Search Results - "Dirnagl, Ulrich"

Preregistration of exploratory research: Learning from the golden age of discovery by Dirnagl, Ulrich

“…Preregistration of study protocols and, in particular, Registered Reports are novel publishing formats that are currently gaining substantial traction. Besides…”
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Pathobiology of injury after stroke: the neurovascular unit and beyond by Dirnagl, Ulrich

“…Throughout the history of research on stroke pathophysiology, focus has shifted from purely vascular concepts to the insight that a complex interplay of…”
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Bench to bedside: the quest for quality in experimental stroke research by Dirnagl, Ulrich

“…Over the past decades, great progress has been made in clinical as well as experimental stroke research. Disappointingly, however, hundreds of clinical trials…”
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Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation by Chamorro, Ángel, Prof, Dirnagl, Ulrich, MD, Urra, Xabier, MD, Planas, Anna M, PhD

“…Summary Treatments for acute ischaemic stroke continue to evolve after the superior value of endovascular thrombectomy was confirmed over systemic…”
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Modeling Immunity and Inflammation in Stroke: Can Mice Be Trusted? by Dirnagl, Ulrich

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Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use by Dirnagl, Ulrich, MD, Becker, Kyra, MD, Meisel, Andreas, MD

“…Summary Neuroprotection and brain repair in patients after acute brain damage are still major unfulfilled medical needs. Pharmacological treatments are either…”
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Distinguishing between exploratory and confirmatory preclinical research will improve translation by Kimmelman, Jonathan, Mogil, Jeffrey S, Dirnagl, Ulrich

“…Preclinical researchers confront two overarching agendas related to drug development: selecting interventions amid a vast field of candidates, and producing…”
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The Hong Kong Principles for assessing researchers: Fostering research integrity by Moher, David, Bouter, Lex, Kleinert, Sabine, Glasziou, Paul, Sham, Mai Har, Barbour, Virginia, Coriat, Anne-Marie, Foeger, Nicole, Dirnagl, Ulrich

“…For knowledge to benefit research and society, it must be trustworthy. Trustworthy research is robust, rigorous, and transparent at all stages of design,…”
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The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research by Percie du Sert, Nathalie, Hurst, Viki, Ahluwalia, Amrita, Alam, Sabina, Avey, Marc T, Baker, Monya, Browne, William J, Clark, Alejandra, Cuthill, Innes C, Dirnagl, Ulrich, Emerson, Michael, Garner, Paul, Holgate, Stephen T, Howells, David W, Karp, Natasha A, Lazic, Stanley E, Lidster, Katie, MacCallum, Catriona J, Macleod, Malcolm, Pearl, Esther J, Petersen, Ole H, Rawle, Frances, Reynolds, Penny, Rooney, Kieron, Sena, Emily S, Silberberg, Shai D, Steckler, Thomas, Würbel, Hanno

“…Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in…”
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Biomedical research: increasing value, reducing waste by Macleod, Malcolm R, Michie, Susan, Roberts, Ian, Dirnagl, Ulrich, Chalmers, Iain, Ioannidis, John P A, Salman, Rustam Al-Shahi, Chan, An-Wen, Glasziou, Paul

“…Global biomedical and public health research involves billions of dollars and millions of people. Although this vast enterprise has led to substantial health…”
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The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research by Percie du Sert, Nathalie, Hurst, Viki, Ahluwalia, Amrita, Alam, Sabina, Avey, Marc T., Baker, Monya, Browne, William J., Clark, Alejandra, Cuthill, Innes C., Dirnagl, Ulrich, Emerson, Michael, Garner, Paul, Holgate, Stephen T., Howells, David W., Karp, Natasha A., Lazic, Stanley E., Lidster, Katie, MacCallum, Catriona J., Macleod, Malcolm, Pearl, Esther J., Petersen, Ole H., Rawle, Frances, Reynolds, Penny, Rooney, Kieron, Sena, Emily S., Silberberg, Shai D., Steckler, Thomas, Würbel, Hanno

“…Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in…”
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Stroke induced Sarcopenia: Muscle wasting and disability after stroke by Scherbakov, Nadja, von Haehling, Stephan, Anker, Stefan D, Dirnagl, Ulrich, Doehner, Wolfram

“…Abstract Stroke is the second leading cause of death and the leading cause of disability in Western countries. More than 60% of patients remain disabled, 50%…”
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Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain by Fernández-Klett, Francisco, Offenhauser, Nikolas, Dirnagl, Ulrich, Priller, Josef, Lindauer, Ute, Raichle, Marcus E.

“…Modern functional imaging techniques of the brain measure local hemodynamic responses evoked by neuronal activity. Capillary pericytes recently were suggested…”
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International, Multicenter Randomized Preclinical Trials in Translational Stroke Research: It's Time to Act by Dirnagl, Ulrich, Fisher, Marc

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Improving the trustworthiness, usefulness, and ethics of biomedical research through an innovative and comprehensive institutional initiative by Strech, Daniel, Weissgerber, Tracey, Dirnagl, Ulrich

“…The reproducibility crisis triggered worldwide initiatives to improve rigor, reproducibility, and transparency in biomedical research. There are many examples…”
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The ARRIVE guidelines 2.0: updated guidelines for reporting animal research by Percie du Sert, Nathalie, Hurst, Viki, Ahluwalia, Amrita, Alam, Sabina, Avey, Marc T., Baker, Monya, Browne, William J., Clark, Alejandra, Cuthill, Innes C., Dirnagl, Ulrich, Emerson, Michael, Garner, Paul, Holgate, Stephen T., Howells, David W., Karp, Natasha A., Lazic, Stanley E., Lidster, Katie, MacCallum, Catriona J., Macleod, Malcolm, Pearl, Esther J., Petersen, Ole H., Rawle, Frances, Reynolds, Penny, Rooney, Kieron, Sena, Emily S., Silberberg, Shai D., Steckler, Thomas, Würbel, Hanno

“…Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in…”
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Improving target assessment in biomedical research: the GOT-IT recommendations by Emmerich, Christoph H., Gamboa, Lorena Martinez, Hofmann, Martine C. J., Bonin-Andresen, Marc, Arbach, Olga, Schendel, Pascal, Gerlach, Björn, Hempel, Katja, Bespalov, Anton, Dirnagl, Ulrich, Parnham, Michael J.

“…Academic research plays a key role in identifying new drug targets, including understanding target biology and links between targets and disease states. To…”
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Incorporating equity, diversity, and inclusiveness into the Hong Kong Principles by Moher, David, Bouter, Lex, Foeger, Nicole, Dirnagl, Ulrich

“…In this response to Labib and Evans, authors of the Hong Kong Principles look forward to collaborating with those from the broad research integrity community…”
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Improving preclinical studies through replications by Drude, Natascha Ingrid, Martinez Gamboa, Lorena, Danziger, Meggie, Dirnagl, Ulrich, Toelch, Ulf

“…The purpose of preclinical research is to inform the development of novel diagnostics or therapeutics, and the results of experiments on animal models of…”
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The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research by Percie du Sert, Nathalie, Hurst, Viki, Ahluwalia, Amrita, Alam, Sabina, Avey, Marc T., Baker, Monya, Browne, William J., Clark, Alejandra, Cuthill, Innes C., Dirnagl, Ulrich, Emerson, Michael, Garner, Paul, Holgate, Stephen T., Howells, David W., Karp, Natasha A., Lazic, Stanley E., Lidster, Katie, MacCallum, Catriona J., Macleod, Malcolm, Pearl, Esther J., Petersen, Ole H., Rawle, Frances, Reynolds, Penny, Rooney, Kieron, Sena, Emily S., Silberberg, Shai D., Steckler, Thomas, Würbel, Hanno

“…Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in…”
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