Search Results - "Dite, Toby A."

AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965 by Dite, Toby A., Langendorf, Christopher G., Hoque, Ashfaqul, Galic, Sandra, Rebello, Richard J., Ovens, Ashley J., Lindqvist, Lisa M., Ngoei, Kevin R.W., Ling, Naomi X.Y., Furic, Luc, Kemp, Bruce E., Scott, John W., Oakhill, Jonathan S.

“…Inhibition of the metabolic regulator AMP-activated protein kinase (AMPK) is increasingly being investigated for its therapeutic potential in diseases where…”
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CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins by Langendorf, Christopher G., O'Brien, Matthew T., Ngoei, Kevin R.W., McAloon, Luke M., Dhagat, Urmi, Hoque, Ashfaqul, Ling, Naomi X.Y., Dite, Toby A., Galic, Sandra, Loh, Kim, Parker, Michael W., Oakhill, Jonathan S., Kemp, Bruce E., Scott, John W.

“…The calcium-calmodulin–dependent protein kinase kinase-2 (CaMKK2) is a key regulator of cellular and whole-body energy metabolism. It is known to be activated…”
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Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone by Vrahnas, Christina, Blank, Martha, Dite, Toby A., Tatarczuch, Liliana, Ansari, Niloufar, Crimeen-Irwin, Blessing, Nguyen, Huynh, Forwood, Mark R., Hu, Yifang, Ikegame, Mika, Bambery, Keith R., Petibois, Cyril, Mackie, Eleanor J., Tobin, Mark J., Smyth, Gordon K., Oakhill, Jonathan S., Martin, T. John, Sims, Natalie A.

“…Mineralized bone forms when collagen-containing osteoid accrues mineral crystals. This is initiated rapidly (primary mineralization), and continues slowly…”
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The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs by Dite, Toby A., Ling, Naomi X. Y., Scott, John W., Hoque, Ashfaqul, Galic, Sandra, Parker, Benjamin L., Ngoei, Kevin R. W., Langendorf, Christopher G., O’Brien, Matthew T., Kundu, Mondira, Viollet, Benoit, Steinberg, Gregory R., Sakamoto, Kei, Kemp, Bruce E., Oakhill, Jonathan S.

“…AMP-activated protein kinase (AMPK) is a metabolic stress-sensing enzyme responsible for maintaining cellular energy homeostasis. Activation of AMPK by…”
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Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling by Roy, Michael J., Surudoi, Minglyanna G., Kropp, Ashleigh, Hou, Jianmei, Dai, Weiwen, Hardy, Joshua M., Liang, Lung-Yu, Cotton, Thomas R., Lechtenberg, Bernhard C., Dite, Toby A., Ma, Xiuquan, Daly, Roger J., Patel, Onisha, Lucet, Isabelle S.

“…PEAK pseudokinases regulate cell migration, invasion and proliferation by recruiting key signaling proteins to the cytoskeleton. Despite lacking catalytic…”
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Cryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin by Sarson-Lawrence, Kaiseal T. G., Hardy, Joshua M., Iaria, Josephine, Stockwell, Dina, Behrens, Kira, Saiyed, Tamanna, Tan, Cyrus, Jebeli, Leila, Scott, Nichollas E., Dite, Toby A., Nicola, Nicos A., Leis, Andrew P., Babon, Jeffrey J., Kershaw, Nadia J.

“…Thrombopoietin (Tpo) is the primary regulator of megakaryocyte and platelet numbers and is required for haematopoetic stem cell maintenance. Tpo functions by…”
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mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress by Ling, Naomi X. Y., Kaczmarek, Adrian, Hoque, Ashfaqul, Davie, Elizabeth, Ngoei, Kevin R. W., Morrison, Kaitlin R., Smiles, William J., Forte, Gabriella M., Wang, Tingting, Lie, Shervi, Dite, Toby A., Langendorf, Christopher G., Scott, John W., Oakhill, Jonathan S., Petersen, Janni

“…Highly conserved signalling pathways controlled by mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK) are central to cellular…”
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Caspase-2 protects against ferroptotic cell death by Dawar, Swati, Benitez, Mariana C., Lim, Yoon, Dite, Toby A., Yousef, Jumana M., Thio, Niko, Garciaz, Sylvain, Jackson, Thomas D., Milne, Julia V., Dagley, Laura F., Phillips, Wayne A., Kumar, Sharad, Clemons, Nicholas J.

“…Caspase-2, one of the most evolutionarily conserved members of the caspase family, is an important regulator of the cellular response to oxidative stress…”
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Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism by Hoffman, Nolan J., Whitfield, Jamie, Janzen, Natalie R., Belhaj, Mehdi R., Galic, Sandra, Murray-Segal, Lisa, Smiles, William J., Ling, Naomi X.Y., Dite, Toby A., Scott, John W., Oakhill, Jonathan S., Brink, Robert, Kemp, Bruce E., Hawley, John A.

“…Glycogen is a major energy reserve in liver and skeletal muscle. The master metabolic regulator AMP-activated protein kinase (AMPK) associates with glycogen…”
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Author Correction: Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone by Vrahnas, Christina, Blank, Martha, Dite, Toby A., Tatarczuch, Liliana, Ansari, Niloufar, Crimeen-Irwin, Blessing, Nguyen, Huynh, Forwood, Mark R., Hu, Yifang, Ikegame, Mika, Bambery, Keith R., Petibois, Cyril, Mackie, Eleanor J., Tobin, Mark J., Smyth, Gordon K., Oakhill, Jonathan S., Martin, T. John, Sims, Natalie A.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion by Lindqvist, Lisa M., Frank, Daniel, McArthur, Kate, Dite, Toby A., Lazarou, Michael, Oakhill, Jonathan S., Kile, Benjamin T., Vaux, David L.

“…Cells undergoing Bax/Bak-mediated apoptosis exhibit signs of autophagy, but how it is activated and its significance is unknown. By directly activating Bax/Bak…”
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Transient Expression of AMPK Heterotrimer Complexes in Mammalian Cells by Oakhill, Jonathan S, Scott, John W, Dite, Toby A

“…Regulation of AMP-activated protein kinase (AMPK) signalling is complex and involves contributions from adenine nucleotides, co-/posttranslational…”
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Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling by Scott, John W., Ling, Naomi, Issa, Samah M.A., Dite, Toby A., O’Brien, Matthew T., Chen, Zhi-Ping, Galic, Sandra, Langendorf, Christopher G., Steinberg, Gregory R., Kemp, Bruce E., Oakhill, Jonathan S.

“…The AMP-activated protein kinase (AMPK) is a metabolic stress-sensing αβγ heterotrimer responsible for energy homeostasis, making it a therapeutic target for…”
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Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation by O’Brien, Matthew T., Oakhill, Jonathan S., Ling, Naomi X. Y., Langendorf, Christopher G., Hoque, Ashfaqul, Dite, Toby A., Means, Anthony R., Kemp, Bruce E., Scott, John W.

“…The Ca 2+ -calmodulin dependent protein kinase kinase-2 (CaMKK2) is a key regulator of neuronal function and whole-body energy metabolism. Elevated CaMKK2…”
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Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder by Scott, John W., Park, Elizabeth, Rodriguiz, Ramona M., Oakhill, Jonathan S., Issa, Samah M. A., O’Brien, Matthew T., Dite, Toby A., Langendorf, Christopher G., Wetsel, William C., Means, Anthony R., Kemp, Bruce E.

“…Mutations that reduce expression or give rise to a Thr85Ser (T85S) mutation of Ca 2+ -CaM-dependent protein kinase kinase-2 (CaMKK2) have been implicated in…”
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Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release by Scott, John W., Galic, Sandra, Graham, Kate L., Foitzik, Richard, Ling, Naomi X.Y., Dite, Toby A., Issa, Samah M.A., Langendorf, Chris G., Weng, Qing Ping, Thomas, Helen E., Kay, Thomas W., Birnberg, Neal C., Steinberg, Gregory R., Kemp, Bruce E., Oakhill, Jonathan S.

“…The AMP-activated protein kinase (AMPK) is a metabolic stress-sensing αβγ heterotrimer responsible for energy homeostasis. Pharmacological inhibition of AMPK…”
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Structural mapping of the PEAK pseudokinase interactome identifies 14-3-3 as a molecular switch regulating PEAK3/Crk signalling by Roy, Michael J., Surudoi, Minglyanna, Kropp, Ashleigh, Hou, Jianmei, Dai, Weiwen, Hardy, Joshua M., Liang, Lung-Yu, Cotton, Thomas R., Lechtenberg, Bernhard C., Dite, Toby A., Ma, Xiuquan, Daly, Roger J., Patel, Onisha, Lucet, Isabelle S.

“…Abstract only…”
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Impact of Genetic Variation on Human CaMKK2 Regulation by Ca 2+ -Calmodulin and Multisite Phosphorylation by O'Brien, Matthew T, Oakhill, Jonathan S, Ling, Naomi X Y, Langendorf, Christopher G, Hoque, Ashfaqul, Dite, Toby A, Means, Anthony R, Kemp, Bruce E, Scott, John W

“…The Ca -calmodulin dependent protein kinase kinase-2 (CaMKK2) is a key regulator of neuronal function and whole-body energy metabolism. Elevated CaMKK2…”
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