Search Results - "Dixon, Darryl D"

A New Reagent for Direct Difluoromethylation by Fujiwara, Yuta, Dixon, Janice A, Rodriguez, Rodrigo A, Baxter, Ryan D, Dixon, Darryl D, Collins, Michael R, Blackmond, Donna G, Baran, Phil S

“…Molecular scaffolds containing alkylfluorine substituents are desired in many areas of chemical research from materials to pharmaceuticals. Herein, we report…”
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Practical and innate carbon–hydrogen functionalization of heterocycles by Fujiwara, Yuta, Dixon, Janice A., O’Hara, Fionn, Funder, Erik Daa, Dixon, Darryl D., Rodriguez, Rodrigo A., Baxter, Ryan D., Herlé, Bart, Sach, Neal, Collins, Michael R., Ishihara, Yoshihiro, Baran, Phil S.

“…It is shown that zinc sulphinate salts can be used to transfer alkyl radicals to heterocycles, allowing for the mild, direct and operationally simple formation…”
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CH Functionalization Logic Enables Synthesis of (+)-Hongoquercin A and Related Compounds by Rosen, Brandon R., Simke, Leah R., Thuy-Boun, Peter S., Dixon, Darryl D., Yu, Jin-Quan, Baran, Phil S.

“…The specifics: A synthesis of the sesquiterpenoid antibiotic (+)‐hongoquercin A using sequential site‐specific CH methylation and oxidation reactions is…”
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The Evolution of the Total Synthesis of Rocaglamide by Zhou, Zhe, Dixon, Darryl D., Jolit, Anais, Tius, Marcus A.

“…The complex flavagline, (−)‐rocaglamide, possesses a synthetically intriguing tricyclic scaffold with five contiguous stereocenters and also exhibits potent…”
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Redox-Active Esters in Fe-Catalyzed C–C Coupling by Toriyama, Fumihiko, Cornella, Josep, Wimmer, Laurin, Chen, Tie-Gen, Dixon, Darryl D, Creech, Gardner, Baran, Phil S

“…Cross-couplings of alkyl halides and organometallic species based on single electron transfer using Ni and Fe catalyst systems have been studied extensively,…”
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C3-Heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor by Dixon, Darryl D., Tius, Marcus A., Thakur, Ganesh A., Zhou, Han, Bowman, Anna L., Shukla, Vidyanand G., Peng, Yan, Makriyannis, Alexandros

“…A series of tricyclic cannabinoids incorporating a heteroaroyl group at C3 were prepared as probes to explore the binding site(s) of the CB1 and CB2 receptors…”
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Practical Radical Cyclizations with Arylboronic Acids and Trifluoroborates by Lockner, Jonathan W, Dixon, Darryl D, Risgaard, Rune, Baran, Phil S

“…Practical radical cyclizations using organoboronic acids and trifluoroborates take place in water, open to air, and in a scalable fashion employing catalytic…”
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3‑[(1S,2S,3R)‑2,3-Difluoro-1-hydroxy-7-methylsulfonyl­indan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma by Xu, Rui, Wang, Keshi, Rizzi, James P, Huang, Heli, Grina, Jonas A, Schlachter, Stephen T, Wang, Bin, Wehn, Paul M, Yang, Hanbiao, Dixon, Darryl D, Czerwinski, Robert M, Du, Xinlin, Ged, Emily L, Han, Guangzhou, Tan, Huiling, Wong, Tai, Xie, Shanhai, Josey, John A, Wallace, Eli M

“…The hypoxia-inducible factor 2α (HIF-2α) is a key oncogenic driver in clear cell renal cell carcinoma (ccRCC). Our first HIF-2α inhibitor PT2385 demonstrated…”
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A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma by Wallace, Eli M, Rizzi, James P, Han, Guangzhou, Wehn, Paul M, Cao, Zhaodan, Du, Xinlin, Cheng, Tzuling, Czerwinski, Robert M, Dixon, Darryl D, Goggin, Barry S, Grina, Jonas A, Halfmann, Megan M, Maddie, Melissa A, Olive, Sarah R, Schlachter, Stephen T, Tan, Huiling, Wang, Bin, Wang, Keshi, Xie, Shanhai, Xu, Rui, Yang, Hanbiao, Josey, John A

“…More than 90% of clear cell renal cell carcinomas (ccRCC) exhibit inactivation of the von Hippel-Lindau (pVHL) tumor suppressor, establishing it as the major…”
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Scalable, Divergent Synthesis of Meroterpenoids via “Borono-sclareolide” by Dixon, Darryl D, Lockner, Jonathan W, Zhou, Qianghui, Baran, Phil S

“…A scalable, divergent synthesis of bioactive meroterpenoids has been developed. A key component of this work is the invention of “borono-sclareolide”, a…”
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Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385) by Wehn, Paul M, Rizzi, James P, Dixon, Darryl D, Grina, Jonas A, Schlachter, Stephen T, Wang, Bin, Xu, Rui, Yang, Hanbiao, Du, Xinlin, Han, Guangzhou, Wang, Keshi, Cao, Zhaodan, Cheng, Tzuling, Czerwinski, Robert M, Goggin, Barry S, Huang, Heli, Halfmann, Megan M, Maddie, Melissa A, Morton, Emily L, Olive, Sarah R, Tan, Huiling, Xie, Shanhai, Wong, Tai, Josey, John A, Wallace, Eli M

“…HIF-2α, a member of the HIF family of transcription factors, is a key oncogenic driver in cancers such as clear cell renal cell carcinoma (ccRCC). A signature…”
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Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)‑3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro‑1H‑inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385) by Wehn, Paul M, Rizzi, James P, Dixon, Darryl D, Grina, Jonas A, Schlachter, Stephen T, Wang, Bin, Xu, Rui, Yang, Hanbiao, Du, Xinlin, Han, Guangzhou, Wang, Keshi, Cao, Zhaodan, Cheng, Tzuling, Czerwinski, Robert M, Goggin, Barry S, Huang, Heli, Halfmann, Megan M, Maddie, Melissa A, Morton, Emily L, Olive, Sarah R, Tan, Huiling, Xie, Shanhai, Wong, Tai, Josey, John A, Wallace, Eli M

“…HIF-2α, a member of the HIF family of transcription factors, is a key oncogenic driver in cancers such as clear cell renal cell carcinoma (ccRCC). A signature…”
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Direct Lewis Acid Catalyzed Conversion of Enantioenriched N‑Acyloxazolidinones to Chiral Esters, Amides, and Acids by Stevens, Jason M, Parra-Rivera, Ana Cristina, Dixon, Darryl D, Beutner, Gregory L, DelMonte, Albert J, Frantz, Doug E, Janey, Jacob M, Paulson, James, Talley, Michael R

“…The identification of Yb­(OTf)3 through a multivariable high-throughput experimentation strategy has enabled a unified protocol for the direct conversion of…”
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Revisiting the Cleavage of Evans Oxazolidinones with LiOH/H2O2 by Beutner, Gregory L, Cohen, Benjamin M, DelMonte, Albert J, Dixon, Darryl D, Fraunhoffer, Kenneth J, Glace, Andrew W, Lo, Ehrlic, Stevens, Jason M, Vanyo, Dale, Wilbert, Christopher

“…The use of LiOH/H2O2 for cleavage of Evans oxazolidinones is an essential but often overlooked part of using these ubiquitous chiral auxiliaries in synthetic…”
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Rapid Development of a Commercial Process for Linrodostat, an Indoleamine 2,3-Dioxygenase (IDO) Inhibitor by Fraunhoffer, Kenneth J, DelMonte, Albert J, Beutner, Gregory L, Bultman, Michael S, Camacho, Kathryn, Cohen, Benjamin, Dixon, Darryl D, Fan, Yu, Fanfair, Dayne, Freitag, Adam J, Glace, Andrew W, Gonzalez-Bobes, Francisco, Gujjar, Manjunath, Haley, Matthew W, Hickey, Matthew R, Ho, Jeanne, Iyer, Vidya, Maity, Prantik, Patel, Sunil, Rosso, Victor W, Schmidt, Michael A, Stevens, Jason M, Tan, Yichen, Wilbert, Christopher, Young, Ian S, Yu, Miao

“…The process development and the kilogram-scale synthesis of linrodostat (BMS-986205, 1) are described. The synthesis features several highly efficient…”
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Safe Scale-up of an Oxygen-Releasing Cleavage of Evans Oxazolidinone with Hydrogen Peroxide by Glace, Andrew W, Cohen, Benjamin M, Dixon, Darryl D, Beutner, Gregory L, Vanyo, Dale, Akpinar, Fulya, Rosso, Victor, Fraunhoffer, Kenneth J, DelMonte, Albert J, Santana, Edgar, Wilbert, Christopher, Gallo, Frank, Bartels, William

“…In the pharmaceutical industry, H2O2-mediated oxidation reactions are commonly used in chemical syntheses but they can also introduce unexpected safety…”
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A Mild, Functional Group Tolerant Addition of Organozinc Nucleophiles to N‑Activated Quinolines and Isoquinolines by Luzung, Michael R, Dixon, Darryl D, Ortiz, Adrian, Guerrero, Carlos A, Ayers, Sloan, Ho, Jeanne, Schmidt, Michael A, Strotman, Neil A, Eastgate, Martin D

“…An addition of organozinc nucleophiles to N-acyl activated quinolines and isoquinolines is described. Simple transmetalation with the corresponding Grignard…”
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A simple procedure for C–C bond cleavage of aromatic and aliphatic epoxides with aqueous sodium periodate under ambient conditions by Binder, Caitlin M., Dixon, Darryl D., Almaraz, Erik, Tius, Marcus A., Singaram, Bakthan

“…The sodium periodate mediated oxidative cleavage of the C–C bond of 12 epoxides is reported with yields of the corresponding carbonyl compounds in up to 91%…”
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Heteroadamantyl Cannabinoids by Dixon, Darryl D, Sethumadhavan, Divakaramenon, Benneche, Tore, Banaag, April R, Tius, Marcus A, Thakur, Ganesh A, Bowman, Anna, Wood, JodiAnne T, Makriyannis, Alexandros

“…The aliphatic side chain plays a pivotal role in determining the cannabinergic potency of tricyclic classical cannabinoids. We have synthesized a series of…”
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Gas Phase and Solution Structures of 1-Methoxyallenyllithium by Dixon, Darryl D, Tius, Marcus A, Pratt, Lawrence M

“…A combined computational and 13C NMR study was used to determine the solution structures of 1-methoxyallenyllithium. The gas phase calculations indicated that…”
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