Search Results - "Ditzel, Lars"

Crystal Structure of the Thermosome, the Archaeal Chaperonin and Homolog of CCT by Ditzel, Lars, Löwe, Jan, Stock, Daniela, Stetter, Karl-Otto, Huber, Harald, Huber, Robert, Steinbacher, Stefan

“…We have determined to 2.6 Å resolution the crystal structure of the thermosome, the archaeal group II chaperonin from T. acidophilum. The hexadecameric homolog…”
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Crystal Structure of Heat Shock Locus V (HslV) from Escherichia coli by Bochtler, Matthias, Ditzel, Lars, Groll, Michael, Huber, Robert

“…Heat shock locus V (HslV; also called ClpQ) is the proteolytic core of the ATP-dependent protease HslVU in Escherichia coli. It has sequence similarity with…”
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Conformational constraints for protein self-cleavage in the proteasome by Ditzel, Lars, Huber, Robert, Mann, Karlheinz, Heinemeyer, Wolfgang, Wolf, Dieter H, Groll, Michael

“…The proteasome is the central enzyme of protein degradation in the cytosol and the nucleus. It is involved in the removal of abnormal, misfolded or incorrectly…”
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Review: Nucleotide Binding to the Thermoplasma Thermosome: Implications for the Functional Cycle of Group II Chaperonins by Steinbacher, Stefan, Ditzel, Lars

“…Structuralinformation on group II chaperonins became available during recent years from electron microscopy and X-ray crystallography. Three conformational…”
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Structure of 20S proteasome from yeast at 2.4 angstrom resolution by Groll, M, Ditzel, L, Lowe, J, Stock, D, Bochtler, M, Bartunik, H.D, Huber, R

“…The crystal structure of the 20S proteasome from the yeast Saccharomyces cerevisiae shows that its 28 protein subunits are arranged as an (alpha 1 . . .alpha…”
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THE PROTEASOME by Bochtler, Matthias, Ditzel, Lars, Groll, Michael, Hartmann, Claudia, Huber, Robert

“…Proteasomes are large multisubunit proteases that are found in the cytosol, both free and attached to the endoplasmic reticulum, and in the nucleus of…”
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Structure of 20S proteasome from yeast at 2.4 Å resolution by GROLL, M, DITZEL, L, LÖWE, J, STOCK, D, BOCHTLER, M, BARTUNIK, H. D, HUBER, R

“…The crystal structure of the 20S proteasome from the yeast Saccharomyces cerevisiae shows that its 28 protein subunits are arranged as an (alpha1...alpha7,…”
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Structure of 20S proteasome from yeast at 2.4Å resolution by Groll, Michael, Ditzel, Lars, Löwe, Jan, Stock, Daniela, Bochtler, Matthias, Bartunik, Hans D, Huber, Robert

“…The crystal structure of the 20S proteasome from the yeast Saccharomyces cerevisiae shows that its 28 protein subunits are arranged as an (alpha1...alpha7,…”
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Hypomethylation of the Xmrk oncogene promoter in melanoma cells of Xiphophorus by Altschmied, J, Ditzel, L, Schartl, M

“…Melanoma formation in Xiphophorus is caused by the tissue-specific overexpression of the Xmrk oncogene. This gene arose by a non-homologous recombination event…”
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Structural investigation of proteasome inhibition by Ditzel, L, Stock, D, Löwe, J

“…The novel proteolytic mechanism of the 20S proteasome from T. acidophilum has been investigated by X-ray crystallography using small-molecule inhibitors and…”
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Synthesis, kinetic characterization and X-ray analysis of peptide aldehydes as inhibitors of the 20S proteasomes from Thermoplasma acidophilum and Saccharomyces cerevisiae by Escherich, A, Ditzel, L, Musiol, H J, Groll, M, Huber, R, Moroder, L

“…A comparative kinetic characterization of the peptide aldehydes Ac-Leu-Leu-X-H [X = Trp, Tyr and Tyr(tBu)] and Z-Gly-Pro-Gly-Gly-Leu-Leu-Nle-H as inhibitors of…”
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Bifunctional inhibitors of the trypsin-like activity of eukaryotic proteasomes by Loidl, Günther, Groll, Michael, Musiol, Hans-Jürgen, Ditzel, Lars, Huber, Robert, Moroder, Luis

“…The 20S proteasome is a multicatalytic protease complex that exhibits trypsin-like, chymotrypsin-like and post-glutamyl-peptide hydrolytic activities…”
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