Search Results - "Dippel, Andrew"

In Vivo Biochemistry: Single-Cell Dynamics of Cyclic Di-GMP in Escherichia coli in Response to Zinc Overload by Yeo, Jongchan, Dippel, Andrew B, Wang, Xin C, Hammond, Ming C

“…Intracellular signaling enzymes drive critical changes in cellular physiology and gene expression, but their endogenous activities in vivo remain highly…”
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A Poxin on Both of Your Houses: Poxviruses Degrade the Immune Signal cGAMP by Dippel, Andrew B, Hammond, Ming C

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Development of Ratiometric Bioluminescent Sensors for in Vivo Detection of Bacterial Signaling by Dippel, Andrew B, Anderson, Wyatt A, Park, Jin Hwan, Yildiz, Fitnat H, Hammond, Ming C

“…Second messenger signaling networks allow cells to sense and adapt to changing environmental conditions. In bacteria, the nearly ubiquitous second messenger…”
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Toward enhancement of antibody thermostability and affinity by computational design in the absence of antigen by Hutchinson, Mark, Ruffolo, Jeffrey A, Haskins, Nantaporn, Iannotti, Michael, Vozza, Giuliana, Pham, Tony, Mehzabeen, Nurjahan, Shandilya, Harini, Rickert, Keith, Croasdale-Wood, Rebecca, Damschroder, Melissa, Fu, Ying, Dippel, Andrew, Gray, Jeffrey J, Kaplan, Gilad

“…Over the past two decades, therapeutic antibodies have emerged as a rapidly expanding domain within the field of biologics. tools that can streamline the…”
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Chemiluminescent sensors for quantitation of the bacterial second messenger cyclic di-GMP by Anderson, Wyatt A, Dippel, Andrew B, Maiden, Michael M, Waters, Christopher M, Hammond, Ming C

“…Chemiluminescent biosensors have been developed and broadly applied to mammalian cell systems for studying intracellular signaling networks. For bacteria,…”
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Tuning the Innate Immune Response to Cyclic Dinucleotides by Using Atomic Mutagenesis by Li, Yao, Fin, Andrea, Rovira, Alexander R., Su, Yichi, Dippel, Andrew B., Valderrama, Jonathan Andrés, Riestra, Angelica M., Nizet, Victor, Hammond, Ming C., Tor, Yitzhak

“…Cyclic dinucleotides (CDNs) trigger the innate immune response in eukaryotic cells through the stimulator of interferon genes (STING) signaling pathway. To…”
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IL-2-armored peptide-major histocompatibility class I bispecific antibodies redirect antiviral effector memory CD8+ T cells to induce potent anti-cancer cytotoxic activity with limited cytokine release by Schardt, John S, Walseng, Even, Le, Kim, Yang, Chunning, Shah, Pooja, Fu, Ying, Alam, Kausar, Kelton, Cathryn R, Gu, Yu, Huang, Fengying, Lin, Jia, Liu, Wenhai, Dippel, Andrew, Zhang, Hanzhi, Mulgrew, Kathy, Pryts, Stacy, Chennupati, Vijaykumar, Chen, Hung-Chang, Denham, Jessica, Chen, Xiaoru, Pradhan, Pallab, Wu, Yuling, Hardman, Colin, Zhao, Chihao, Kierny, Michael, Song, Yang, Dovedi, Simon J, Cemerski, Saso, Mazor, Yariv

“…T cell engagers (TCEs) are becoming an integral class of biological therapeutic owing to their highly potent ability to eradicate cancer cells. Nevertheless,…”
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Probing the effectiveness of spectroscopic reporter unnatural amino acids: a structural study by Dippel, Andrew B., Olenginski, Gregory M., Maurici, Nicole, Liskov, Melanie T., Brewer, Scott H., Phillips-Piro, Christine M.

“…The X‐ray crystal structures of superfolder green fluorescent protein (sfGFP) containing the spectroscopic reporter unnatural amino acids (UAAs)…”
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Developability profiling of a panel of Fc engineered SARS-CoV-2 neutralizing antibodies by Dippel, Andrew, Gallegos, Austin, Aleti, Vineela, Barnes, Arnita, Chen, Xiaoru, Christian, Elizabeth, Delmar, Jared, Du, Qun, Esfandiary, Reza, Farmer, Erika, Garcia, Andrew, Li, Qing, Lin, Jia, Liu, Weiyi, Machiesky, LeeAnn, Mody, Neil, Parupudi, Arun, Prophet, Meagan, Rickert, Keith, Rosenthal, Kim, Ren, Song, Shandilya, Harini, Varkey, Reena, Wons, Kevin, Wu, Yuling, Loo, Yueh-Ming, Esser, Mark T, Kallewaard, Nicole L, Rajan, Sarav, Damschroder, Melissa, Xu, Weichen, Kaplan, Gilad

“…To combat the COVID-19 pandemic, potential therapies have been developed and moved into clinical trials at an unprecedented pace. Some of the most promising…”
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Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-Cλ interface by Bagert, John D, Oganesyan, Vaheh, Chiang, Chi-I, Iannotti, Mike, Lin, Jia, Yang, Chunning, Payne, Sterling, McMahon, Will, Edwards, Samuel, Dippel, Andrew, Hutchinson, Mark, Huang, Fengying, Aleti, Vineela, Niu, Chendi, Qian, Chen, Denham, Jessica, Ferreira, Sofia, Pradhan, Pallab, Penney, Mark, Wang, Chunlei, Liu, Wenhai, Walseng, Even, Mazor, Yariv

“…Bispecific antibodies represent an increasingly large fraction of biologics in therapeutic development due to their expanded scope in functional capabilities…”
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Chemiluminescent Biosensors for Detection of Second Messenger Cyclic di-GMP by Dippel, Andrew B, Anderson, Wyatt A, Evans, Robert S, Deutsch, Samuel, Hammond, Ming C

“…Bacteria colonize highly diverse and complex environments, from gastrointestinal tracts to soil and plant surfaces. This colonization process is controlled in…”
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First Disclosure of AZD9829, a TOP1i-ADC Targeting CD123: Promising Preclinical Activity in AML Models with Minimal Effect on Healthy Progenitors by Dutta, Dipannita, Pan, Pan, Fleming, Ryan, Andrade-Campos, Marcio, Belova, Elena, Wheeler, Jennifer, Cheung, Patricia, Santacroce, Paul, Daniels, Casey, Sabol, Darrin, Jakubison, Brad, Recolin, Benedicte, Dippel, Andrew, Wey, Margaret, Shaffer, Arthur, Rosfjord, Edward, Hurt, Elaine, Gorgun, Gullu, Younes, Anas, Sapra, Puja

“…CD123 is a cell surface protein that is overexpressed in several hematologic malignancies including acute myeloid leukemia (AML) and myelodysplastic syndrome…”
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A scalable and high yielding SARS-CoV-2 spike protein receptor binding domain production process by Riguero, Valeria, Delmar, Jared, Dippel, Andrew, McTamney, Patrick, Luo, Ethan, Martinez, Antonio, Ren, Kuishu, van Dyk, Nydia, O'Connor, Ellen

“…The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spike protein is of interest for the development of vaccines and therapeutics against…”
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In Vivo Biochemistry: Single-cell dynamics of cyclic di-GMP in E. coli in response to zinc overload by Yeo, Jongchan, Dippel, Andrew B., Wang, Xin C., Hammond, Ming C.

“…Intracellular signaling enzymes drive critical changes in cellular physiology and gene expression, but their endogenous activities in vivo remain highly…”
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AZD3152 neutralizes SARS-CoV-2 historical and contemporary variants and is protective in hamsters and well tolerated in adults by Cai, Yingyun, Diallo, Seme, Rosenthal, Kim, Ren, Kuishu, Flores, Daniel J, Dippel, Andrew, Oganesyan, Vaheh, van Dyk, Nydia, Chen, Xiaoru, Cantu, Erin, Choudhary, Rakesh, Sulikowski, Michal, Adissu, Hibret, Chawla, Bhavna, Kar, Swagata, Liu, Chang, Dijokaite-Guraliuc, Aiste, Mongkolsapaya, Juthathip, Rajan, Saravanan, Loo, Yueh-Ming, Beavon, Rohini, Webber, Chris, Chang, Lee-Jah, Thomas, Steven, Clegg, Lindsay, Zhang, Huixia, Screaton, Gavin R, Philbin, Nora, Harre, Mark, Selim, Abdulhafez, Martinez-Alier, Nuria, Uriel, Alison, Cohen, Taylor S, Perez, John L, Esser, Mark T, Blair, Wade, Francica, Joseph R

“…The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in variants that can escape neutralization by therapeutic…”
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Chemiluminescent Biosensors for Detection of Second Messenger Cyclic di-GMP by Dippel, Andrew B., Anderson, Wyatt A., Evans, Robert S., Deutsch, Samuel, Hammond, Ming C.

“…Bacteria colonize highly diverse and complex environments, from gastrointestinal tracts to soil and plant surfaces. This colonization process is controlled in…”
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Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the C H 1-C λ interface by Bagert, John D, Oganesyan, Vaheh, Chiang, Chi-I, Iannotti, Mike, Lin, Jia, Yang, Chunning, Payne, Sterling, McMahon, Will, Edwards, Samuel, Dippel, Andrew, Hutchinson, Mark, Huang, Fengying, Aleti, Vineela, Niu, Chendi, Qian, Chen, Denham, Jessica, Ferreira, Sofia, Pradhan, Pallab, Penney, Mark, Wang, Chunlei, Liu, Wenhai, Walseng, Even, Mazor, Yariv

“…Bispecific antibodies represent an increasingly large fraction of biologics in therapeutic development due to their expanded scope in functional capabilities…”
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Probing Structural Implications of Unnatural Amino Acid Incorporation into Green Fluorescent Protein by Maurici, Nicole, Dippel, Andrew, Liskov, Melanie, Brewer, Scott, Phillips-Piro, Christine

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1355. The SARS-CoV-2 Monoclonal Antibody AZD3152 Potently Neutralizes Historical and Emerging Variants and is Being Developed for the Prevention and Treatment of COVID-19 in High-risk Individuals by Francica, Joseph R, Cai, Yingyun, Diallo, Seme, Rosenthal, Kim, Ren, Kuishu, Flores, Daniel J, Dippel, Andrew, Wu, Yuling, Chen, Xiaoru, Cantu, Erin, Choudhary, Rakesh, Sulikowski, Michal, Adissu, Hibret, Chawla, Bhavna, Kar, Swagata, van Dyk, Nydia, Oganesyan, Vaheh, Rajan, Saravanan, Ryan, Patricia C, Loo, Yueh-Ming, Cohen, Taylor, Esser, Mark T, Blair, Wade

“…Abstract Background EVUSHELD was developed for the prevention and treatment of mild-to-moderate COVID-19 for high-risk individuals. However, the SARS-CoV-2…”
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Development of Bioluminescent Sensors for Interrogating Cyclic Di-Nucleotide Signaling by Dippel, Andrew B

“…Bioluminescence is the spectacular natural phenomenon in which living organisms produce and emit light. Natural bioluminescent protein systems have been…”
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