Search Results - "Dirk M. Hermann"

Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation by Hermann, Dirk M, Prof, Chopp, Michael, Prof

“…Summary Recent laboratory findings suggest that it might be possible to promote cerebral plasticity and neurological recovery after stroke by use of exogenous…”
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Hot topics in cellular neuropathology III: using CRISPR/Cas9 technology for deciphering central nervous system disease targets by Hermann, Dirk M.

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Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice by Herz, Josephine, Sabellek, Pascal, Lane, Thomas E, Gunzer, Matthias, Hermann, Dirk M, Doeppner, Thorsten R

“…BACKGROUND AND PURPOSE—Inflammation-related comorbidities contribute to stroke-induced immune responses and brain damage. We previously showed that…”
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Implications of polymorphonuclear neutrophils for ischemic stroke and intracerebral hemorrhage: Predictive value, pathophysiological consequences and utility as therapeutic target by Hermann, Dirk M., Kleinschnitz, Christoph, Gunzer, Matthias

“…Polymorphonuclear neutrophil granulocytes (PMN) orchestrate the removal of cell debris in ischemic stroke and intracerebral hemorrhage. In both pathologies,…”
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Multicellular Crosstalk Between Exosomes and the Neurovascular Unit After Cerebral Ischemia. Therapeutic Implications by Zagrean, Ana-Maria, Hermann, Dirk M, Opris, Ioan, Zagrean, Leon, Popa-Wagner, Aurel

“…Restorative strategies after stroke are focused on the remodeling of cerebral endothelial cells and brain parenchymal cells. The latter, i.e., neurons, neural…”
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The role of small extracellular vesicles in cerebral and myocardial ischemia—Molecular signals, treatment targets, and future clinical translation by Zheng, Xuan, Hermann, Dirk M., Bähr, Mathias, Doeppner, Thorsten R.

“…The heart and the brain mutually interact with each other, forming a functional axis that is disturbed under conditions of ischemia. Stem cell‐derived…”
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Hot Topics in Cellular Neuropathology II: Promoting Neuronal Plasticity in the Injured Central Nervous System by Hermann, Dirk M.

“…Photographs of his silver nitrate stainings, which he advanced based on Camillo Golgi's (1843–1926) protocols, are legendary. Besides others, Ramon y Cajal…”
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Polymorphonuclear Neutrophils Play a Decisive Role for Brain Injury and Neurological Recovery Poststroke by Hermann, Dirk M, Gunzer, Matthias

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Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-β/Smad2/3 pathway by Zhang, Lin, Wei, Wei, Ai, Xiaoyu, Kilic, Ertugrul, Hermann, Dirk M., Venkataramani, Vivek, Bähr, Mathias, Doeppner, Thorsten R.

“…Systemic transplantation of oxygen−glucose deprivation (OGD)-preconditioned primary microglia enhances neurological recovery in rodent stroke models, albeit…”
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Lost in the Translation Trap: Quest for a Research Reporting Culture That More Carefully Weighs Clinical Applicability in Experimental Disease Models by Hermann, Dirk M

“…In many disease areas, specifically in ischemic stroke or neurodegenerative diseases, we do not have any disease-modifying therapies at hand, allowing us to…”
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Extracellular Vesicles Improve Post‐Stroke Neuroregeneration and Prevent Postischemic Immunosuppression by Doeppner, Thorsten R., Herz, Josephine, Görgens, André, Schlechter, Jana, Ludwig, Anna-Kristin, Radtke, Stefan, de Miroschedji, Kyra, Horn, Peter A., Giebel, Bernd, Hermann, Dirk M.

“…The effects of mesenchymal stem cell (MSC)‐derived extracellular vesicles were compared with those of MSCs i.v. delivered 1, 3, and 5 days or 1 day after focal…”
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Ischemic stroke and concomitant gastrointestinal complications- a fatal combination for patient recovery by Tuz, Ali A., Hasenberg, Anja, Hermann, Dirk M., Gunzer, Matthias, Singh, Vikramjeet

“…Stroke is primarily a neurodegenerative disease but can also severely impact the functions of other vital organs and deteriorate disease outcomes. A…”
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Hot Topics in Cellular Neuropathology by Hermann, Dirk M

“…[...]CRISPR/Cas9 has become a cornerstone in biotechnology in the last 8 years. Developments in molecular biology and genetics accelerated developments in…”
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Identification of transcriptome alterations in the prefrontal cortex, hippocampus, amygdala and hippocampus of suicide victims by Glavan, Daniela, Gheorman, Victor, Gresita, Andrei, Hermann, Dirk M., Udristoiu, Ion, Popa-Wagner, Aurel

“…Suicide is one of the leading causes of death globally for all ages, and as such presents a very serious problem for clinicians worldwide. However, the…”
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3D visualization and quantification of microvessels in the whole ischemic mouse brain using solvent-based clearing and light sheet microscopy by Lugo-Hernandez, Erlen, Squire, Anthony, Hagemann, Nina, Brenzel, Alexandra, Sardari, Maryam, Schlechter, Jana, Sanchez-Mendoza, Eduardo H, Gunzer, Matthias, Faissner, Andreas, Hermann, Dirk M

“…The visualization of cerebral microvessels is essential for understanding brain remodeling after stroke. Injection of dyes allows for the evaluation of…”
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Editorial: Human brain organoids to model neurodegenerative diseases at the BOSS23 Brain Organoid Summer School by Cavaliere, Fabio, Hermann, Dirk M., Magliaro, Chiara

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Signaling roles of sphingolipids in the ischemic brain and their potential utility as therapeutic targets by Mohamud Yusuf, Ayan, Zhang, Xiaoni, Gulbins, Erich, Peng, Ying, Hagemann, Nina, Hermann, Dirk M.

“…Sphingolipids comprise a class of lipids, which are composed of a sphingoid base backbone and are essential structural components of cell membranes. Beyond…”
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Effects of vascular endothelial growth factor in ischemic stroke by Ma, Yihui, Zechariah, Anil, Qu, Yan, Hermann, Dirk M.

“…Vascular endothelial growth factor (VEGF) is a pleiotropic growth factor that is crucially involved in neurovascular remodeling in the ischemic brain. VEGF…”
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Sleep-related breathing and sleep-wake disturbances in ischemic stroke by HERMANN, Dirk M, BASSETTI, Claudio L

“…Sleep-related breathing disturbances (SDB) and sleep-wake disturbances (SWD) are often neglected in stroke patients. Recent studies suggest that they are…”
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Roles of Polymorphonuclear Neutrophils in Ischemic Brain Injury and Post-Ischemic Brain Remodeling by Mohamud Yusuf, Ayan, Hagemann, Nina, Ludewig, Peter, Gunzer, Matthias, Hermann, Dirk M

“…Following ischemic stroke, polymorphonuclear neutrophils (PMNs) are rapidly recruited to the ischemic brain tissue and exacerbate stroke injury by release of…”
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