Search Results - "Dirig, D M"

Intrathecal baclofen and muscimol, but not midazolam, are antinociceptive using the rat-formalin model by Dirig, D M, Yaksh, T L

“…Both gamma-aminobutyric acid (GABA)A and GABAB receptor subtypes have been implicated in spinally mediated antinociception in acute pain models. In the current…”
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Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli by Dirig, David M., Salami, Ali, Rathbun, Michael L., Ozaki, George T., Yaksh, Tony L.

“…We have examined the stability and sources of variation within the nociceptive model of rat hind paw withdrawal from an under-glass radiant stimulus (…”
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In vitro prostanoid release from spinal cord following peripheral inflammation: effects of substance P, NMDA and capsaicin by Dirig, David M, Yaksh, Tony L

“…Spinal prostanoids are implicated in the development of thermal hyperalgesia after peripheral injury, but the specific prostanoid species that are involved are…”
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Thermal hyperalgesia in rat evoked by intrathecal substance P at multiple stimulus intensities reflects an increase in the gain of nociceptive processing by Dirig, David M., Yaksh, Tony L.

“…Substance P (SP) is associated with primary afferent depolarization after a noxious or tissue-damaging peripheral stimulus and is proposed to be a ‘pain…”
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Mechanism of Action of Nonsteroidal Anti-inflammatory Drugs by Yaksh, Tony L., Dirig, David M., Malmberg, Annika B.

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Differential right shifts in the dose-response curve for intrathecal morphine and sufentanil as a function of stimulus intensity by Dirig, David M, Yaksh, Tony L

“…To assess effects of stimulus intensity, dose-response curves in rats for radiant heat-evoked withdrawal of the hind paw was assessed after the intrathecal…”
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Evidence for differences in cultured left ventricular fibroblast populations isolated from spontaneously hypertensive and Wistar-Kyoto rats by Klett, C P, Palmer, A A, Dirig, D M, Gallagher, A M, Riosecco-Camacho, N, Printz, M P

“…To compare fibroblast populations derived from spontaneously hypertensive rats (SHRLJ) and normotensive Wistar-Kyoto rats (WKYLJ) for angiotensin II receptor…”
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Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats by Dirig, D M, Isakson, P C, Yaksh, T L

“…Intrathecal administration of nonsteroidal anti-inflammatory drugs in the rat blocks the thermal hyperalgesia induced by tissue injury, which suggests a role…”
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Temperature Dependency of Basal and Evoked Release of Amino Acids and Calcitonin Gene-Related Peptide from Rat Dorsal Spinal Cord by Dirig, David M, Hua, Xiao-Ying, Yaksh, Tony L

“…Moderate hypothermia significantly diminishes consequences of spinal and cerebral anoxia. One component of this neuroprotection has been hypothesized to be…”
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Effect of spinal cyclooxygenase inhibitors in rat using the formalin test and in vitro prostaglandin E2 release by DIRIG, D. M, KONIN, G. P, ISAKSON, P. C, YAKSH, T. L

“…Spinally delivery of the non-specific cyclooxygenase inhibitor, S(+)-ibuprofen, reduces the second phase of the formalin test and the evoked release of…”
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Spinal synthesis and release of prostanoids after peripheral injury and inflammation by Dirig, D M, Yaksh, T L

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The Acute Antihyperalgesic Action of Nonsteroidal, Anti-Inflammatory Drugs and Release of Spinal Prostaglandin E2 Is Mediated by the Inhibition of Constitutive Spinal Cyclooxygenase-2 (COX-2) but not COX-1 by Yaksh, Tony L, Dirig, David M, Conway, Charles M, Svensson, Camilla, Luo, Z. David, Isakson, Peter C

“…Western blots show the constitutive expression of COX-1 and COX-2 in the rat spinal dorsal and ventral horns and in the dorsal root ganglia. Using selective…”
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Hyperalgesia-associated spinal synthesis and release of prostaglandins by Dirig, D M, Yaksh, T L

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The Acute Antihyperalgesic Action of Nonsteroidal, Anti-Inflammatory Drugs and Release of Spinal Prostaglandin E 2 Is Mediated by the Inhibition of Constitutive Spinal Cyclooxygenase-2 (COX-2) but not COX-1 by Yaksh, Tony L., Dirig, David M., Conway, Charles M., Svensson, Camilla, Luo, Z. David, Isakson, Peter C.

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The Acute Antihyperalgesic Action of Nonsteroidal, Anti-Inflammatory Drugs and Release of Spinal Prostaglandin E sub(2) Is Mediated by the Inhibition of Constitutive Spinal Cyclooxygenase-2 (COX-2) but not COX-1 by Yaksh, T L, Dirig, D M, Conway, C M, Svensson, C, Luo, Z D, Isakson, P C

“…Western blots show the constitutive expression of COX-1 and COX-2 in the rat spinal dorsal and ventral horns and in the dorsal root ganglia. Using selective…”
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Effect of spinal cyclooxygenase inhibitors in rat using the formalin test and in vitro prostaglandin E 2 release by Dirig, David M, Konin, Gabrielle P, Isakson, Peter C, Yaksh, Tony L

“…Spinally delivery of the non-specific cyclooxygenase inhibitor, S(+)-ibuprofen, reduces the second phase of the formalin test and the evoked release of…”
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