Search Results - "Dirks, Peter"

Brain Tumor Stem Cells: Bringing Order to the Chaos of Brain Cancer by Dirks, Peter B

“…Brain tumors are generally incurable cancers. Work from a number of laboratories strongly suggests that they are organized as a hierarchy based on a subset of…”
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Making a commitment: neurons refuse cancer’s advances by Dirks, Peter B.

“…The cell of origin for malignant brain tumors remains uncertain, but de-differentiation from mature cells in the CNS has always been considered a strong…”
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Functional Enhancers Shape Extrachromosomal Oncogene Amplifications by Morton, Andrew R., Dogan-Artun, Nergiz, Faber, Zachary J., MacLeod, Graham, Bartels, Cynthia F., Piazza, Megan S., Allan, Kevin C., Mack, Stephen C., Wang, Xiuxing, Gimple, Ryan C., Wu, Qiulian, Rubin, Brian P., Shetty, Shashirekha, Angers, Stephane, Dirks, Peter B., Sallari, Richard C., Lupien, Mathieu, Rich, Jeremy N., Scacheri, Peter C.

“…Non-coding regions amplified beyond oncogene borders have largely been ignored. Using a computational approach, we find signatures of significant…”
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GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer by Wu, Qin, ba-alawi, Wail, Deblois, Genevieve, Cruickshank, Jennifer, Duan, Shili, Lima-Fernandes, Evelyne, Haight, Jillian, Tonekaboni, Seyed Ali Madani, Fortier, Anne-Marie, Kuasne, Hellen, McKee, Trevor D., Mahmoud, Hassan, Kushida, Michelle, Cameron, Sarina, Dogan-Artun, Nergiz, Chen, WenJun, Nie, Yan, Zhang, Lan Xin, Vellanki, Ravi N., Zhou, Stanley, Prinos, Panagiotis, Wouters, Bradly G., Dirks, Peter B., Done, Susan J., Park, Morag, Cescon, David W., Haibe-Kains, Benjamin, Lupien, Mathieu, Arrowsmith, Cheryl H.

“…Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the development of resistance to chemotherapy affecting over 30% of patients. New…”
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Survival and functional outcomes of molecularly defined childhood posterior fossa ependymoma: Cure at a cost by Zapotocky, Michal, Beera, Kiran, Adamski, Jenny, Laperierre, Normand, Guger, Sharon, Janzen, Laura, Lassaletta, Alvaro, Figueiredo Nobre, Liana, Bartels, Ute, Tabori, Uri, Hawkins, Cynthia, Urbach, Stacey, Tsang, Derek S., Dirks, Peter B., Taylor, Michael D., Bouffet, Eric, Mabbott, Donald J., Ramaswamy, Vijay

“…Background Posterior fossa ependymoma (PFE) comprises 2 groups, PF group A (PFA) and PF group B (PFB), with stark differences in outcome. However, to the…”
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A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression by Chen, Xin, Wanggou, Siyi, Bodalia, Ankur, Zhu, Min, Dong, Weifan, Fan, Jerry J., Yin, Wen Chi, Min, Hyun-Kee, Hu, Malini, Draghici, Diana, Dou, Wenkun, Li, Feng, Coutinho, Fiona J., Whetstone, Heather, Kushida, Michelle M., Dirks, Peter B., Song, Yuanquan, Hui, Chi-chung, Sun, Yu, Wang, Lu-Yang, Li, Xuejun, Huang, Xi

“…Alteration of tissue mechanical properties is a physical hallmark of solid tumors including gliomas. How tumor cells sense and regulate tissue mechanics is…”
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Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity by Meyer, Mona, Reimand, Jüri, Lan, Xiaoyang, Head, Renee, Zhu, Xueming, Kushida, Michelle, Bayani, Jane, Pressey, Jessica C., Lionel, Anath C., Clarke, Ian D., Cusimano, Michael, Squire, Jeremy A., Scherer, Stephen W., Bernstein, Mark, Woodin, Melanie A., Bader, Gary D., Dirks, Peter B.

“…Glioblastoma (GBM) is a cancer comprised of morphologically, genetically, and phenotypically diverse cells. However, an understanding of the functional…”
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Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy by Lan, Xiaoyang, Jörg, David J., Cavalli, Florence M. G., Richards, Laura M., Nguyen, Long V., Vanner, Robert J., Guilhamon, Paul, Lee, Lilian, Kushida, Michelle M., Pellacani, Davide, Park, Nicole I., Coutinho, Fiona J., Whetstone, Heather, Selvadurai, Hayden J., Che, Clare, Luu, Betty, Carles, Annaick, Moksa, Michelle, Rastegar, Naghmeh, Head, Renee, Dolma, Sonam, Prinos, Panagiotis, Cusimano, Michael D., Das, Sunit, Bernstein, Mark, Arrowsmith, Cheryl H., Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Gallo, Marco, Lupien, Mathieu, Pugh, Trevor J., Taylor, Michael D., Hirst, Martin, Eaves, Connie J., Simons, Benjamin D., Dirks, Peter B.

“…Human glioblastomas harbour a subpopulation of glioblastoma stem cells that drive tumorigenesis. However, the origin of intratumoural functional heterogeneity…”
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High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities by Hart, Traver, Chandrashekhar, Megha, Aregger, Michael, Steinhart, Zachary, Brown, Kevin R., MacLeod, Graham, Mis, Monika, Zimmermann, Michal, Fradet-Turcotte, Amelie, Sun, Song, Mero, Patricia, Dirks, Peter, Sidhu, Sachdev, Roth, Frederick P., Rissland, Olivia S., Durocher, Daniel, Angers, Stephane, Moffat, Jason

“…The ability to perturb genes in human cells is crucial for elucidating gene function and holds great potential for finding therapeutic targets for diseases…”
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The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants by Pajtler, Kristian W., Mack, Stephen C., Ramaswamy, Vijay, Smith, Christian A., Witt, Hendrik, Smith, Amy, Hansford, Jordan R., von Hoff, Katja, Wright, Karen D., Hwang, Eugene, Frappaz, Didier, Kanemura, Yonehiro, Massimino, Maura, Faure-Conter, Cécile, Modena, Piergiorgio, Tabori, Uri, Warren, Katherine E., Holland, Eric C., Ichimura, Koichi, Giangaspero, Felice, Castel, David, von Deimling, Andreas, Kool, Marcel, Dirks, Peter B., Grundy, Richard G., Foreman, Nicholas K., Gajjar, Amar, Korshunov, Andrey, Finlay, Jonathan, Gilbertson, Richard J., Ellison, David W., Aldape, Kenneth D., Merchant, Thomas E., Bouffet, Eric, Pfister, Stefan M., Taylor, Michael D.

“…Multiple independent genomic profiling efforts have recently identified clinically and molecularly distinct subgroups of ependymoma arising from all three…”
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Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells by MacLeod, Graham, Bozek, Danielle A., Rajakulendran, Nishani, Monteiro, Vernon, Ahmadi, Moloud, Steinhart, Zachary, Kushida, Michelle M., Yu, Helen, Coutinho, Fiona J., Cavalli, Florence M.G., Restall, Ian, Hao, Xiaoguang, Hart, Traver, Luchman, H. Artee, Weiss, Samuel, Dirks, Peter B., Angers, Stephane

“…Glioblastoma therapies have remained elusive due to limitations in understanding mechanisms of growth and survival of the tumorigenic population. Using…”
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Foramen magnum stenosis in a 5-month-old boy with achondroplasia by Malhotra, Armaan K, Parker, Whitney, Dirks, Peter B

“…Malhotra et al discuss the case study of a 5-month-old boy with short stature and macrocephaly. His delivery had been normal, although his parents had noticed…”
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Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells by Dolma, Sonam, Selvadurai, Hayden J., Lan, Xiaoyang, Lee, Lilian, Kushida, Michelle, Voisin, Veronique, Whetstone, Heather, So, Milly, Aviv, Tzvi, Park, Nicole, Zhu, Xueming, Xu, ChangJiang, Head, Renee, Rowland, Katherine J., Bernstein, Mark, Clarke, Ian D., Bader, Gary, Harrington, Lea, Brumell, John H., Tyers, Mike, Dirks, Peter B.

“…Glioblastomas (GBM) grow in a rich neurochemical milieu, but the impact of neurochemicals on GBM growth is largely unexplored. We interrogated 680…”
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Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma by Vanner, Robert J., Remke, Marc, Gallo, Marco, Selvadurai, Hayden J., Coutinho, Fiona, Lee, Lilian, Kushida, Michelle, Head, Renee, Morrissy, Sorana, Zhu, Xueming, Aviv, Tzvi, Voisin, Veronique, Clarke, Ian D., Li, Yisu, Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Jones, Steven J.M., Marra, Marco A., Malkin, David, Northcott, Paul A., Kool, Marcel, Pfister, Stefan M., Bader, Gary, Hochedlinger, Konrad, Korshunov, Andrey, Taylor, Michael D., Dirks, Peter B.

“…Functional heterogeneity within tumors presents a significant therapeutic challenge. Here we show that quiescent, therapy-resistant Sox2+ cells propagate sonic…”
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Sténose du foramen magnum chez un garçon de 5 mois atteint d’achondroplasie by Malhotra, Armaan K, Parker, Whitney, Dirks, Peter B

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Tumour-initiating cells: challenges and opportunities for anticancer drug discovery by Zhou, Bin-Bing S, Grindley, Justin C, Zhang, Haiying, Damelin, Marc, Geles, Kenneth G, Dirks, Peter B

“…Key Points The experimental demonstration of tumour-initiating cells (popularly known as cancer stem cells) in several human tumours in recent years supports…”
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Cancer Stem cells and brain tumours by Dirks, Peter B

“…Stem cells are increasingly implicated in maintaining certain cancers. Studies of an intractable type of brain tumour provide hints as to why such cells may…”
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Roadmap for the Emerging Field of Cancer Neuroscience by Monje, Michelle, Borniger, Jeremy C., D’Silva, Nisha J., Deneen, Benjamin, Dirks, Peter B., Fattahi, Faranak, Frenette, Paul S., Garzia, Livia, Gutmann, David H., Hanahan, Douglas, Hervey-Jumper, Shawn L., Hondermarck, Hubert, Hurov, Jonathan B., Kepecs, Adam, Knox, Sarah M., Lloyd, Alison C., Magnon, Claire, Saloman, Jami L., Segal, Rosalind A., Sloan, Erica K., Sun, Xin, Taylor, Michael D., Tracey, Kevin J., Trotman, Lloyd C., Tuveson, David A., Wang, Timothy C., White, Ruth A., Winkler, Frank

“…Mounting evidence indicates that the nervous system plays a central role in cancer pathogenesis. In turn, cancers and cancer therapies can alter nervous system…”
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BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma by Mistry, Matthew, Zhukova, Nataliya, Merico, Daniele, Rakopoulos, Patricia, Krishnatry, Rahul, Shago, Mary, Stavropoulos, James, Alon, Noa, Pole, Jason D, Ray, Peter N, Navickiene, Vilma, Mangerel, Joshua, Remke, Marc, Buczkowicz, Pawel, Ramaswamy, Vijay, Guerreiro Stucklin, Ana, Li, Martin, Young, Edwin J, Zhang, Cindy, Castelo-Branco, Pedro, Bakry, Doua, Laughlin, Suzanne, Shlien, Adam, Chan, Jennifer, Ligon, Keith L, Rutka, James T, Dirks, Peter B, Taylor, Michael D, Greenberg, Mark, Malkin, David, Huang, Annie, Bouffet, Eric, Hawkins, Cynthia E, Tabori, Uri

“…To uncover the genetic events leading to transformation of pediatric low-grade glioma (PLGG) to secondary high-grade glioma (sHGG). We retrospectively…”
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Intertumoral Heterogeneity within Medulloblastoma Subgroups by Cavalli, Florence M.G., Remke, Marc, Rampasek, Ladislav, Peacock, John, Shih, David J.H., Luu, Betty, Garzia, Livia, Torchia, Jonathon, Nor, Carolina, Morrissy, A. Sorana, Agnihotri, Sameer, Thompson, Yuan Yao, Kuzan-Fischer, Claudia M., Farooq, Hamza, Isaev, Keren, Daniels, Craig, Cho, Byung-Kyu, Kim, Seung-Ki, Wang, Kyu-Chang, Lee, Ji Yeoun, Grajkowska, Wieslawa A., Perek-Polnik, Marta, Vasiljevic, Alexandre, Faure-Conter, Cecile, Jouvet, Anne, Giannini, Caterina, Nageswara Rao, Amulya A., Li, Kay Ka Wai, Ng, Ho-Keung, Eberhart, Charles G., Pollack, Ian F., Hamilton, Ronald L., Gillespie, G. Yancey, Olson, James M., Leary, Sarah, Weiss, William A., Lach, Boleslaw, Chambless, Lola B., Thompson, Reid C., Cooper, Michael K., Vibhakar, Rajeev, Hauser, Peter, van Veelen, Marie-Lise C., Kros, Johan M., French, Pim J., Ra, Young Shin, Kumabe, Toshihiro, López-Aguilar, Enrique, Zitterbart, Karel, Sterba, Jaroslav, Finocchiaro, Gaetano, Massimino, Maura, Van Meir, Erwin G., Osuka, Satoru, Shofuda, Tomoko, Klekner, Almos, Zollo, Massimo, Leonard, Jeffrey R., Rubin, Joshua B., Jabado, Nada, Albrecht, Steffen, Mora, Jaume, Van Meter, Timothy E., Jung, Shin, Moore, Andrew S., Hallahan, Andrew R., Chan, Jennifer A., Tirapelli, Daniela P.C., Carlotti, Carlos G., Fouladi, Maryam, Pimentel, José, Faria, Claudia C., Saad, Ali G., Massimi, Luca, Liau, Linda M., Wheeler, Helen, Nakamura, Hideo, Elbabaa, Samer K., Perezpeña-Diazconti, Mario, Chico Ponce de León, Fernando, Robinson, Shenandoah, Zapotocky, Michal, Lassaletta, Alvaro, Huang, Annie, Hawkins, Cynthia E., Tabori, Uri, Bouffet, Eric, Bartels, Ute, Dirks, Peter B., Rutka, James T., Bader, Gary D., Reimand, Jüri, Goldenberg, Anna, Ramaswamy, Vijay, Taylor, Michael D.

“…While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network…”
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