Search Results - "Dix, Ina"

Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers by Nishiguchi, Gisele A, Rico, Alice, Tanner, Huw, Aversa, Robert J, Taft, Benjamin R, Subramanian, Sharadha, Setti, Lina, Burger, Matthew T, Wan, Lifeng, Tamez, Victoriano, Smith, Aaron, Lou, Yan, Barsanti, Paul A, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Dix, Ina, Tellew, John E, Huang, Shenlin, Mathews Griner, Lesley A, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Ma, Sylvia, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Jansen, Johanna M, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Lees, Emma, Shao, Wenlin, Stuart, Darrin D, Dillon, Michael P, Ramurthy, Savithri

“…RAS oncogenes have been implicated in >30% of human cancers, all representing high unmet medical need. The exquisite dependency on CRAF kinase in KRAS mutant…”
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Lead Optimization of Spiropyrazolopyridones: A New and Potent Class of Dengue Virus Inhibitors by Zou, Bin, Chan, Wai Ling, Ding, Mei, Leong, Seh Yong, Nilar, Shahul, Seah, Peck Gee, Liu, Wei, Karuna, Ratna, Blasco, Francesca, Yip, Andy, Chao, Alex, Susila, Agatha, Dong, Hongping, Wang, Qing Yin, Xu, Hao Ying, Chan, Katherine, Wan, Kah Fei, Gu, Feng, Diagana, Thierry T, Wagner, Trixie, Dix, Ina, Shi, Pei-Yong, Smith, Paul W

“…Spiropyrazolopyridone 1 was identified, as a novel dengue virus (DENV) inhibitor, from a DENV serotype 2 (DENV-2) high-throughput phenotypic screen. As a…”
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(+)-Flavipucine, the Missing Member of the Pyridione Epoxide Family of Fungal Antibiotics by Loesgen, Sandra, Bruhn, Torsten, Meindl, Kathrin, Dix, Ina, Schulz, Barbara, Zeeck, Axel, Bringmann, Gerhard

“…From the culture extracts of the endophytic fungus, Phoma sp., isolated from the plant Salsola oppositifolia, five secondary metabolites were isolated and…”
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Preparation, Structural Properties and Thermal Isomerization of Hex-3-ene-1,5-diyne Bridged [2.2]Paracyclophanes by Dix, Ina, Bondarenko, Lidija, Jones, Peter G., Ernst, Ludger, Ibrom, Kerstin, Grunenberg, Jörg, Boese, Roland, Hopf, Henning

“…The [2.2]paracyclophane moiety is used as a spacer to connect the ends of a hex‐3‐ene‐1,5‐diyne unit, a π‐system that on thermolysis usually cycloaromatizes to…”
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MP2 and DFT Calculations on Circulenes and an Attempt to Prepare the Second Lowest Benzolog, [4]Circulene by Christoph, Hilmar, Grunenberg, Jörg, Hopf, Henning, Dix, Ina, Jones, Peter G., Scholtissek, Martin, Maier, Günther

“…MP2 and DFT calculations have been carried out for [n]circulenes for n=3 to 20 in order to predict the strain energy and topology of these cyclically condensed…”
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Bulky N-Substituted 1,3-Benzazaphospholes: Access via Pd-Catalyzed C−N and C−P Cross Coupling, Lithiation, and Conversion to Novel PC−PtBu2 Hybrid Ligands by Aluri, Bhaskar Reddy, Kindermann, Markus K, Jones, Peter G, Dix, Ina, Heinicke, Joachim

“…The syntheses of novel bulky N-substituted 1,3-benzazaphospholes are presented, together with their reactions with tert-butyllithium and coupling with tBu2PCl…”
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Building complex carbon skeletons with ethynyl[2.2]paracyclophanes by Dix, Ina, Bondarenko, Lidija, Jones, Peter G, Oeser, Thomas, Hopf, Henning

“…Ethynyl[2.2]paracyclophanes are shown to be useful substrates for the preparation of complex, highly unsaturated carbon frameworks. Thus both the…”
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Discovery of Tetrahydropyrazolopyrimidine Carboxamide Derivatives As Potent and Orally Active Antitubercular Agents by Yokokawa, Fumiaki, Wang, Gang, Chan, Wai Ling, Ang, Shi Hua, Wong, Josephine, Ma, Ida, Rao, Srinivasa P S, Manjunatha, Ujjini, Lakshminarayana, Suresh B, Herve, Maxime, Kounde, Cyrille, Tan, Bee Huat, Thayalan, Pamela, Ng, Seow Hwee, Nanjundappa, Mahesh, Ravindran, Sindhu, Gee, Peck, Tan, Maria, Wei, Liu, Goh, Anne, Chen, Pei-Yu, Lee, Kok Sin, Zhong, Chen, Wagner, Trixie, Dix, Ina, Chatterjee, Arnab K, Pethe, Kevin, Kuhen, Kelli, Glynne, Richard, Smith, Paul, Bifani, Pablo, Jiricek, Jan

“…Tetrahydropyrazolo[1,5-a]pyrimidine scaffold was identified as a hit series from a Mycobacterium tuberculosis (Mtb) whole cell high through-put screening (HTS)…”
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The chemical behavior of terminally tert-butylated polyolefins by Klein, Dagmar, Hopf, Henning, Jones, Peter G, Dix, Ina, Hänel, Ralf

“…The chemical behavior of various oligoenes 2 has been studied. The catalytic hydrogenation of diene 3 yielded monoene 4. Triene 7 was hydrogenated to diene 8,…”
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The preparation of several 1,2,3,4,5-functionalized cyclopentane derivatives by Kelch, André S, Jones, Peter G, Dix, Ina, Hopf, Henning

“…With the goal of eventually synthesizing [5]radialene (3), the still missing member of the parent radialene hydrocarbons, we have prepared the pentaacetates 21…”
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Preparation and NMR spectra of four isomeric diformyl[2.2]paracyclophanes (cyclophanes 66) by Dix, Ina, Hopf, Henning, Satyanarayana, Thota B N, Ernst, Ludger

“…Four isomeric dialdehydes 4, readily available from cycloaddition of propiolic aldehyde (2) to 1,2,4,5-hexatetraene (1), were separated by chromatography and…”
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1,x-Elimination Reactions: Extending the Limits of a Classical Organic Reaction by Werner, Christian, Hopf, Henning, Dix, Ina, Bubenitschek, Peter, Jones, Peter G.

“…α,ω‐Dibromo derivatives in which the two terminal carbon atom are separated by an unsaturated spacer unit (“π spacer”) undergo 1,x‐elimination reactions (with…”
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Intramolecular Reactions in Pseudo-Geminally Substituted [2.2]Paracyclophanes by Bondarenko, Lidija, Hentschel, Silke, Greiving, Helmut, Grunenberg, Jörg, Hopf, Henning, Dix, Ina, Jones, Peter G., Ernst, Ludger

“…A selection of pseudo‐geminally substituted [2.2]paracyclophanes, the alkynes 6, 7, 10, 11 a, and 11 b and the alkenes 8 and 9 were prepared for the study of…”
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Cycloadditions to Alkenyl[2.2]paracyclophanes by Aly, Ashraf A., Ehrhardt, Sonja, Hopf, Henning, Dix, Ina, Jones, Peter G.

“…Cycloadditions between the 4‐alkenyl[2.2]paracyclophanes 7, 16–21 and the dienophiles 10a–h have been studied. Whereas 10a, b, d, and g prefer Diels–Alder…”
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4,15-Diamino[2.2]paracyclophane, a Reusable Template for Topochemical Reaction Control in Solution by Zitt, Holger, Dix, Ina, Hopf, Henning, Jones, Peter G.

“…An efficient synthesis of [2.2]paracyclophane‐4,15‐dicarboxylic acid (11) from [2.2]paracyclophane (8) has been developed. The diacid was converted via the…”
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Design of a Neutral Macrocyclic Ionophore: Synthesis and Binding Properties for Nitrate and Bromide Anions by Herges, Rainer, Dikmans, Anton, Jana, Umasish, Köhler, Felix, Jones, Peter G., Dix, Ina, Fricke, Tom, König, Burkhard

“…A macrocyclic neutral ionophore 8 (X = O) capable of binding weakly coordinating anions such as nitrate and bromide in DMSO solution has been designed by a…”
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Sr5(VIVOF5)3F(H2O)3 refined from a non-merohedrally twinned crystal by Le Bail, Armel, Mercier, Anne-Marie, Dix, Ina

“…The title compound, penta­strontium tris­[penta­fluorido­oxido­vanadate(IV)] fluoride trihydrate, was obtained under hydro­thermal conditions. Its crystal…”
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Spin-Spin Interactions Across the "Cove" in the (Z) and (E) Isomers of 1,1′-Difluoro-9,9′-bifluorenylidene by Krcsmar, Lidia, Grunenberg, Jörg, Dix, Ina, Jones, Peter G., Ibrom, Kerstin, Ernst, Ludger

“…In the (Z) isomer, but not in the (E) isomer of title compound 1, moderate 19F,19F spin–spin coupling across the “cove” is observed [J(F,F) = 11.0 Hz], which…”
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The Ru(II)-supported heptatungstates [HXW7O28Ru(dmso)3]6-(X=P, As) by Bi, Li-Hua, Dickman, Michael H, Kortz, Ulrich, Dix, Ina

“…The ruthenium(II)-supported heteropolyanions [HXW7O28Ru(dmso)3]6-(X=P, 1; As, 2) are composed of a Ru(dmso)3 group attached to an unprecedented heptatungstate…”
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Model Reactions for the Synthesis of Azacorannulenes and Related Heteroaromatic Compounds by Dix, Ina, Doll, Christian, Hopf, Henning, Jones, Peter G.

“…4‐(2‐Ethynylphenyl)pyridine (10), 3‐(2‐ethynylphenyl)pyridine (11), 2‐(2‐trimethylsilylethynylphenyl)pyridine (26), and 3‐ethynyl‐2‐phenylpyridine (13) were…”
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