Search Results - "Dirk Schmidt-Arras"

Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes by Choudhary, Chunaram, Olsen, Jesper V., Brandts, Christian, Cox, Jürgen, Reddy, Pavankumar N.G., Böhmer, Frank D., Gerke, Volker, Schmidt-Arras, Dirk-E., Berdel, Wolfgang E., Müller-Tidow, Carsten, Mann, Matthias, Serve, Hubert

“…Inappropriate activation of oncogenic kinases at intracellular locations is frequently observed in human cancers, but its effects on global signaling are…”
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IL-6 pathway in the liver: From physiopathology to therapy by Schmidt-Arras, Dirk, Rose-John, Stefan

“…Summary Interleukin 6 (IL-6) is a pleiotropic four-helix-bundle cytokine that exerts multiple functions in the body. In the liver, IL-6 is an important inducer…”
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Tyrosine Phosphorylation Regulates Maturation of Receptor Tyrosine Kinases by Schmidt-Arras, Dirk-E., Böhmer, Annette, Markova, Boyka, Choudhary, Chunaram, Serve, Hubert, Böhmer, Frank-D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The pro- and anti-inflammatory properties of the cytokine interleukin-6 by Scheller, Jürgen, Chalaris, Athena, Schmidt-Arras, Dirk, Rose-John, Stefan

“…Interleukin-6 is a cytokine not only involved in inflammation and infection responses but also in the regulation of metabolic, regenerative, and neural…”
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ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation by Schumacher, Neele, Rose-John, Stefan, Schmidt-Arras, Dirk

“…Tumour growth is not solely driven by tumour cell-intrinsic mechanisms, but also depends on paracrine signals provided by the tumour micro-environment. These…”
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IL‐6 trans‐signaling is essential for the development of hepatocellular carcinoma in mice by Bergmann, Juri, Müller, Miryam, Baumann, Niklas, Reichert, Manuel, Heneweer, Carola, Bolik, Julia, Lücke, Karsten, Gruber, Sabine, Carambia, Antonella, Boretius, Susanne, Leuschner, Ivo, Becker, Thomas, Rabe, Björn, Herkel, Johannes, Wunderlich, F. Thomas, Mittrücker, Hans‐Willi, Rose‐John, Stefan, Schmidt‐Arras, Dirk

“…Hepatocellular carcinoma (HCC) is one of the most frequent tumors worldwide with rising incidence. The inflammatory cytokine, interleukin‐6 (IL‐6), is a…”
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Mislocalisation of Activated Receptor Tyrosine Kinases – Challenges for Cancer Therapy by Schmidt-Arras, Dirk, Böhmer, Frank-D.

“…Activating mutations in genes encoding receptor tyrosine kinases (RTKs) mediate proliferation, cell migration, and cell survival, and are therefore important…”
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A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis by Schwerd, Tobias, Twigg, Stephen R F, Aschenbrenner, Dominik, Manrique, Santiago, Miller, Kerry A, Taylor, Indira B, Capitani, Melania, McGowan, Simon J, Sweeney, Elizabeth, Weber, Astrid, Chen, Liye, Bowness, Paul, Riordan, Andrew, Cant, Andrew, Freeman, Alexandra F, Milner, Joshua D, Holland, Steven M, Frede, Natalie, Müller, Miryam, Schmidt-Arras, Dirk, Grimbacher, Bodo, Wall, Steven A, Jones, E Yvonne, Wilkie, Andrew O M, Uhlig, Holm H

“…Multiple cytokines, including interleukin 6 (IL-6), IL-11, IL-27, oncostatin M (OSM), and leukemia inhibitory factor (LIF), signal via the common GP130…”
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Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling by Rosenberg, Nofar, Van Haele, Matthias, Lanton, Tali, Brashi, Neta, Bromberg, Zohar, Adler, Hanan, Giladi, Hilla, Peled, Amnon, Goldenberg, Daniel S., Axelrod, Jonathan H., Simerzin, Alina, Chai, Chofit, Paldor, Mor, Markezana, Auerlia, Yaish, Dayana, Shemulian, Zohar, Gross, Dvora, Barnoy, Shanny, Gefen, Maytal, Amran, Osher, Claerhout, Sofie, Fernández-Vaquero, Mirian, García-Beccaria, María, Heide, Danijela, Shoshkes-Carmel, Michal, Schmidt Arras, Dirk, Elgavish, Sharona, Nevo, Yuval, Benyamini, Hadar, Tirnitz-Parker, Janina E.E., Sanchez, Aranzazu, Herrera, Blanca, Safadi, Rifaat, Kaestner, Klaus H., Rose-John, Stefan, Roskams, Tania, Heikenwalder, Mathias, Galun, Eithan

“…Primary liver cancers include hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (CCA) and combined HCC-CCA tumors (cHCC-CCA). It has been…”
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Cellular Inhibition of Protein Tyrosine Phosphatase 1B by Uncharged Thioxothiazolidinone Derivatives by Stuible, Matthew, Zhao, Liang, Aubry, Isabelle, Schmidt-Arras, Dirk, Böhmer, Frank-D., Li, Chao-Jun, Tremblay, Michel L.

“…As important regulators of cellular signal transduction, members of the protein tyrosine phosphatase (PTP) family are considered to be promising drug targets…”
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Endosomes as Signaling Platforms for IL-6 Family Cytokine Receptors by Schmidt-Arras, Dirk, Rose-John, Stefan

“…Interleukin-6 (IL-6) is the name-giving cytokine of a family of eleven members, including IL-6, CNTF, LIF, and IL-27. IL-6 was first recognized as a B-cell…”
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ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling by Schmidt, Stefanie, Schumacher, Neele, Schwarz, Jeanette, Tangermann, Simone, Kenner, Lukas, Schlederer, Michaela, Sibilia, Maria, Linder, Markus, Altendorf-Hofmann, Annelore, Knösel, Thomas, Gruber, Elisabeth S, Oberhuber, Georg, Bolik, Julia, Rehman, Ateequr, Sinha, Anupam, Lokau, Juliane, Arnold, Philipp, Cabron, Anne-Sophie, Zunke, Friederike, Becker-Pauly, Christoph, Preaudet, Adele, Nguyen, Paul, Huynh, Jennifer, Afshar-Sterle, Shoukat, Chand, Ashwini L, Westermann, Jürgen, Dempsey, Peter J, Garbers, Christoph, Schmidt-Arras, Dirk, Rosenstiel, Philip, Putoczki, Tracy, Ernst, Matthias, Rose-John, Stefan

“…Colorectal cancer is treated with antibodies blocking epidermal growth factor receptor (EGF-R), but therapeutic success is limited. EGF-R is stimulated by…”
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Regulation of Fibrotic Processes in the Liver by ADAM Proteases by Schmidt-Arras, Dirk, Rose-John, Stefan

“…Fibrosis in the liver is mainly associated with the activation of hepatic stellate cells (HSCs). Both activation and clearance of HSCs can be mediated by…”
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Targeting NLRP3 inhibits AML progression by inducing PERK/eIF2-mediated apoptosis by Luciano, Michela, Sieberer, Helene, Krenn, Peter W, Dang, Hieu-Hoa, Vetter, Julia, Neuper, Theresa, Amend, Diana, Blöchl, Constantin, Weichenberger, Christian X, Eglseer, Anna, Unger, Michael S, Andosch, Ancuela, Steiner, Philip, Neureiter, Daniel, Bauer, Renate, Hummer, Laura, Tesanovic, Suzana, Binder, Stephanie, Elmer, Dominik P, Strandt, Helen, Schaller, Susanne, Strunk, Dirk, Pleyer, Lisa, Greil, Richard, Winkler, Stephan, Hartmann, Tanja N, Schmidt-Arras, Dirk, Huber, Christian G, Aberger, Fritz, Horejs-Hoeck, Jutta

“…Acute myeloid leukemia (AML) is characterized by the abnormal proliferation of myeloid precursor cells and presents significant challenges in treatment due to…”
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Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation by Tsitsipatis, Dimitrios, Jayavelu, Ashok Kumar, Müller, Jörg P, Bauer, Reinhard, Schmidt-Arras, Dirk, Mahboobi, Siavosh, Schnöder, Tina M, Heidel, Florian, Böhmer, Frank-D

“…Fms-like tyrosine kinase 3 (FLT3) with internal tandem duplications (ITD) is a major oncoprotein in acute myeloid leukemia (AML), and confers an unfavorable…”
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Tetraspanin 8 Subfamily Members Regulate Substrate-Specificity of a Disintegrin and Metalloprotease 17 by Müller, Miryam, Saunders, Claire, Senftleben, Anke, Heidbuechel, Johannes P. W, Halwachs, Birgit, Bolik, Julia, Hedemann, Nina, Röder, Christian, Bauerschlag, Dirk, Rose-John, Stefan, Schmidt-Arras, Dirk

“…Ectodomain shedding is an irreversible process to regulate inter- and intracellular signaling. Members of the a disintegrin and metalloprotease (ADAM) family…”
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Oncogenic deletion mutants of gp130 signal from intracellular compartments by Schmidt-Arras, Dirk, Müller, Miryam, Stevanovic, Marija, Horn, Silke, Schütt, Antje, Bergmann, Juri, Wilkens, Ruven, Lickert, Annett, Rose-John, Stefan

“…Interleukin 6 (IL-6) and, hence, activation of the IL-6 receptor signalling subunit glycoprotein 130 (gp130; also known as interleukin-6 receptor subunit β,…”
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Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability by Cayla, Mathieu, Rachidi, Najma, Leclercq, Olivier, Schmidt-Arras, Dirk, Rosenqvist, Heidi, Wiese, Martin, Späth, Gerald F

“…Protozoan pathogens of the genus Leishmania have evolved unique signaling mechanisms that can sense changes in the host environment and trigger adaptive stage…”
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Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells by Fritsch, Jürgen, Frankenheim, Julia, Marischen, Lothar, Vadasz, Timea, Troeger, Anja, Rose-John, Stefan, Schmidt-Arras, Dirk, Schneider-Brachert, Wulf

“…Signaling via death receptor family members such as TNF-R1 mediates pleiotropic biological outcomes ranging from inflammation and proliferation to cell death…”
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Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality by Schmidt-Arras, Dirk, Böhmer, Sylvia-Annette, Koch, Sina, Müller, Jörg P., Blei, Lutz, Cornils, Hauke, Bauer, Reinhard, Korasikha, Sridhar, Thiede, Christian, Böhmer, Frank-D.

“…The mechanism of cell transformation by Fms-like tyrosine kinase 3 (FLT3) in acute myeloid leukemia (AML) is incompletely understood. The most prevalent…”
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