Search Results - "Distefano, Gianfranco"

Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1 by Distefano, Gianfranco, Boca, Manila, Rowe, Isaline, Wodarczyk, Claas, Ma, Li, Piontek, Klaus B., Germino, Gregory G., Pandolfi, Pier Paolo, Boletta, Alessandra

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Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression by Clerici, Sara, Podrini, Christine, Stefanoni, Davide, Distefano, Gianfranco, Cassina, Laura, Steidl, Maria Elena, Tronci, Laura, Canu, Tamara, Chiaravalli, Marco, Spies, Daniel, Bell, Thomas A, Costa, Ana SH, Esposito, Antonio, D’Alessandro, Angelo, Frezza, Christian, Bachi, Angela, Boletta, Alessandra

“…Polycystic kidney disease (PKD) is a genetic disorder characterized by bilateral cyst formation. We showed that PKD cells and kidneys display metabolic…”
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Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways by Podrini, Christine, Rowe, Isaline, Pagliarini, Roberto, Costa, Ana S. H., Chiaravalli, Marco, Di Meo, Ivano, Kim, Hyunho, Distefano, Gianfranco, Tiranti, Valeria, Qian, Feng, di Bernardo, Diego, Frezza, Christian, Boletta, Alessandra

“…Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by loss-of-function mutations in PKD1 or PKD2 . Increased glycolysis is a…”
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Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase/Akt signaling pathway by BOCA, Manila, DISTEFANO, Gianfranco, FENG QIAN, BHUNIA, Anil K, GERMINO, Gregory G, BOLETTA, Alessandra

“…Polycystin-1 (PC-1), the PKD1 gene product, is a large receptor whose expression in renal epithelial cells results in resistance to apoptosis and…”
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Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals by Wodarczyk, Claas, Distefano, Gianfranco, Rowe, Isaline, Gaetani, Massimiliano, Bricoli, Barbara, Muorah, Mordi, Spitaleri, Andrea, Mannella, Valeria, Ricchiuto, Piero, Pema, Monika, Castelli, Maddalena, Casanova, Ariel E, Mollica, Luca, Banzi, Manuela, Boca, Manila, Antignac, Corinne, Saunier, Sophie, Musco, Giovanna, Boletta, Alessandra

“…Mutations in PKD1, the gene encoding for the receptor Polycystin-1 (PC-1), cause autosomal dominant polycystic kidney disease (ADPKD). The cytoplasmic…”
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Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration by Castelli, Maddalena, De Pascalis, Chiara, Distefano, Gianfranco, Ducano, Nadia, Oldani, Amanda, Lanzetti, Letizia, Boletta, Alessandra

“…Polycystin-1 (PC-1) is a large plasma membrane receptor, encoded by the PKD1 gene, which is mutated in most cases of Autosomal Dominant Polycystic Kidney…”
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Polycystin-1 Regulates Actomyosin Contraction and the Cellular Response to Extracellular Stiffness by Nigro, Elisa Agnese, Distefano, Gianfranco, Chiaravalli, Marco, Matafora, Vittoria, Castelli, Maddalena, Pesenti Gritti, Angela, Bachi, Angela, Boletta, Alessandra

“…Polycystin-1 (PC-1) and 2 (PC-2) are the products of the PKD1 and PKD2 genes, which are mutated in Autosomal Dominant Polycystic Kidney Disease (ADPKD). They…”
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Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis by Castelli, Maddalena, Boca, Manila, Chiaravalli, Marco, Ramalingam, Harini, Rowe, Isaline, Distefano, Gianfranco, Carroll, Thomas, Boletta, Alessandra

“…Several organs, including the lungs and kidneys, are formed by epithelial tubes whose proper morphogenesis ensures correct function. This is best exemplified…”
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Polycystin-1 Induces Cell Migration by Regulating Phosphatidylinositol 3-kinase-dependent Cytoskeletal Rearrangements and GSK3β-dependent Cell–Cell Mechanical Adhesion by Boca, Manila, D'Amato, Lisa, Distefano, Gianfranco, Polishchuk, Roman S., Germino, Gregory G., Boletta, Alessandra

“…Polycystin-1 (PC-1) is a large plasma-membrane receptor encoded by the PKD1 gene mutated in autosomal dominant polycystic kidney disease (ADPKD). Although the…”
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Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease by Molteni, Raffaella, Biavasco, Riccardo, Stefanoni, Davide, Nemkov, Travis, Domínguez-Andrés, Jorge, Arts, Rob J., Merelli, Ivan, Mazza, Davide, Zambrano, Samuel, Panigada, Maddalena, Cantoni, Eleonora, Tengesdal, Isak W., Maksud, Philippe, Piras, Francesco, Cesana, Daniela, Cassina, Laura, Distefano, Gianfranco, Loffreda, Alessia, Gnani, Daniela, De Luca, Giacomo, Tomelleri, Alessandro, Campochiaro, Corrado, Joosten, Leo A.B., Dinarello, Charles A., Kajaste-Rudnitski, Anna, Haroche, Julien, Cardaci, Simone, Cenci, Simone, Dagna, Lorenzo, Doglioni, Claudio, Ferrarini, Marina, Ferrero, Elisabetta, Boletta, Alessandra, D'Alessandro, Angelo, Montini, Eugenio, Netea, Mihai G., Cavalli, Giulio

“…Trained immunity (TI) is a proinflammatory program induced in monocyte/macrophages upon sensing of specific pathogens and is characterized by immunometabolic…”
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Primary cilia sense glutamine availability and respond via asparagine synthetase by Steidl, Maria Elena, Nigro, Elisa A., Nielsen, Anne Kallehauge, Pagliarini, Roberto, Cassina, Laura, Lampis, Matteo, Podrini, Christine, Chiaravalli, Marco, Mannella, Valeria, Distefano, Gianfranco, Yang, Ming, Aslanyan, Mariam, Musco, Giovanna, Roepman, Ronald, Frezza, Christian, Boletta, Alessandra

“…Depriving cells of nutrients triggers an energetic crisis, which is resolved by metabolic rewiring and organelle reorganization. Primary cilia are…”
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Genetic engineering of ?2,6-sialyltransferase in recombinant CHO cells and its effects on the sialylation of recombinant interferon-? by Monaco, Lucia, Marc, Annie, Eon-Duval, Alex, Acerbis, Giulia, Distefano, Gianfranco, Lamotte, Damien, Engasser, Jean-Marc, Soria, Marco, Jenkins, Nigel

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Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion by Boca, Manila, D'Amato, Lisa, Distefano, Gianfranco, Polishchuk, Roman S, Germino, Gregory G, Boletta, Alessandra

“…Polycystin-1 (PC-1) is a large plasma-membrane receptor encoded by the PKD1 gene mutated in autosomal dominant polycystic kidney disease (ADPKD). Although the…”
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A new Chinese hamster ovary cell line expressing α2,6-sialyltransferase used as universal host for the production of human-like sialylated recombinant glycoproteins by Bragonzi, Alessandra, Distefano, Gianfranco, Buckberry, Lorraine D, Acerbis, Giulia, Foglieni, Chiara, Lamotte, Damien, Campi, Gabriele, Marc, Annie, Soria, Marco R, Jenkins, Nigel, Monaco, Lucia

“…Chinese hamster ovary (CHO) cells are widely employed to produce glycosylated recombinant proteins. Our group as well as others have demonstrated that the…”
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Genetic engineering of α2,6-sialyltransferase in recombinant CHO cells and its effects on the sialylation of recombinant interferon-γ by Monaco, L, Marc, A, Eon-Duval, A, Acerbis, G, Distefano, G, Lamotte, D, Engasser, J M, Soria, M, Jenkins, N

“…The CHO cell line has achieved considerable commercial importance as a vehicle for the production of human therapeutic proteins, but is known to lack a…”
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"HepG2/erythroid/brain" type glucose transporter (GLUT1) is highly expressed in human epidermis: keratinocyte differentiation affects GLUT1 levels in reconstituted epidermis by Gherzi, R, Melioli, G, de Luca, M, D'Agostino, A, Distefano, G, Guastella, M, D'Anna, F, Franzi, A T, Cancedda, R

“…In mature animals, the "HepG2/erythroid/brain" glucose transporter isoform (GLUT1) appears to be expressed at the highest levels at blood tissue barriers;…”
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