Search Results - "Dittrich, C"

Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study by Harrison, Stephen A., Alkhouri, Naim, Davison, Beth A., Sanyal, Arun, Edwards, Christopher, Colca, Jerry R., Lee, Bo Hyun, Loomba, Rohit, Cusi, Kenneth, Kolterman, Orville, Cotter, Gad, Dittrich, Howard C.

“…[Display omitted] •A new insulin sensitizer can be dosed to full effect without dose-limiting side effects.•MSDC-0602K improved glucose metabolism and liver…”
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Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials by Vergote, Ignace, Coens, Corneel, Nankivell, Matthew, Kristensen, Gunnar B, Parmar, Mahesh K B, Jayson, Gordon C, Swart, Ann Marie, Verheijen, René, McCluggage, W Glenn, Perren, Tim, Panici, Pierluigi Benedetti, Kenter, Gemma, Casado, Antonio, Mendiola, Cesar, Stuart, Gavin, Reed, Nick S, Kehoe, Sean, Tropé G., Claes, Dobbs, Stephen, Essapen, Sharadah, Hoskins, P., Van Baal, M., Twigg, Jeremy, Van Der Burg, Maria E.L., Godfrey, Keith, Lacave, Angel J., Redman, Charles, Lotocki, R., Olaitan, Adeola, Mosgaard, B., Rustin, G., Persic, Mojca, Hogg, Martin, Van Der Velden, J., Ledermann, J., Peter Sykes, Peter Sykes, Hird, Vicky, Sandvei R., R., Cruickshank, D.J., Ottevanger, P.B., Pearson, Sheila, Hall, Marcia, Bessette, P., Gerdin, E., Lopes, Tito, Fish, Andrew, Van Eygen, K., Floquet, A., Tholander, B., Gul, N., Gornall, Robert, Luesley, David, Symonds, Paul, Poole, David, McNeish, Ian, Hocking, Mark, Sammaraie, Al, Speiser, P., Leblanc, E., De Oliveira, C.F., Grimshaw, R., Zola, P., Parkin, David, Lamb, Martin, Gillespie, Alan, Hamid, Abdel, Ahmed, Ahmed, Perez, David, Skailes, Geraldine, Jones, Rachel, Leeson, Simon, Elit, L., Gotlieb, W., Crosse, Barbara, Ridley, Paul, Head, Anthony, Nieto, Joaquin, Awwad, Saif, Brinkmann, Dirk, Eustace, Damian, Katsaros, D., Popadiuk, C., Redman, C., Chan, S., Marth, C., Lankaster, Kate, Indrajit, Fernando, Quigley, Mary, Adeyemi, Olu, McNally, Orla, Tristam, Amanda, Lee, Martin, Counsell, R., Gleeson, N., Papadopoulos, A., Maggino, T., Ghatage, P., Vermorken, J.B., Petru, E, Amant, F.

“…Individual patient data from two randomised trials comparing neoadjuvant chemotherapy with upfront debulking surgery in advanced tubo-ovarian cancer were…”
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Linking discoveries, mechanisms, and technologies to develop a clearer perspective on plant long noncoding RNAs by Palos, Kyle, Yu, Li’ang, Railey, Caylyn E, Nelson Dittrich, Anna C, Nelson, Andrew D L

“…Abstract Long noncoding RNAs (lncRNAs) are a large and diverse class of genes in eukaryotic genomes that contribute to a variety of regulatory processes…”
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Diuretic response in acute heart failure: clinical characteristics and prognostic significance by Valente, Mattia A. E., Voors, Adriaan A., Damman, Kevin, Van Veldhuisen, Dirk J., Massie, Barrie M., O'Connor, Christopher M., Metra, Marco, Ponikowski, Piotr, Teerlink, John R., Cotter, Gad, Davison, Beth, Cleland, John G.F., Givertz, Michael M., Bloomfield, Daniel M., Fiuzat, Mona, Dittrich, Howard C., Hillege, Hans L.

“…Aim Diminished diuretic response is common in patients with acute heart failure, although a clinically useful definition is lacking. Our aim was to investigate…”
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Comparative analyses suggest a link between mRNA splicing, stability, and RNA covalent modifications in flowering plants by Palos, Kyle, Nelson Dittrich, Anna C, Lyons, Eric H, Gregory, Brian D, Nelson, Andrew D L

“…In recent years, covalent modifications on RNA nucleotides have emerged as pivotal moieties influencing the structure, function, and regulatory processes of…”
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Identification and functional annotation of long intergenic non-coding RNAs in Brassicaceae by Palos, Kyle, Nelson Dittrich, Anna C, Yu, Li'ang, Brock, Jordan R, Railey, Caylyn E, Wu, Hsin-Yen Larry, Sokolowska, Ewelina, Skirycz, Aleksandra, Hsu, Polly Yingshan, Gregory, Brian D, Lyons, Eric, Beilstein, Mark A, Nelson, Andrew D L

“…Long intergenic noncoding RNAs (lincRNAs) are a large yet enigmatic class of eukaryotic transcripts that can have critical biological functions. The wealth of…”
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Evolution in an ancient detoxification pathway is coupled with a transition to herbivory in the drosophilidae by Gloss, Andrew D, Vassão, Daniel G, Hailey, Alexander L, Nelson Dittrich, Anna C, Schramm, Katharina, Reichelt, Michael, Rast, Timothy J, Weichsel, Andrzej, Cravens, Matthew G, Gershenzon, Jonathan, Montfort, William R, Whiteman, Noah K

“…Chemically defended plant tissues present formidable barriers to herbivores. Although mechanisms to resist plant defenses have been identified in ancient…”
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Fluid overload in acute heart failure - Re-distribution and other mechanisms beyond fluid accumulation by Cotter, Gad, Metra, Marco, Milo-Cotter, Olga, Dittrich, Howard C., Gheorghiade, Mihai

“…Although fluid overload is one of the most prominent features of acute heart failure (AHF), its mechanism remains challenging, due to the lack of consistent…”
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86 INVITED Novel Designs and Alternate Endpoints for New Drug Studies by Dittrich, C

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Heritable plant phenotypes track light and herbivory levels at fine spatial scales by Humphrey, P. T., Gloss, A. D., Frazier, J., Nelson–Dittrich, A. C., Faries, S., Whiteman, N. K.

“…Organismal phenotypes often co-vary with environmental variables across broad geographic ranges. Less is known about the extent to which phenotypes match local…”
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Identification and Characterization of the Heat-Induced Plastidial Stress Granules Reveal New Insight Into Arabidopsis Stress Response by Chodasiewicz, Monika, Sokolowska, Ewelina Maria, Nelson-Dittrich, Anna C., Masiuk, Aleksandra, Beltran, Juan Camilo Moreno, Nelson, Andrew D. L., Skirycz, Aleksandra

“…Plants exhibit different physiological and molecular responses to adverse changes in their environment. One such molecular response is the sequestration of…”
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Patient journey after admission for acute heart failure: length of stay, 30-day readmission and 90-day mortality by Davison, Beth A., Metra, Marco, Senger, Stefanie, Edwards, Christopher, Milo, Olga, Bloomfield, Daniel M., Cleland, John G., Dittrich, Howard C., Givertz, Michael M., O'Connor, Christopher M., Massie, Barry M., Ponikowski, Piotr, Teerlink, John R., Voors, Adriaan A., Cotter, Gad

“…Aims The course of patients following admission for acute heart failure (AHF) is of major importance to patients and healthcare providers. We examined…”
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An ESMO-EORTC position paper on the EU clinical trials regulation and EMA's transparency policy: making European research more competitive again by Dittrich, C., Negrouk, A., Casali, P.G.

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Plasma biomarkers to predict or rule out early post‐discharge events after hospitalization for acute heart failure by Demissei, Biniyam G., Postmus, Douwe, Cleland, John G., O'Connor, Christopher M., Metra, Marco, Ponikowski, Piotr, Teerlink, John R., Cotter, Gad, Davison, Beth A., Givertz, Michael M., Bloomfield, Daniel M., van Veldhuisen, Dirk J., Dittrich, Howard C., Hillege, Hans L., Voors, Adriaan A.

“…Aim Improved prediction of early post‐discharge death or rehospitalization after admission for acute heart failure is a major unmet need. We evaluated the…”
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Reply to the letter to the editor ‘Integrating communication as a core skill in the global curriculum for medical oncology’ by Horlait et al by Dittrich, C., Stiefel, F., Kiss, A., Dizon, D.S.

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A randomised phase II trial of the Polo-like kinase inhibitor BI 2536 in chemo-naïve patients with unresectable exocrine adenocarcinoma of the pancreas – a study within the Central European Society Anticancer Drug Research (CESAR) collaborative network by Mross, K, Dittrich, C, Aulitzky, W E, Strumberg, D, Schutte, J, Schmid, R M, Hollerbach, S, Merger, M, Munzert, G, Fleischer, F, Scheulen, M E

“…Background: BI 2536, a novel Polo-like kinase 1 inhibitor, was assessed in patients with unresectable advanced exocrine adenocarcinoma of the pancreas…”
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Maintenance of genetic diversity through plant–herbivore interactions by Gloss, Andrew D, Nelson Dittrich, Anna C, Goldman-Huertas, Benjamin, Whiteman, Noah K

“…•Genomic studies reveal variation at genes mediating plant–herbivore interactions.•Theory suggests spatially varying selection (SVS) maintains this…”
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An open-label, randomized phase II study of adecatumumab, a fully human anti-EpCAM antibody, as monotherapy in patients with metastatic breast cancer by Schmidt, M., Scheulen, M.E., Dittrich, C., Obrist, P., Marschner, N., Dirix, L., Schmidt, M., Rüttinger, D., Schuler, M., Reinhardt, C., Awada, A.

“…High-level expression of epithelial cell adhesion molecule (EpCAM) is associated with unfavorable prognosis in breast cancer. This study was designed to…”
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Biomarker Profiles of Acute Heart Failure Patients With a Mid-Range Ejection Fraction by Tromp, Jasper, MD, Khan, Mohsin A.F., PhD, Mentz, Robert J., MD, O’Connor, Christopher M., MD, Metra, Marco, MD, Dittrich, Howard C., MD, Ponikowski, Piotr, MD, Teerlink, John R., MD, Cotter, Gad, MD, Davison, Beth, PhD, Cleland, John G.F., MD, Givertz, Michael M., MD, Bloomfield, Daniel M., MD, van Veldhuisen, Dirk J., MD, PhD, Hillege, Hans L., PhD, Voors, Adriaan A., MD, PhD, van der Meer, Peter, MD, PhD

“…Abstract Objectives In this study, the authors used biomarker profiles to characterize differences between patients with acute heart failure with a midrange…”
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Quantitative Profiling of the Effects of Vanoxerine on Human Cardiac Ion Channels and its Application to Cardiac Risk by Obejero-Paz, Carlos A., Bruening-Wright, Andrew, Kramer, James, Hawryluk, Peter, Tatalovic, Milos, Dittrich, Howard C., Brown, Arthur M.

“…Vanoxerine has been in clinical trials for Parkinsonism, depression and cocaine addiction but lacked efficacy. Although a potent blocker of hERG, it produced…”
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