Search Results - "Discover. Oncology"

The gold complex auranofin: new perspectives for cancer therapy by Abdalbari, Farah H., Telleria, Carlos M.

“…Advanced stages of cancer are highly associated with short overall survival in patients due to the lack of long-term treatment options following the standard…”
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Wnt/β-catenin signal transduction pathway in prostate cancer and associated drug resistance by Wang, Chunyang, Chen, Qi, Xu, Huachao

“…Globally, prostate cancer ranks second in cancer burden of the men. It occurs more frequently in black men compared to white or Asian men. Usually, high rates…”
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Acetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor development by Ling, Rui, Chen, Gong, Tang, Xiang, Liu, Na, Zhou, Yuepeng, Chen, Deyu

“…Acetyl-CoA synthetase 2 (ACSS2), an important member of the acetyl-CoA synthetase (ACSS) family, can catalyze the conversion of acetate to acetyl coenzyme A…”
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RUNX1-IT1 favors breast cancer carcinogenesis through regulation of IGF2BP1/GPX4 axis by Wang, Shengting, Wang, Yufang, Li, Qian, Zeng, Kaixuan, Li, Xiaoming, Feng, Xinghua

“…Breast cancer is the most common malignancy among women and the leading cause of cancer deaths, with complicated pathogenesis that is largely unknown. In this…”
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Prognostic significance of tumor infiltrating lymphocytes on first-line pembrolizumab efficacy in advanced non-small cell lung cancer by Kaira, Kyoichi, Yamaguchi, Ou, Kawasaki, Tomonori, Hashimoto, Kousuke, Miura, Yu, Shiono, Ayako, Mouri, Atsuto, Imai, Hisao, Kobayashi, Kunihiko, Yasuda, Masanori, Kagamu, Hiroshi

“…Aim Tumor-infiltrating lymphocytes (TILs) in the tumor and stroma are expected to accurately predict the efficacy of programmed death-1 (PD-1) blockade…”
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Exploring the role of Nrf2 signaling in glioblastoma multiforme by Awuah, Wireko Andrew, Toufik, Abdul-Rahman, Yarlagadda, Rohan, Mikhailova, Tatiana, Mehta, Aashna, Huang, Helen, Kundu, Mrinmoy, Lopes, Leilani, Benson, Sylvester, Mykola, Lyndin, Vladyslav, Sikora, Alexiou, Athanasios, Alghamdi, Badrah S., Hashem, Anwar M., Md Ashraf, Ghulam

“…Glioblastoma multiforme (GBM) is one of the most aggressive glial cell tumors in adults. Although current treatment options for GBM offer some therapeutic…”
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Thoracic SMARCA4-deficient undifferentiated tumor by Jiang, Jiapeng, Chen, Zhixin, Gong, Jiali, Han, Na, Lu, Hongyang

“…Thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a recently described smoking-related malignancy. The pathogenesis of SMARCA4-UT is the…”
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Cancer vaccines: past, present and future; a review article by Grimmett, Eddie, Al-Share, Bayan, Alkassab, Mohamad Basem, Zhou, Ryan Weng, Desai, Advait, Rahim, Mir Munir A., Woldie, Indryas

“…Immunotherapy and vaccines have revolutionized disease treatment and prevention. Vaccines against infectious diseases have been in use for several decades. In…”
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High dose isoleucine stabilizes nuclear PTEN to suppress the proliferation of lung cancer by Wang, Haiqing, Chen, Sen, Kang, Wenhui, Ding, Bojiao, Cui, Shulan, Zhou, Li, Zhang, Na, Luo, Huiying, Wang, Mingjuan, Zhang, Fan, Zhao, Zezhou, Guo, Zihu, Wang, Chao, Li, Liang, Wang, Zhengzhong, Chen, Xuetong, Wang, Yonghua

“…Purpose Cancer cells require a supply of amino acids, particularly essential amino acids such as branched-chain amino acids (BCAAs, i.e., valine, leucine, and…”
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A demonstration based on multi-omics transcriptome sequencing data revealed disulfidptosis heterogeneity within the tumor microenvironment of esophageal squamous cell carcinoma by Liu, Fuxing, Yuan, Donglan, Liu, Xia, Zhuo, Shichao, Liu, Xinyun, Sheng, Haihui, Sha, Min, Ye, Jun, Yu, Hong

“…Background It is of great concern to identify prognostic signatures for the prediction and prediction of esophageal squamous cell carcinoma (ESCC), which is…”
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Emerging roles of noncoding RNAs in human cancers by Wu, Shijie, Wu, Yiwen, Deng, Sijun, Lei, Xiaoyong, Yang, Xiaoyan

“…Studies have found that RNA encoding proteins only account for a small part of the total number, most RNA is non-coding RNA, and non-coding RNA may affect the…”
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Natural killer cell immunotherapy in glioblastoma by Hosseinalizadeh, Hamed, Habibi Roudkenar, Mehryar, Mohammadi Roushandeh, Amaneh, Kuwahara, Yoshikazu, Tomita, Kazuo, Sato, Tomoaki

“…Glioblastoma (GBM) is one of the most difficult cancers to treat because GBM has the high therapeutic resistance. Recently, immunotherapies for GBM have been…”
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Efficacy and safety of metformin plus low-dose temozolomide in patients with recurrent or refractory glioblastoma: a randomized, prospective, multicenter, double-blind, controlled, phase 2 trial (KNOG-1501 study) by Yoon, Wan-Soo, Chang, Jong Hee, Kim, Jeong Hoon, Kim, Yu Jung, Jung, Tae-Young, Yoo, Heon, Kim, Se-Hyuk, Ko, Young-Cho, Nam, Do-Hyun, Kim, Tae Min, Kim, Se Hoon, Park, Sung-Hae, Lee, Youn Soo, Yim, Hyeon Woo, Hong, Yong-Kil, Yang, Seung Ho

“…Purpose Glioblastoma (GBM) has a poor prognosis after standard treatment. Recently, metformin has been shown to have an antitumor effect on glioma cells. We…”
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Focal adhesion kinase inhibitor BI 853520 inhibits cell proliferation, migration and EMT process through PI3K/AKT/mTOR signaling pathway in ovarian cancer by Li, Hong, Gao, Yizhi, Ren, Chenchen

“…Focal adhesion kinase (FAK) activation has been reported to be associated with cell progression and metastasis in a wide variety of cancer cells. Target…”
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Awareness of intratumoral bacteria and their potential application in cancer treatment by Liang, Yin, Li, Qiyan, Liu, Yulin, Guo, Yajie, Li, Qingjiao

“…Hitherto, the recognition of the microbiota role in tumorigenesis and clinical studies mostly focused on the intestinal flora. In contrast to the gut…”
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The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics by Zhang, Sijia, Zong, Yan, Chen, Leichong, Li, Qianwen, Li, Zhenyu, Meng, Rui

“…More than 60 years ago, disulfiram (DSF) was employed for the management of alcohol addiction. This promising cancer therapeutic agent inhibits proliferation,…”
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Roles of exosomes as drug delivery systems in cancer immunotherapy: a mini-review by Fang, Zhen, Ding, Yixuan, Xue, Zhigang, Li, Peijuan, Li, Jia, Li, Fei

“…Exosomes can be released by a variety of cells and participate in intercellular communication in many physiological processes in the body. They can be used as…”
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Exploration of biomarkers for the diagnosis, treatment and prognosis of cervical cancer: a review by Arip, Masita, Tan, Lee Fang, Jayaraj, Rama, Abdullah, Maha, Rajagopal, Mogana, Selvaraja, Malarvili

“…As the fourth most diagnosed cancer, cervical cancer (CC) is one of the major causes of cancer-related mortality affecting females globally, particularly when…”
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O-GlcNAcylation links oncogenic signals and cancer epigenetics by Sun, Lidong, Lv, Suli, Song, Tanjing

“…Prevalent dysregulation of epigenetic modifications plays a pivotal role in cancer. Targeting epigenetic abnormality is a new strategy for cancer therapy…”
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Impact of sarcopenia on the prognosis and treatment of lung cancer: an umbrella review by Lin, Ting-Yu, Chen, Yen-Fu, Wu, Wei-Ting, Han, Der-Sheng, Tsai, I.-Chen, Chang, Ke-Vin, Özçakar, Levent

“…Background Lung cancer is the leading cause of cancer-related mortality worldwide. Sarcopenia, defined as the loss of muscle mass and function, is known to…”
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