Search Results - "Dipersio, C Michael"

Beyond adhesion: emerging roles for integrins in control of the tumor microenvironment [version 1; peer review: 4 approved] by Longmate, Whitney, DiPersio, C Michael

“…While integrins were originally discovered as cell adhesion receptors, recent studies have reinforced the concept that integrins have central roles in cancer…”
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Establishment of a Murine Pro-acinar Cell Line to Characterize Roles for FGF2 and α3β1 Integrins in Regulating Pro-acinar Characteristics by Thiemann, Renée F., Nelson, Deirdre A., Michael DiPersio, C., Larsen, Melinda, LaFlamme, Susan E.

“…Radiation therapy for head and neck cancers results in permanent damage to the saliva producing acinar compartment of the salivary gland. To date, a pure…”
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Integrin Regulation of CAF Differentiation and Function by DiPersio, C Michael, Van De Water, Livingston

“…Extensive remodeling of the extracellular matrix, together with paracrine communication between tumor cells and stromal cells, contribute to an "activated"…”
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Comparative use of CRISPR and RNAi to modulate integrin α3β1 in triple negative breast cancer cells reveals that some pro-invasive/pro-metastatic α3β1 functions are independent of global regulation of the transcriptome by Kenney, James, Ndoye, Abibatou, Lamar, John M., DiPersio, C. Michael

“…Integrin receptors for the extracellular matrix play critical roles at all stages of carcinogenesis, including tumor growth, tumor progression and metastasis…”
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Integrin α3β1 Promotes Invasive and Metastatic Properties of Breast Cancer Cells through Induction of the Brn-2 Transcription Factor by Miskin, Rakshitha Pandulal, Warren, Janine S A, Ndoye, Abibatou, Wu, Lei, Lamar, John M, DiPersio, C Michael

“…In the current study, we demonstrate that integrin α3β1 promotes invasive and metastatic traits of triple-negative breast cancer (TNBC) cells through induction…”
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Integrin α3β1 signaling through MEK/ERK determines alternative polyadenylation of the MMP-9 mRNA transcript in immortalized mouse keratinocytes by Missan, Dara S, Mitchell, Kara, Subbaram, Sita, DiPersio, C Michael

“…Integrin α3β1 is highly expressed in both normal and tumorigenic epidermal keratinocytes where it regulates genes that control cellular function and…”
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Suppression of Integrin α3β1 in Breast Cancer Cells Reduces Cyclooxygenase-2 Gene Expression and Inhibits Tumorigenesis, Invasion, and Cross-Talk to Endothelial Cells by MITCHELL, Kara, SVENSON, Kimberly B, LONGMATE, Whitney M, GKIRTZIMANAKI, Katerina, SADEJ, Rafal, XIANHUI WANG, JIHE ZHAO, ELIOPOULOS, Aristides G, BERDITCHEVSKI, Fedor, MICHAEL DIPERSIO, C

“…Integrin receptors for cell adhesion to extracellular matrix have important roles in promoting tumor growth and progression. Integrin α3β1 is highly expressed…”
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Roles for epithelial integrin α3β1 in regulation of the microenvironment during normal and pathological tissue remodeling by Miskin, Rakshitha Pandulal, DiPersio, C Michael

“…Integrin receptors for the extracellular matrix activate intracellular signaling pathways that are critical for tissue development, homeostasis, and…”
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An Immortalization -Dependent Switch in Integrin Function Up-regulates MMP-9 to Enhance Tumor Cell Invasion by LAMAR, John M, PUMIGLIA, Kevin M, DIPERSIO, C. Michael

“…Integrins, the major receptors for cell adhesion to the extracellular matrix, play important roles during tumor progression. However, it is still unclear…”
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Epidermal Integrin α3β1 Regulates Tumor-Derived Proteases BMP-1, Matrix Metalloprotease-9, and Matrix Metalloprotease-3 by Longmate, Whitney M., Miskin, Rakshitha Pandulal, Van De Water, Livingston, DiPersio, C. Michael

“…As the major cell surface receptors for the extracellular matrix, integrins regulate adhesion and migration and have been shown to drive tumor growth and…”
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Integrin-mediated regulation of epidermal wound functions by DiPersio, C. Michael, Zheng, Rui, Kenney, James, Van De Water, Livingston

“…During cutaneous wound healing, keratinocyte proliferation and migration are critical for re-epithelialization. In addition the epidermis secretes growth…”
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What does it take to be a collagen receptor? by Farndale, Richard, Sonnenberg, Arnoud, DiPersio, C. Michael, Eble, Johannes A, Heino, Jyrki, Gullberg, Donald

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Novel Roles for α3β1 Integrin as a Regulator of Cytoskeletal Assembly and as a Trans-Dominant Inhibitor of Integrin Receptor Function in Mouse Keratinocytes by Hodivala-Dilke, Kairbaan M., DiPersio, C. Michael, Kreidberg, Jordan A., Hynes, Richard O.

“…Previously we found that α3β1 integrin-deficient neonatal mice develop micro-blisters at the epidermal-dermal junction. These micro-blisters were associated…”
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β1 integrins regulate cellular behaviour and cardiomyocyte organization during ventricular wall formation by Miao, Lianjie, Lu, Yangyang, Nusrat, Anika, Zhao, Luqi, Castillo, Micah, Xiao, Yongqi, Guo, Hongyang, Liu, Yu, Gunaratne, Preethi, Schwartz, Robert J, Burns, Alan R, Kumar, Ashok, DiPersio, C Michael, Wu, Mingfu

“…Abstract Aims The mechanisms regulating the cellular behaviour and cardiomyocyte organization during ventricular wall morphogenesis are poorly understood…”
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Integrin α3β1 Represses Reelin Expression in Breast Cancer Cells to Promote Invasion by Ndoye, Abibatou, Miskin, Rakshitha Pandulal, DiPersio, C Michael

“…Integrin α3β1, a cell adhesion receptor for certain laminins, is known to promote breast tumor growth and invasion. Our previous gene microarray study showed…”
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Keratinocyte Integrin α3β1 Promotes Secretion of IL-1α to Effect Paracrine Regulation of Fibroblast Gene Expression and Differentiation by Zheng, Rui, Longmate, Whitney M., DeFreest, Lori, Varney, Scott, Wu, Lei, DiPersio, C. Michael, Van De Water, Livingston

“…After cutaneous injury, keratinocytes secrete paracrine factors that regulate wound cell functions; dysregulation of this signaling can lead to wound…”
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Loss of Integrin α9β1 on Tumor Keratinocytes Enhances the Stromal Vasculature and Growth of Cutaneous Tumors by Varney, Scott D., Wu, Lei, Longmate, Whitney M., DiPersio, C. Michael, Van De Water, Livingston

“…Angiogenesis is critical to tumor progression, and the function of integrins in tumor angiogenesis is complex. In this study, we report that loss of integrin…”
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Resolvin D2-G-Protein Coupled Receptor 18 Enhances Bone Marrow Function and Limits Steatosis and Hepatic Collagen Accumulation in Aging by Fitzgerald, Hannah, Bonin, Jesse L, Khan, Sayeed, Eid, Maya, Sadhu, Sudeshna, Rahtes, Allison, Lipscomb, Masharh, Biswas, Nirupam, Decker, Christa, Nabage, Melisande, Ramos, Ramon Bossardi, Duarte, Giesse Albeche, Marinello, Michael, Chen, Anne, Aydin, Hasan Basri, Mena, Hebe Agustina, Gilliard, Kurrim, Spite, Matthew, DiPersio, C Michael, Adam, Alejandro P, MacNamara, Katherine C, Fredman, Gabrielle

“…Aging is associated with nonresolving inflammation and tissue dysfunction. Resolvin D2 (RvD2) is a proresolving ligand that acts through the G-protein-coupled…”
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Keratinocyte integrin α3β1 induces expression of the macrophage stimulating factor, CSF-1, through a YAP/TEAD-dependent mechanism by Longmate, Whitney M., Norton, Emily, Duarte, Giesse Albeche, Wu, Lei, DiPersio, Mathieu R., Lamar, John M., DiPersio, C. Michael

“…The development of wound therapy targeting integrins is hampered by inadequate understanding of integrin function in cutaneous wound healing and the wound…”
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Integrin α3β1 as a breast cancer target by Subbaram, Sita, Dipersio, C Michael

“…Integrin receptors for cell adhesion to the extracellular matrix have important roles in all stages of cancer progression and metastasis. Since the integrin…”
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