millet, Coralie, Batinovic, Steven, Maiorca, Mauro, Hanssen, Eric, Kenny, Shannon, Muhle, Rebecca A., Melcher, Martin, Fidock, David A., Smith, Joseph D., Dixon, Matthew W. A., Tilley, Leann

“…Summary The human malaria parasite, Plasmodium falciparum, modifies the red blood cells (RBCs) that it infects by exporting proteins to the host cell. One key…”
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The Plasmodium translocon of exported proteins (PTEX) component thioredoxin‐2 is important for maintaining normal blood‐stage growth by Matthews, Kathryn, Kalanon, Ming, Chisholm, Scott A., Sturm, Angelika, Goodman, Christopher D., Dixon, Matthew W. A., Sanders, Paul R., Nebl, Thomas, Fraser, Fiona, Haase, Silvia, McFadden, Geoffrey I., Gilson, Paul R., Crabb, Brendan S., Koning‐Ward, Tania F.

“…Summary Plasmodium parasites remodel their vertebrate host cells by translocating hundreds of proteins across an encasing membrane into the host cell cytosol…”
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Diagnosing malaria infected cells at the single cell level using focal plane array Fourier transform infrared imaging spectroscopy by Wood, Bayden R, Bambery, Keith R, Dixon, Matthew W A, Tilley, Leann, Nasse, Michael J, Mattson, Eric, Hirschmugl, Carol J

“…New methods are needed to rapidly identify malaria parasites in blood smears. The coupling of a Focal Plane Array (FPA) infrared microscope system to a…”
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Red Blood Cells Polarize Green Laser Light Revealing Hemoglobin's Enhanced Non-Fundamental Raman Modes by MARZEC, Katarzyna M, PEREZ-GUAITA, David, DE VEIJ, Marleen, McNAUGHTON, Don, BARANSKA, Malgorzata, DIXON, Matthew W. A, TILLEY, Leann, WOOD, Bayden R

“…In general, the first overtone modes produce weak bands that appear at approximately twice the wavenumber value of the fundamental transitions in vibrational…”
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Plasmodium falciparum formins are essential for invasion and sexual stage development by Collier, Sophie, Pietsch, Emma, Dans, Madeline, Ling, Dawson, Tavella, Tatyana A., Lopaticki, Sash, Marapana, Danushka S., Shibu, Mohini A., Andrew, Dean, Tiash, Snigdha, McMillan, Paul J., Gilson, Paul, Tilley, Leann, Dixon, Matthew W. A.

“…The malaria parasite uses actin-based mechanisms throughout its lifecycle to control a range of biological processes including intracellular trafficking, gene…”
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A repeat sequence domain of the ring‐exported protein‐1 of Plasmodium falciparum controls export machinery architecture and virulence protein trafficking by McHugh, Emma, Batinovic, Steven, Hanssen, Eric, McMillan, Paul J., Kenny, Shannon, Griffin, Michael D. W., Crawford, Simon, Trenholme, Katharine R., Gardiner, Donald L., Dixon, Matthew W. A., Tilley, Leann

“…Summary The malaria parasite Plasmodium falciparum dramatically remodels its host red blood cell to enhance its own survival, using a secretory membrane system…”
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Plasmodium species: master renovators of their host cells by de Koning-Ward, Tania F., Dixon, Matthew W.A., Tilley, Leann, Gilson, Paul R.

“…Key Points The capacity of Plasmodium parasites to extensively remodel the erythrocytes in which they reside is fundamental to their ability to survive within…”
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