Search Results - "Distler, Alfiya"

Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis by Chakraborty, Debomita, Šumová, Barbora, Mallano, Tatjana, Chen, Chih-Wei, Distler, Alfiya, Bergmann, Christina, Ludolph, Ingo, Horch, Raymund E., Gelse, Kolja, Ramming, Andreas, Distler, Oliver, Schett, Georg, Šenolt, Ladislav, Distler, Jörg H. W.

“…Signal transducer and activator of transcription 3 (STAT3) is phosphorylated by various kinases, several of which have been implicated in aberrant fibroblast…”
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Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis by Huang, Jingang, Beyer, Christian, Palumbo-Zerr, Katrin, Zhang, Yun, Ramming, Andreas, Distler, Alfiya, Gelse, Kolja, Distler, Oliver, Schett, Georg, Wollin, Lutz, Distler, Jörg H W

“…Nintedanib is a tyrosine kinase inhibitor that has recently been shown to slow disease progression in idiopathic pulmonary fibrosis in two replicate phase III…”
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Inactivation of autophagy ameliorates glucocorticoid-induced and ovariectomy-induced bone loss by Lin, Neng-Yu, Chen, Chih-Wei, Kagwiria, Rosebeth, Liang, Ruifang, Beyer, Christian, Distler, Alfiya, Luther, Julia, Engelke, Klaus, Schett, Georg, Distler, Jörg Hw

“…Autophagy has recently been shown to regulate osteoclast activity and osteoclast differentiation. Here, we aim to investigate the impact of autophagy…”
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Signature of circulating microRNAs in osteoarthritis by Beyer, Christian, Zampetaki, Anna, Lin, Neng-Yu, Kleyer, Arnd, Perricone, Carlo, Iagnocco, Annamaria, Distler, Alfiya, Langley, Sarah R, Gelse, Kolja, Sesselmann, Stefan, Lorenzini, Rolando, Niemeier, Andreas, Swoboda, Bernd, Distler, Jörg H W, Santer, Peter, Egger, Georg, Willeit, Johann, Mayr, Manuel, Schett, Georg, Kiechl, Stefan

“…Osteoarthritis is the most common form of arthritis and a major socioeconomic burden. Our study is the first to explore the association between serum microRNA…”
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Author Correction: Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis by Chakraborty, Debomita, Šumová, Barbora, Mallano, Tatjana, Chen, Chih-Wei, Distler, Alfiya, Bergmann, Christina, Ludolph, Ingo, Horch, Raymund E., Gelse, Kolja, Ramming, Andreas, Distler, Oliver, Schett, Georg, Šenolt, Ladislav, Distler, Jörg H. W.

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Stimulators of soluble guanylate cyclase (sGC) inhibit experimental skin fibrosis of different aetiologies by Dees, Clara, Beyer, Christian, Distler, Alfiya, Soare, Alina, Zhang, Yun, Palumbo-Zerr, Katrin, Distler, Oliver, Schett, Georg, Sandner, Peter, Distler, Jörg H W

“…Stimulators of the soluble guanylate cyclase (sGC) have recently been shown to inhibit transforming growth factor-β signalling. Here, we aimed to demonstrate…”
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Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis by Krämer, Marlene, Dees, Clara, Huang, Jingang, Schlottmann, Inga, Palumbo-Zerr, Katrin, Zerr, Pawel, Gelse, Kolja, Beyer, Christian, Distler, Alfiya, Marquez, Victor E, Distler, Oliver, Schett, Georg, Distler, Jörg H W

“…Epigenetic modifications such as DNA methylation and histone acetylation have been implicated in the pathogenesis of systemic sclerosis. However, histone…”
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Combined inhibition of morphogen pathways demonstrates additive antifibrotic effects and improved tolerability by Distler, Alfiya, Lang, Veronika, Del Vecchio, Tina, Huang, Jingang, Zhang, Yun, Beyer, Christian, Lin, Neng-Yu, Palumbo-Zerr, Katrin, Distler, Oliver, Schett, Georg, Distler, Jörg Hw

“…The morphogen pathways Hedgehog, Wnt and Notch are attractive targets for antifibrotic therapies in systemic sclerosis. Interference with stem cell…”
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Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease by Zerr, Pawel, Palumbo-Zerr, Katrin, Distler, Alfiya, Tomcik, Michal, Vollath, Stefan, Munoz, Luis E., Beyer, Christian, Dees, Clara, Egberts, Friederike, Tinazzi, Ilaria, Del Galdo, Francesco, Distler, Oliver, Schett, Georg, Spriewald, Bernd M., Distler, Jörg H.W.

“…Chronic graft-versus-host disease (cGVHD) is a prognosis limiting complication of allogeneic stem cell transplantation. The molecular mechanisms underlying…”
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Cardiomyopathy in Murine Models of Systemic Sclerosis by Venalis, Paulius, Kumánovics, Gábor, Schulze‐Koops, Hendrik, Distler, Alfiya, Dees, Clara, Zerr, Pawel, Palumbo‐Zerr, Katrin, Czirják, László, Mackevic, Zygmunt, Lundberg, Ingrid E., Distler, Oliver, Schett, Georg, Distler, Jörg H. W.

“…Objective Cardiomyopathy has emerged as a leading cause of death in patients with systemic sclerosis (SSc). However, the pathogenesis of SSc‐related…”
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Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis by Palumbo-Zerr, Katrin, Zerr, Pawel, Distler, Alfiya, Fliehr, Judith, Mancuso, Rossella, Huang, Jingang, Mielenz, Dirk, Tomcik, Michal, Fürnrohr, Barbara G, Scholtysek, Carina, Dees, Clara, Beyer, Christian, Krönke, Gerhard, Metzger, Daniel, Distler, Oliver, Schett, Georg, Distler, Jörg H W

“…NR4A1 is shown to be an endogenous inhibitor of TGF-β-induced fibrosis and represents a therapeutic target for this condition. Mesenchymal responses are an…”
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The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis by Dees, Clara, Schlottmann, Inga, Funke, Robin, Distler, Alfiya, Palumbo-Zerr, Katrin, Zerr, Pawel, Lin, Neng-Yu, Beyer, Christian, Distler, Oliver, Schett, Georg, Distler, Jörg H W

“…Activated Wnt signalling with decreased expression of endogenous inhibitors has recently been characterised as a central pathomechanism in systemic sclerosis…”
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Vitamin D receptor regulates TGF-β signalling in systemic sclerosis by Zerr, Pawel, Vollath, Stefan, Palumbo-Zerr, Katrin, Tomcik, Michal, Huang, Jingang, Distler, Alfiya, Beyer, Christian, Dees, Clara, Gela, Kolja, Distler, Oliver, Schett, Georg, Distler, Jörg H W

“…Vitamin D receptor (VDR) is a member of the nuclear receptor superfamily. Its ligand, 1,25-(OH)2D, is a metabolically active hormone derived from vitamin D3…”
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Autophagy regulates TNFα-mediated joint destruction in experimental arthritis by Lin, Neng-Yu, Beyer, Christian, Giessl, Andreas, Kireva, Trayana, Scholtysek, Carina, Uderhardt, Stefan, Munoz, Luis Enrique, Dees, Clara, Distler, Alfiya, Wirtz, Stefan, Krönke, Gerhard, Spencer, Brian, Distler, Oliver, Schett, Georg, Distler, Jörg H W

“…Autophagy is a homeostatic process to recycle dispensable and damaged cell organelles. Dysregulation of autophagic pathways has recently been implicated in the…”
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Vascular endothelial growth factor aggravates fibrosis and vasculopathy in experimental models of systemic sclerosis by Maurer, Britta, Distler, Alfiya, Suliman, Yossra A, Gay, Renate E, Michel, Beat A, Gay, Steffen, Distler, Jörg H W, Distler, Oliver

“…High levels of vascular endothelial growth factor (VEGF), a key angiogenic factor, are present in patients with systemic sclerosis (SSc), but its role in the…”
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JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment by Zhang, Yun, Liang, Ruifang, Chen, Chih-Wei, Mallano, Tatjana, Dees, Clara, Distler, Alfiya, Reich, Adam, Bergmann, Christina, Ramming, Andreas, Gelse, Kolja, Mielenz, Dirk, Distler, Oliver, Schett, Georg, Distler, Jörg H W

“…Janus kinase 2 (JAK2) has recently been described as a novel downstream mediator of the pro-fibrotic effects of transforming growth factor-β. Although JAK2…”
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Translational engagement of lysophosphatidic acid receptor 1 in skin fibrosis: from dermal fibroblasts of patients with scleroderma to tight skin 1 mouse by Ledein, Laetitia, Léger, Bertrand, Dees, Clara, Beyer, Christian, Distler, Alfiya, Vettori, Serena, Boukaiba, Rachid, Bidouard, Jean Pierre, Schaefer, Matthias, Pernerstorfer, Josef, Ruetten, Hartmut, Jagerschmidt, Alexandre, Janiak, Philip, Distler, Jörg H.W., Distler, Oliver, Illiano, Stéphane

“…Background and Purpose Genetic deletion and pharmacological studies suggest a role for lysophosphatidic acid (LPA1) receptor in fibrosis. We investigated the…”
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Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling by Beyer, Christian, Zenzmaier, Christoph, Palumbo-Zerr, Katrin, Mancuso, Rossella, Distler, Alfiya, Dees, Clara, Zerr, Pawel, Huang, Jingang, Maier, Christiane, Pachowsky, Milena L, Friebe, Andreas, Sandner, Peter, Distler, Oliver, Schett, Georg, Berger, Peter, Distler, Jörg H W

“…We have previously described the antifibrotic role of the soluble guanylate cyclase (sGC). The mode of action, however, remained elusive. In the present study,…”
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Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis by Beyer, Christian, Reichert, Helena, Akan, Hümeyra, Mallano, Tatjana, Schramm, Amelie, Dees, Clara, Palumbo-Zerr, Katrin, Lin, Neng Yu, Distler, Alfiya, Gelse, Kolja, Varga, John, Distler, Oliver, Schett, Georg, Distler, Jörg H W

“…Fibrosis is a major socioeconomic burden, but effective antifibrotic therapies are not available in the clinical routine. There is growing evidence for a…”
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Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling by Distler, Alfiya, Deloch, Lisa, Huang, Jingang, Dees, Clara, Lin, Neng-Yu, Palumbo-Zerr, Katrin, Beyer, Christian, Weidemann, Alexander, Distler, Oliver, Schett, Georg, Distler, Jörg H W

“…Canonical Wnt signalling has recently emerged as a key mediator of fibroblast activation and tissue fibrosis in systemic sclerosis. Here, we investigated…”
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