Search Results - "Dirix, LY"

Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients by DIRLX, L. Y, VERMEUEEN, P. B, PAWINSKI, A, PROVE, A, BENOY, I, DE POOTER, C, MARTIN, M, VAN OOSTEROM, A. T

“…The concentration of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) was determined in the serum of 90 untreated and 42…”
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Pathological features of vessel co-option versus sprouting angiogenesis by Latacz, Emily, Caspani, Elisabetta, Barnhill, Raymond, Lugassy, Claire, Verhoef, Cornelis, Grünhagen, Dirk, Van Laere, Steven, Fernández Moro, Carlos, Gerling, Marco, Dirix, Marie, Dirix, Luc Y., Vermeulen, Peter B.

“…Cancer cells can use existing blood vessels to acquire a vasculature. This process is termed ‘vessel co-option’. Vessel co-option is an alternative to the…”
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Impact of age on breast cancer mortality and competing causes of death at 10 years follow-up in the adjuvant TEAM trial by Derks, M.G.M., Bastiaannet, E., van de Water, W., de Glas, N.A., Seynaeve, C., Putter, H., Nortier, J.W.R., Rea, D., Hasenburg, A., Markopoulos, C., Dirix, L.Y., Portielje, J.E.A., van de Velde, C.J.H., Liefers, G.J.

“…Due to increasing life expectancy, patients with breast cancer remain at risk of dying due to breast cancer over a long time. This study aims to assess the…”
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Docetaxel (Taxotere ) in advanced gastric cancer: results of a phase II clinical trial. EORTC Early Clinical Trials Group by Sulkes, A, Smyth, J, Sessa, C, Dirix, L Y, Vermorken, J B, Kaye, S, Wanders, J, Franklin, H, LeBail, N, Verweij, J

“…Thirty-seven eligible patients, median age 59 years (range 37-72) and median performance status 1 (0-2), with advanced, untreated, measurable gastric carcinoma…”
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Abstract PD9-08: Breast cancer liver metastases vascularize by vessel co-option, not angiogenesis, and have a desert immune phenotype: A histopathological and gene expression study by Vermeulen, PB, van Dam, P-J, Daelemans, S, Latacz, E, Joye, I, Kockx, M, Dirix, P, Verhoef, K, Grunhagen, D, Huget, P, Van Laere, S, Dirix, LY

“…Abstract Phase 3 trials of bevacizumab combined with chemotherapy in metastatic breast cancer have consistently failed to demonstrate a survival benefit for…”
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Circulating interleukin‐6 predicts survival in patients with metastatic breast cancer by Salgado, Roberto, Junius, Sara, Benoy, Ina, Van Dam, Peter, Vermeulen, Peter, Van Marck, Eric, Huget, Philippe, Dirix, Luc Y.

“…Interleukin‐6 (IL‐6) is a multifunctional cytokine produced by macrophages, T cells, B cells, endothelial cells and tumour cells. Interleukin‐6 is able to…”
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Comparative Proteome Analysis Revealing an 11-Protein Signature for Aggressive Triple-Negative Breast Cancer by NING QING LIU, STINGL, Christoph, MANGIA, Anita, PARADISO, Angelo, DIRIX, Luc Y, VAN LAERE, Steven J, LUIDER, Theo M, MARTENS, John W. M, FOEKENS, John A, UMAR, Arzu, LOOK, Maxime P, SMID, Marcel, BRAAKMAN, René B. H, DE MARCHI, Tommaso, SIEUWERTS, Anieta M, SPAN, Paul N, SWEEP, Fred C. G. J, LINDERHOLM, Barbro K

“…Clinical outcome of patients with triple-negative breast cancer (TNBC) is highly variable. This study aims to identify and validate a prognostic protein…”
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Increased Serum Interleukin-8 in Patients with Early and Metastatic Breast Cancer Correlates with Early Dissemination and Survival by BENOY, Ina H, SALGADO, Roberto, VAN DAM, Peter, GEBOERS, Katrien, VAN MARCK, Eric, SCHARPE, Simon, VERMEULEN, Peter B, DIRIX, Luc Y

“…Purpose: The prognostic significance of serum interleukin (IL)-8 was evaluated in patients with metastatic breast cancer. The predictive value of serum IL-8…”
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First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours by VAN DER AUWERA, I, CAO, Y, TILLE, J. C, PEPPER, M. S, JACKSON, D. G, FOX, S. B, HARRIS, A. L, DIRIX, L. Y, VERMEULEN, P. B

“…The lymphatic system is the primary pathway of metastasis for most human cancers. Recent research efforts in studying lymphangiogenesis have suggested the…”
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Role of combination therapy with aromatase and cyclooxygenase-2 inhibitors in patients with metastatic breast cancer by Falandry, C., Canney, P. A., Freyer, G., Dirix, L. Y.

“…Aromatase inhibitors (AIs) are well established in the treatment of metastatic hormone-sensitive breast cancer in postmenopausal women. Cyclooxygenase (COX)-2…”
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Abstract S1-04: Avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with locally advanced or metastatic breast cancer: A phase Ib JAVELIN solid tumor trial by Dirix, LY, Takacs, I, Nikolinakos, P, Jerusalem, G, Arkenau, H-T, Hamilton, EP, von Heydebreck, A, Grote, H-J, Chin, K, Lippman, ME

“…Abstract Background: The programmed death-1 receptor (PD-1) and its ligand (PD-L1) are key therapeutic targets in the reactivation of the immune response…”
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Real-time RT-PCR detection of disseminated tumour cells in bone marrow has superior prognostic significance in comparison with circulating tumour cells in patients with breast cancer by BENOY, I. H, ELST, H, PHILIPS, M, WUYTS, H, VAN DAM, P, SCHARPE, S, VAN MARCK, E, VERMEULEN, P. B, DIRIX, L. Y

“…This study assessed the ability of real-time reverse transcription-polymerase chain reaction (RT-PCR) analysis to detect disseminated epithelial cells (DEC) in…”
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Abstract P1-02-02: ESR1 mutations in circulating tumor cell versus circulating cell-free DNA of metastatic breast cancer patients before first-line endocrine therapy and at progression by Sieuwerts, AM, Beije, N, Kraan, J, Van, M, Onstenk, W, Vitale, SR, van der Vlugt – Daane, M, Hamberg, P, Dirix, LY, Brouwers, A, de Jongh, FE, Jager, A, Seynaeve, CM, Jansen, MPHM, Foekens, JA, Martens, JWM, Sleijfer, S

“…Abstract Background Mutations in ESR1, the gene encoding the estrogen receptor, have been linked to endocrine resistance in metastatic breast cancer (MBC). It…”
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Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours by Vermeulen, P.B., Gasparini, G., Fox, S.B., Colpaert, C., Marson, L.P., Gion, M., Beliën, J.A.M., de Waal, R.M.W., Van Marck, E., Magnani, E., Weidner, N., Harris, A.L., Dirix, L.Y.

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Prevalence and heterogeneity of androgen receptor splice variants and intra-AR structural variation in patient with castration-resistant prostate cancer by Dirix, Luc Yves, De Laere, Bram, van Dam, Pieter-Jan, Whitington, Tom, Mayrhofer, Markus, Henao Diaz, Emanuela, Van den Eynden, Gert, Vandebroek, Jean, Del-Favero, Jurgen, Van Laere, Steven J, Gronberg, Henrik, Lindberg, Johan

“…Abstract only 11530 Background: Androgen receptor splice variant 7 (AR-V7) is linked to a priori resistance to abiraterone acetate and enzalutamide. However,…”
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Tumor Lymphangiogenesis in Inflammatory Breast Carcinoma: A Histomorphometric Study by VAN DER AUWERA, Ilse, VAN DEN EYNDEN, Gert G, COLPAERT, Cecile G, VAN LAERE, Steven J, VAN DAM, Peter, VAN MARCK, Eric A, DIRIX, Luc Y, VERMEULEN, Peter B

“…Purpose: At the time of diagnosis, metastatic dissemination of tumor cells via the lymphatic system has occurred in nearly all patients with inflammatory…”
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Increased Angiogenesis and Lymphangiogenesis in Inflammatory versus Noninflammatory Breast Cancer by Real-Time Reverse Transcriptase-PCR Gene Expression Quantification by VAN DER AUWERA, Ilse, VAN LAERE, Steven J, VERMEULEN, Peter B, DIRIX, Luc Y, VAN DEN EYNDEN, Gert G, BENOY, Ina, VAN DAM, Peter, COLPAERT, Cecile G, FOX, Stephen B, TURLEY, Helen, HARRIS, Adrian L, VAN MARCK, Eric A

“…Purpose: Inflammatory breast cancer is a distinct and aggressive form of locally advanced breast cancer with unique clinical and pathological features…”
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Liver metastases from colorectal adenocarcinomas grow in three patterns with different angiogenesis and desmoplasia by Vermeulen, Peter B., Colpaert, Cecile, Salgado, Roberto, Royers, Ruben, Hellemans, Hilde, Van den Heuvel, Eva, Goovaerts, Gerda, Dirix, Luc Y., Van Marck, Eric

“…The liver is a highly vascularized organ which frequently hosts metastases in patients with colorectal adenocarcinomas. The hypothesis of this study is that…”
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Breast adenocarcinoma liver metastases, in contrast to colorectal cancer liver metastases, display a non-angiogenic growth pattern that preserves the stroma and lacks hypoxia by STESSELS, F, VAN DEN EYNDEN, G, VERMEULEN, P. B, VAN DER AUWERA, I, SALGADO, R, VAN DEN HEUVEL, E, HARRIS, A. L, JACKSON, D. G, COLPAERT, C. G, VAN MARCK, E. A, DIRIX, L. Y

“…Although angiogenesis is a prerequisite for the growth of most human solid tumours, alternative mechanisms of vascularisation can be adopted. We have…”
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Exemestane Is Superior to Megestrol Acetate After Tamoxifen Failure in Postmenopausal Women With Advanced Breast Cancer: Results of a Phase III Randomized Double-Blind Trial by KAUFMANN, M, BAJETTA, E, FOWST, C, POLLI, A, DI SALLE, E, ARKHIPOV, A, PISCITELLI, G, MILLER, L. L, MASSIMINI, G, DIRIX, L. Y, FEIN, L. E, JONES, S. E, ZILEMBO, N, DUGARDYN, J.-L, NASURDI, C, MENNEL, R. G, CERVEK, J

“…PURPOSE: This phase III, double-blind, randomized, multicenter study evaluated the efficacy, pharmacodynamics, and safety of the oral aromatase inactivator…”
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