Search Results - "Dixon, Ann"

The cell edit: Looking at and beyond non-structural proteins to understand membrane rearrangement in coronaviruses by Denker, Lea, Dixon, Ann M

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-stranded RNA virus that sits at the centre of the recent global pandemic. As a…”
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Characterization of interactions within the Igα/Igβ transmembrane domains of the human B-cell receptor provides insights into receptor assembly by Lockey, Christine, Young, Hannah, Brown, Jessica, Dixon, Ann M.

“…The B-cell receptor (BCR), a complex comprised of a membrane-associated immunoglobulin and the Igα/β heterodimer, is one of the most important immune receptors…”
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Role of membrane environment and membrane-spanning protein regions in assembly and function of the Class II Major Histocompatibility complex by Dixon, Ann M., Roy, Syamal

“…Class II Major Histocompatibility complex (MHC-II) is a polymorphic heterodimer that binds antigen-derived peptides and presents them on the surface of antigen…”
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Working across space and time: nonstationarity in ecological research and application by Rollinson, Christine R, Finley, Andrew O, Alexander, M Ross, Banerjee, Sudipto, Hamil, Kelly-Ann Dixon, Koenig, Lauren E, Locke, Dexter Henry, Peterson, Megan, Tingley, Morgan W, Wheeler, Kathryn, Youngflesh, Casey, Zipkin, Elise F

“…Ecological research increasingly considers integrative relationships among phenomena at broad spatial and temporal domains. However, such large-scale…”
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Revealing the mechanism of protein-lipid interactions for a putative membrane curvature sensor in plant endoplasmic reticulum by Brooks, Rhiannon L., Dixon, Ann M.

“…Membrane curvature sensing via helical protein domains, such as those identified in Amphiphysin and ArfGAP1, have been linked to a diverse range of cellular…”
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Differential pairing of transmembrane domain GxxxG dimerization motifs defines two HLA-DR MHC class II conformers by Drake, Lisa A., Hahn, Amy B., Dixon, Ann M., Drake, James R.

“…MHC class II molecules function to present exogenous antigen-derived peptides to CD4 T cells to both drive T cell activation and to provide signals back into…”
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Lipid bilayers as potential ice nucleating agents by Miles, Christopher M, Hsu, Pin-Chia, Dixon, Ann M, Khalid, Syma, Sosso, Gabriele C

“…Cellular damage is a key issue in the context of cryopreservation. Much of this damage is believed to be caused by extracellular ice formation at temperatures…”
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Curvature sensing amphipathic helix in the C-terminus of RTNLB13 is conserved in all endoplasmic reticulum shaping reticulons in Arabidopsis thaliana by Brooks, Rhiannon L., Mistry, Chandni S., Dixon, Ann M.

“…The reticulon family of integral membrane proteins are conserved across all eukaryotes and typically localize to the endoplasmic reticulum (ER), where they are…”
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Synthesis and Functionalization of Azetidine‐Containing Small Macrocyclic Peptides by Saunders, George J., Spring, Sam A., Jayawant, Eleanor, Wilkening, Ina, Roesner, Stefan, Clarkson, Guy J., Dixon, Ann M., Notman, Rebecca, Shipman, Michael

“…Cyclic peptides are increasingly important structures in drugs but their development can be impeded by difficulties associated with their synthesis. Here, we…”
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De novo design of transmembrane helix–helix interactions and measurement of stability in a biological membrane by Nash, Anthony, Notman, Rebecca, Dixon, Ann M.

“…Membrane proteins regulate a large number of cellular functions, and have great potential as tools for manipulation of biological systems. Developing these…”
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Characterisation of the Carboxypeptidase G2 Catalytic Site and Design of New Inhibitors for Cancer Therapy by Jeyaharan, Dhadchayini, Brackstone, Carla, Schouten, James, Davis, Paul, Dixon, Ann M.

“…The enzyme carboxypeptidase G2 (CPG2) is used in antibody‐directed enzyme prodrug therapy (ADEPT) to catalyse the formation of an active drug from an inert…”
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Towards detection of structurally-diverse glycated epitopes in native proteins: Single-chain antibody directed to non-A1c epitope in human haemoglobin by Gaetani, Miss Lucia, Pinto, Isabel Campos, Li, Meng, O’Connor, Peter, Giorgi-Coll, Susan, Tyreman, Matthew, Rumary, Katherine L., Schouten, James A., Davis, Paul, Dixon, Ann M.

“…Over 500 million people worldwide are affected by diabetes mellitus, a chronic disease that leads to high blood glucose levels and causes severe side effects…”
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The Extracellular Domain of Two-component System Sensor Kinase VanS from Streptomyces coelicolor Binds Vancomycin at a Newly Identified Binding Site by Lockey, Christine, Edwards, Richard J., Roper, David I., Dixon, Ann M.

“…The glycopeptide antibiotic vancomycin has been widely used to treat infections of Gram-positive bacteria including Clostridium difficile and…”
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Macrocyclisation of small peptides enabled by oxetane incorporation by Roesner, Stefan, Saunders, George J, Wilkening, Ina, Jayawant, Eleanor, Geden, Joanna V, Kerby, Paul, Dixon, Ann M, Notman, Rebecca, Shipman, Michael

“…Cyclic peptides are an important source of new drugs but are challenging to produce synthetically. We show that head-to-tail peptide macrocyclisations are…”
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The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix by Barneda, David, Planas-Iglesias, Joan, Gaspar, Maria L, Mohammadyani, Dariush, Prasannan, Sunil, Dormann, Dirk, Han, Gil-Soo, Jesch, Stephen A, Carman, George M, Kagan, Valerian, Parker, Malcolm G, Ktistakis, Nicholas T, Klein-Seetharaman, Judith, Dixon, Ann M, Henry, Susan A, Christian, Mark

“…Maintenance of energy homeostasis depends on the highly regulated storage and release of triacylglycerol primarily in adipose tissue, and excessive storage is…”
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Impact of oxetane incorporation on the structure and stability of alpha-helical peptides by Jayawant, Eleanor S, Beadle, Jonathan D, Wilkening, Ina, Raubo, Piotr, Shipman, Michael, Notman, Rebecca, Dixon, Ann M

“…Peptide-based drugs combine advantages of larger biological therapeutics with those of small molecule drugs, but they generally display poor permeability and…”
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Exploring patient involvement in healthcare decision making across different education and functional health literacy groups by Smith, Sian K., Dixon, Ann, Trevena, Lyndal, Nutbeam, Don, McCaffery, Kirsten J.

“…Education and health literacy potentially limit a person's ability to be involved in decisions about their health. Few studies, however, have explored…”
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Effective Relationships Between Younger Caregivers and Older Care Recipients Across a Continuum of Formal Residential Care Settings: A Scoping Review and a Critical Analysis by Dixon, Carol-Ann, Roos, Vera, Katjene, Matthews, Hoffman, Jaco

“…This article aims to conduct a scoping review of what constitutes effective relational interactions between caregivers (CGs) and older persons (OPs) across…”
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Molecular Basis of Selectivity and Activity for the Antimicrobial Peptide Lynronne‐1 Informs Rational Design of Peptide with Improved Activity by Jayawant, Eleanor S., Hutchinson, Jack, Gašparíková, Dorota, Lockey, Christine, Pruñonosa Lara, Lidón, Guy, Ciaran, Brooks, Rhiannon L., Dixon, Ann M.

“…Antibiotic resistance is a significant threat to human health, with natural products remaining the best source for new antimicrobial compounds. Antimicrobial…”
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A C-terminal amphipathic helix is necessary for the in vivo tubule-shaping function of a plant reticulon by Breeze, Emily, Dzimitrowicz, Natasha, Kriechbaumer, Verena, Brooks, Rhiannon, Botchway, Stanley W., Brady, Jacob P., Hawes, Chris, Dixon, Ann M., Schnell, Jason R., Fricker, Mark D., Frigerio, Lorenzo

“…Reticulons (RTNs) are a class of endoplasmic reticulum (ER) membrane proteins that are capable of maintaining high membrane curvature, thus helping shape the…”
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