Stereostructure-activity relationships of the GABA-containing cis-decahydroquinoline-5-carboxylic acids; intracerebroventricular studies in mice

Two cis-decahydroquinoline-5-carboxylic acids, cis-1 and 2 were investigated for their pharmacological activities in vivo. Intracerebroventricular administration of either agent elicited convulsant activity in mice. This convulsant effect can be antagonized by pretreating the mice with n-dipropylace...

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Bibliographic Details
Published in:	Research communications in chemical pathology and pharmacology Vol. 39; no. 3; p. 367
Main Authors:	Fung, Y K, Bero, C, Dircks, D, Tomita, K, Patch, R J, Witiak, D T
Format:	Journal Article
Language:	English
Published:	United States 01-01-1983
Subjects:	Animals Apomorphine - pharmacology Behavior, Animal - drug effects Convulsants gamma-Aminobutyric Acid - physiology Injections, Intraventricular Male Mice Mice, Inbred ICR Picrotoxin - pharmacology Quinolines - pharmacology Stereoisomerism Structure-Activity Relationship Valproic Acid - pharmacology
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Summary:	Two cis-decahydroquinoline-5-carboxylic acids, cis-1 and 2 were investigated for their pharmacological activities in vivo. Intracerebroventricular administration of either agent elicited convulsant activity in mice. This convulsant effect can be antagonized by pretreating the mice with n-dipropylacetate (valproate). Our results suggest that cis-1 may act indirectly as a partial gamma-aminobutyric acid (GABA) agonist in vivo. On the other hand, both cis-1 and 2, at higher concentrations, exhibit properties of a GABA-antagonist, but this effect seems not to be due to GABA receptor binding.
ISSN:	0034-5164