Search Results - "Diskin, Ciana"

Metabolic Modulation in Macrophage Effector Function by Diskin, Ciana, Pålsson-McDermott, Eva M

“…Traditionally cellular respiration or metabolism has been viewed as catabolic and anabolic pathways generating energy and biosynthetic precursors required for…”
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Caspase-11 promotes allergic airway inflammation by Zasłona, Zbigniew, Flis, Ewelina, Wilk, Mieszko M., Carroll, Richard G., Palsson-McDermott, Eva M., Hughes, Mark M., Diskin, Ciana, Banahan, Kathy, Ryan, Dylan G., Hooftman, Alexander, Misiak, Alicja, Kearney, Jay, Lochnit, Gunter, Bertrams, Wilhelm, Greulich, Timm, Schmeck, Bernd, McElvaney, Oliver J., Mills, Kingston H. G., Lavelle, Ed C., Wygrecka, Małgorzata, Creagh, Emma M., O’Neill, Luke A. J.

“…Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E 2 (PGE 2 ) inhibits…”
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Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance by Fazakerley, Daniel J, Chaudhuri, Rima, Yang, Pengyi, Maghzal, Ghassan J, Thomas, Kristen C, Krycer, James R, Humphrey, Sean J, Parker, Benjamin L, Fisher-Wellman, Kelsey H, Meoli, Christopher C, Hoffman, Nolan J, Diskin, Ciana, Burchfield, James G, Cowley, Mark J, Kaplan, Warren, Modrusan, Zora, Kolumam, Ganesh, Yang, Jean Yh, Chen, Daniel L, Samocha-Bonet, Dorit, Greenfield, Jerry R, Hoehn, Kyle L, Stocker, Roland, James, David E

“…Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial…”
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Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation by Hughes, Mark M., Hooftman, Alexander, Angiari, Stefano, Tummala, Padmaja, Zaslona, Zbigniew, Runtsch, Marah C., McGettrick, Anne F., Sutton, Caroline E., Diskin, Ciana, Rooke, Melissa, Takahashi, Shuhei, Sundararaj, Srinivasan, Casarotto, Marco G., Dahlstrom, Jane E., Palsson-McDermott, Eva M., Corr, Sinead C., Mills, Kingston H.G., Preston, Roger J.S., Neamati, Nouri, Xie, Yiyue, Baell, Jonathan B., Board, Philip G., O’Neill, Luke A.J.

“…The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the…”
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A gas trapping method for high-throughput metabolic experiments by Krycer, James R, Diskin, Ciana, Nelson, Marin E, Zeng, Xiao-Yi, Fazakerley, Daniel J, James, David E

“…Research into cellular metabolism has become more high-throughput, with typical cell-culture experiments being performed in multiwell plates (microplates)…”
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4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages by Diskin, Ciana, Zotta, Alessia, Corcoran, Sarah E., Tyrrell, Victoria J., Zaslona, Zbigniew, O’Donnell, Valerie B., O’Neill, Luke A. J.

“…Abstract PGs are important proinflammatory lipid mediators, the significance of which is highlighted by the widespread and efficacious use of nonsteroidal…”
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4-Octyl Itaconate and Dimethyl Fumarate Induce Secretion of the Anti-Inflammatory Protein Annexin A1 via NRF2 by Diskin, Ciana, Day, Emily A, Henry, Órlaith C, Toller-Kawahisa, Juliana E, O'Neill, Luke A J

“…Annexin A1 is a key anti-inflammatory effector protein that is involved in the anti-inflammatory effects of glucocorticoids. 4-Octyl itaconate (4-OI), a…”
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The Trypanosome-Derived Metabolite Indole-3-Pyruvate Inhibits Prostaglandin Production in Macrophages by Targeting COX2 by Diskin, Ciana, Corcoran, Sarah E., Tyrrell, Victoria J., McGettrick, Anne F., Zaslona, Zbigniew, O’Donnell, Valerie B., Nolan, Derek P., O’Neill, Luke A. J.

“…Abstract The protozoan parasite Trypanosoma brucei is the causative agent of the neglected tropical disease human African trypanosomiasis, otherwise known as…”
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