Search Results - "Diwan, Bhalchandra"

Metallothionein protection of cadmium toxicity by Klaassen, Curtis D., Liu, Jie, Diwan, Bhalchandra A.

“…The discovery of the cadmium (Cd)-binding protein from horse kidney in 1957 marked the birth of research on this low-molecular weight, cysteine-rich protein…”
Get full text

Proline Oxidase Functions as a Mitochondrial Tumor Suppressor in Human Cancers by YONGMIN LIU, BORCHERT, Gregory L, DONALD, Steven P, DIWAN, Bhalchandra A, ANVER, Miriam, PHANG, James M

“…Tumor metabolism and bioenergetics have become important topics for cancer research and are promising targets for anticancer therapy. Although glucose serves…”
Get full text

Arsenic Exposure Transforms Human Epithelial Stem/Progenitor Cells into a Cancer Stem-like Phenotype by Tokar, Erik J., Diwan, Bhalchandra A., Waalkes, Michael P.

“…Background: Inorganic arsenic is a ubiquitous environmental carcinogen affecting millions of people worldwide. Evolving theory predicts that normal stem cells…”
Get full text

Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability by Hsu, Lewis L., Champion, Hunter C., Campbell-Lee, Sally A., Bivalacqua, Trinity J., Manci, Elizabeth A., Diwan, Bhalchandra A., Schimel, Daniel M., Cochard, Audrey E., Wang, Xunde, Schechter, Alan N., Noguchi, Constance T., Gladwin, Mark T.

“…Pulmonary hypertension is a highly prevalent complication of sickle cell disease and is a strong risk factor for early mortality. However, the pathophysiologic…”
Get full text

Carcinogenic effects of "whole-life" exposure to inorganic arsenic in CD1 mice by Tokar, Erik J, Diwan, Bhalchandra A, Ward, Jerrold M, Delker, Don A, Waalkes, Michael P

“…In a previously developed mouse model, arsenic exposure in utero induces tumors at multiple sites in the offspring as adults, often duplicating human targets…”
Get full text

Arsenic-induced malignant transformation of human keratinocytes: Involvement of Nrf2 by Pi, Jingbo, Diwan, Bhalchandra A., Sun, Yang, Liu, Jie, Qu, Wei, He, Yuying, Styblo, Miroslav, Waalkes, Michael P.

“…Arsenic is a well-known human skin carcinogen but the underlying mechanisms of carcinogenesis are unclear. Transcription factor Nrf2-mediated antioxidant…”
Get full text

Transplacental arsenic carcinogenesis in mice by Waalkes, Michael P., Liu, Jie, Diwan, Bhalchandra A.

“…Our work has focused on the carcinogenic effects of in utero arsenic exposure in mice. Our data show that a short period of maternal exposure to inorganic…”
Get full text

Cadmium Malignantly Transforms Normal Human Breast Epithelial Cells into a Basal-like Phenotype by Benbrahim-Tallaa, Lamia, Tokar, Erik J., Diwan, Bhalchandra A., Dill, Anna L., Coppin, Jean-François, Waalkes, Michael P.

“…Background: Breast cancer has recently been linked to cadmium exposure. Although not uniformly supported, it is hypothesized that cadmium acts as a…”
Get full text

Aberrant DNA methylation and gene expression in livers of newborn mice transplacentally exposed to a hepatocarcinogenic dose of inorganic arsenic by Xie, Yaxiong, Liu, Jie, Benbrahim-Tallaa, Lamia, Ward, Jerry M, Logsdon, Daniel, Diwan, Bhalchandra A, Waalkes, Michael P

“…Abstract Our prior work showed that brief exposure of pregnant C3H mice to inorganic arsenic-induced hepatocellular carcinoma (HCC) formation in adult male…”
Get full text

Renal, hepatic, pulmonary and adrenal tumors induced by prenatal inorganic arsenic followed by dimethylarsinic acid in adulthood in CD1 mice by Tokar, Erik J., Diwan, Bhalchandra A., Waalkes, Michael P.

“…► Arsenicals produced renal cancer in mice, in accord with human data on arsenic and kidney cancer. ► Fetal arsenic-induced liver cancer response was greatly…”
Get full text

Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice by Waalkes, Michael P, Ward, Jerrold M, Liu, Jie, Diwan, Bhalchandra A

“…Arsenic is a known human carcinogen, but development of rodent models of inorganic arsenic carcinogenesis has been problematic. Since gestation is often a…”
Get full text

Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis by Chen, Hua, Li, ShuanFang, Liu, Jie, Diwan, Bhalchandra A., Barrett, J. Carl, Waalkes, Michael P.

“…Inorganic arsenic is a human carcinogen that can target the liver, but its carcinogenic mechanisms are still unknown. Global DNA hypomethylation occurs during…”
Get full text

Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics by Waalkes, Michael P, Liu, Jie, Germolec, Dori R, Trempus, Carol S, Cannon, Ronald E, Tokar, Erik J, Tennant, Raymond W, Ward, Jerrold M, Diwan, Bhalchandra A

“…Arsenic is a carcinogen with transplacental activity that can affect human skin stem cell population dynamics in vitro by blocking exit into differentiation…”
Get full text

Tumors and proliferative lesions in adult offspring after maternal exposure to methylarsonous acid during gestation in CD1 mice by Tokar, Erik J., Diwan, Bhalchandra A., Thomas, David J., Waalkes, Michael P.

“…Developmental exposure to inorganic arsenic is carcinogenic in humans and mice, and adult offspring of mice exposed to inorganic arsenic can develop tumors of…”
Get full text

Early life inorganic lead exposure induces testicular teratoma and renal and urinary bladder preneoplasia in adult metallothionein-knockout mice but not in wild type mice by Tokar, Erik J, Diwan, Bhalchandra A, Waalkes, Michael P

“…Abstract Inorganic lead compounds are carcinogenic in animals and have carcinogenic potential in humans. In mice, lead (Pb) is a transplacental carcinogen in…”
Get full text

Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifen by Waalkes, Michael P., Liu, Jie, Ward, Jerrold M., Diwan, Bhalchandra A.

“…Pregnant CD1 mice received 85 ppm arsenite in the drinking water from gestation day 8 to 18, groups ( n  =  35) of male offspring were subsequently injected on…”
Get full text

Urogenital carcinogenesis in female CD1 mice induced by in utero arsenic exposure is exacerbated by postnatal diethylstilbestrol treatment by WAALKES, Michael P, JIE LIU, WARD, Jerrold M, POWELL, Douglas A, DIWAN, Bhalchandra A

“…Transplacental inorganic arsenic carcinogenicity, together with postnatal exposure to diethylstilbestrol or tamoxifen, was studied. Pregnant CD1 mice received…”
Get full text

Induction of tumors of the liver, lung, ovary and adrenal in adult mice after brief maternal gestational exposure to inorganic arsenic: promotional effects of postnatal phorbol ester exposure on hepatic and pulmonary, but not dermal cancers by Waalkes, Michael P., Ward, Jerrold M., Diwan, Bhalchandra A.

“…Arsenic is a recognized human carcinogen and development of rodent models remains a critically important research objective. Since gestation can be a period of…”
Get full text

Critical Windows of Exposure for Children's Health: Cancer in Human Epidemiological Studies and Neoplasms in Experimental Animal Models by Anderson, Lucy M., Diwan, Bhalchandra A., Fear, Nicola T., Roman, Eve

“…In humans, cancer may be caused by genetics and environmental exposures; however, in the majority of instances the identification of the critical time window…”
Get full text

Association of Arsenic-Induced Malignant Transformation with DNA Hypomethylation and Aberrant Gene Expression by Zhao, Christopher Q., Young, Matthew R., Diwan, Bhalchandra A., Coogan, Timothy P., Waalkes, Michael P.

“…Inorganic arsenic, a human carcinogen, is enzymatically methylated for detoxication, consuming S-adenosyl-methionine (SAM) in the process. The fact that DNA…”
Get full text