Search Results - "Diogo, Dorothee"

Phenome-wide association studies across large population cohorts support drug target validation by Diogo, Dorothée, Tian, Chao, Franklin, Christopher S., Alanne-Kinnunen, Mervi, March, Michael, Spencer, Chris C. A., Vangjeli, Ciara, Weale, Michael E., Mattsson, Hannele, Kilpeläinen, Elina, Sleiman, Patrick M. A., Reilly, Dermot F., McElwee, Joshua, Maranville, Joseph C., Chatterjee, Arnaub K., Bhandari, Aman, Nguyen, Khanh-Dung H., Estrada, Karol, Reeve, Mary-Pat, Hutz, Janna, Bing, Nan, John, Sally, MacArthur, Daniel G., Salomaa, Veikko, Ripatti, Samuli, Hakonarson, Hakon, Daly, Mark J., Palotie, Aarno, Hinds, David A., Donnelly, Peter, Fox, Caroline S., Day-Williams, Aaron G., Plenge, Robert M., Runz, Heiko

“…Phenome-wide association studies (PheWAS) have been proposed as a possible aid in drug development through elucidating mechanisms of action, identifying…”
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Tyk2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits by Diogo, Dorothée, Bastarache, Lisa, Liao, Katherine P., Graham, Robert R., Fulton, Robert S., Greenberg, Jeffrey D., Eyre, Steve, Bowes, John, Cui, Jing, Lee, Annette, Pappas, Dimitrios A., Kremer, Joel M., Barton, Anne, Coenen, Marieke J. H., Franke, Barbara, Kiemeney, Lambertus A., Mariette, Xavier, Richard-Miceli, Corrine, Canhao, Helena, Fonseca, João, de Vries, Niek, Tak, Paul P., Crusius, J. Bart A., Nurmohamed, Michael T., Kurreeman, Fina, Mikuls, Ted R., Okada, Yukinori, Stahl, Eli A., Larson, David E., Deluca, Tracie L., O'Laughlin, Michelle, Fronick, Catrina C., Fulton, Lucinda L., Kosoy, Roman, Ransom, Michael, Bhangale, Tushar R., Ortmann, Ward, Cagan, Andrew, Gainer, Vivian, Karlson, Elizabeth W., Kohane, Isaac, Murphy, Shawn N., Martin, Javier, Zhernakova, Alexandra, Klareskog, Lars, Padyukov, Leonid, Worthington, Jane, Mardis, Elaine R., Seldin, Michael F., Gregersen, Peter K., Behrens, Timothy, Raychaudhuri, Soumya, Denny, Joshua C., Plenge, Robert M.

“…Copyright: © 2015 Diogo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits…”
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Rare, Low-Frequency, and Common Variants in the Protein-Coding Sequence of Biological Candidate Genes from GWASs Contribute to Risk of Rheumatoid Arthritis by Diogo, Dorothée, Kurreeman, Fina, Stahl, Eli A., Liao, Katherine P., Gupta, Namrata, Greenberg, Jeffrey D., Rivas, Manuel A., Hickey, Brendan, Flannick, Jason, Thomson, Brian, Guiducci, Candace, Ripke, Stephan, Adzhubey, Ivan, Barton, Anne, Kremer, Joel M., Alfredsson, Lars, Sunyaev, Shamil, Martin, Javier, Zhernakova, Alexandra, Bowes, John, Eyre, Steve, Siminovitch, Katherine A., Gregersen, Peter K., Worthington, Jane, Klareskog, Lars, Padyukov, Leonid, Raychaudhuri, Soumya, Plenge, Robert M.

“…The extent to which variants in the protein-coding sequence of genes contribute to risk of rheumatoid arthritis (RA) is unknown. In this study, we addressed…”
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Use of a Multiethnic Approach to Identify Rheumatoid- Arthritis-Susceptibility Loci, 1p36 and 17q12 by Kurreeman, Fina A.S., Stahl, Eli A., Okada, Yukinori, Liao, Katherine, Diogo, Dorothée, Raychaudhuri, Soumya, Freudenberg, Jan, Kochi, Yuta, Patsopoulos, Nikolaos A., Gupta, Namrata, Sandor, Cynthia, Bang, So-Young, Lee, Hye-Soon, Padyukov, Leonid, Suzuki, Akari, Siminovitch, Kathy, Worthington, Jane, Gregersen, Peter K., Hughes, Laura B., Reynolds, Richard J., Bridges, S. Louis, Bae, Sang-Cheol, Yamamoto, Kazuhiko, Plenge, Robert M.

“…We have previously shown that rheumatoid arthritis (RA) risk alleles overlap between different ethnic groups. Here, we utilize a multiethnic approach to show…”
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An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease by Ruotsalainen, Sanni E, Partanen, Juulia J, Cichonska, Anna, Lin, Jake, Benner, Christian, Surakka, Ida, Reeve, Mary Pat, Palta, Priit, Salmi, Marko, Jalkanen, Sirpa, Ahola-Olli, Ari, Palotie, Aarno, Salomaa, Veikko, Daly, Mark J, Pirinen, Matti, Ripatti, Samuli, Koskela, Jukka

“…Multivariate methods are known to increase the statistical power to detect associations in the case of shared genetic basis between phenotypes. They have,…”
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A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases by Han, Buhm, Pouget, Jennie G, Slowikowski, Kamil, Stahl, Eli, Lee, Cue Hyunkyu, Diogo, Dorothee, Hu, Xinli, Park, Yu Rang, Kim, Eunji, Gregersen, Peter K, Dahlqvist, Solbritt Rantapää, Worthington, Jane, Martin, Javier, Eyre, Steve, Klareskog, Lars, Huizinga, Tom, Chen, Wei-Min, Onengut-Gumuscu, Suna, Rich, Stephen S, Wray, Naomi R, Raychaudhuri, Soumya

“…Soumya Raychaudhuri, Buhm Han and colleagues present a statistical method to distinguish whether shared genetic risk variants among complex traits are driven…”
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Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway by Li, Gang, Diogo, Dorothée, Wu, Di, Spoonamore, Jim, Dancik, Vlado, Franke, Lude, Kurreeman, Fina, Rossin, Elizabeth J, Duclos, Grant, Hartland, Cathy, Zhou, Xuezhong, Li, Kejie, Liu, Jun, De Jager, Philip L, Siminovitch, Katherine A, Zhernakova, Alexandra, Raychaudhuri, Soumya, Bowes, John, Eyre, Steve, Padyukov, Leonid, Gregersen, Peter K, Worthington, Jane, Gupta, Namrata, Clemons, Paul A, Stahl, Eli, Tolliday, Nicola, Plenge, Robert M

“…Although genetic and non-genetic studies in mouse and human implicate the CD40 pathway in rheumatoid arthritis (RA), there are no approved drugs that inhibit…”
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Association between low density lipoprotein and rheumatoid arthritis genetic factors with low density lipoprotein levels in rheumatoid arthritis and non-rheumatoid arthritis controls by Liao, Katherine P, Diogo, Dorothée, Cui, Jing, Cai, Tianxi, Okada, Yukinori, Gainer, Vivian S, Murphy, Shawn N, Gupta, Namrata, Mirel, Daniel, Ananthakrishnan, Ashwin N, Szolovits, Peter, Shaw, Stanley Y, Raychaudhuri, Soumya, Churchill, Susanne, Kohane, Isaac, Karlson, Elizabeth W, Plenge, Robert M

“…While genetic determinants of low density lipoprotein (LDL) cholesterol levels are well characterised in the general population, they are understudied in…”
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Gene flow contributes to diversification of the major fungal pathogen Candida albicans by Ropars, Jeanne, Maufrais, Corinne, Diogo, Dorothée, Marcet-Houben, Marina, Perin, Aurélie, Sertour, Natacha, Mosca, Kevin, Permal, Emmanuelle, Laval, Guillaume, Bouchier, Christiane, Ma, Laurence, Schwartz, Katja, Voelz, Kerstin, May, Robin C., Poulain, Julie, Battail, Christophe, Wincker, Patrick, Borman, Andrew M., Chowdhary, Anuradha, Fan, Shangrong, Kim, Soo Hyun, Le Pape, Patrice, Romeo, Orazio, Shin, Jong Hee, Gabaldon, Toni, Sherlock, Gavin, Bougnoux, Marie-Elisabeth, d’Enfert, Christophe

“…Elucidating population structure and levels of genetic diversity and recombination is necessary to understand the evolution and adaptation of species. Candida…”
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Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway: e1003487 by Li, Gang, Diogo, Dorothée, Wu, Di, Spoonamore, Jim, Dancik, Vlado, Franke, Lude, Kurreeman, Fina, Rossin, Elizabeth J, Duclos, Grant, Hartland, Cathy, Zhou, Xuezhong, Li, Kejie, Liu, Jun, Jager, Philip LDe, Siminovitch, Katherine A, Zhernakova, Alexandra, Raychaudhuri, Soumya, Bowes, John, Eyre, Steve, Padyukov, Leonid, Gregersen, Peter K, Worthington, Jane, Gupta, Namrata, Clemons, Paul A, Stahl, Eli, Tolliday, Nicola, Plenge, Robert M

“…Although genetic and non-genetic studies in mouse and human implicate the CD40 pathway in rheumatoid arthritis (RA), there are no approved drugs that inhibit…”
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Assessing the potential of polygenic scores to strengthen medical risk prediction models of COVID-19 by Córdova-Palomera, Aldo, Siffel, Csaba, DeBoever, Chris, Wong, Emily, Diogo, Dorothée, Szalma, Sandor

“…As findings on the epidemiological and genetic risk factors for coronavirus disease-19 (COVID-19) continue to accrue, their joint power and significance for…”
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Using human genetics to improve safety assessment of therapeutics by Carss, Keren J., Deaton, Aimee M., Del Rio-Espinola, Alberto, Diogo, Dorothée, Fielden, Mark, Kulkarni, Diptee A., Moggs, Jonathan, Newham, Peter, Nelson, Matthew R., Sistare, Frank D., Ward, Lucas D., Yuan, Jing

“…Human genetics research has discovered thousands of proteins associated with complex and rare diseases. Genome-wide association studies (GWAS) and studies of…”
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Genotypic Evolution of Azole Resistance Mechanisms in Sequential Candida albicans Isolates by Coste, Alix, Selmecki, Anna, Forche, Anja, Diogo, Dorothée, Bougnoux, Marie-Elisabeth, D'Enfert, Christophe, Berman, Judith, Sanglard, Dominique

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Fine Mapping Seronegative and Seropositive Rheumatoid Arthritis to Shared and Distinct HLA Alleles by Adjusting for the Effects of Heterogeneity by Han, Buhm, Diogo, Dorothée, Eyre, Steve, Kallberg, Henrik, Zhernakova, Alexandra, Bowes, John, Padyukov, Leonid, Okada, Yukinori, González-Gay, Miguel A., Rantapää-Dahlqvist, Solbritt, Martin, Javier, Huizinga, Tom W.J., Plenge, Robert M., Worthington, Jane, Gregersen, Peter K., Klareskog, Lars, de Bakker, Paul I.W., Raychaudhuri, Soumya

“…Despite progress in defining human leukocyte antigen (HLA) alleles for anti-citrullinated-protein-autoantibody-positive (ACPA+) rheumatoid arthritis (RA),…”
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A versatile overexpression strategy in the pathogenic yeast Candida albicans: identification of regulators of morphogenesis and fitness by Chauvel, Murielle, Nesseir, Audrey, Cabral, Vitor, Znaidi, Sadri, Goyard, Sophie, Bachellier-Bassi, Sophie, Firon, Arnaud, Legrand, Mélanie, Diogo, Dorothée, Naulleau, Claire, Rossignol, Tristan, d'Enfert, Christophe

“…Candida albicans is the most frequently encountered human fungal pathogen, causing both superficial infections and life-threatening systemic diseases…”
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Molecular Phylogenetics of Candida albicans by Odds, Frank C, Bougnoux, Marie-Elisabeth, Shaw, Duncan J, Bain, Judith M, Davidson, Amanda D, Diogo, Dorothée, Jacobsen, Mette D, Lecomte, Maud, Li, Shu-Ying, Tavanti, Arianna, Maiden, Martin C J, Gow, Neil A R, d'Enfert, Christophe

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Genome-wide association studies to advance our understanding of critical cell types and pathways in rheumatoid arthritis: recent findings and challenges by Diogo, Dorothée, Okada, Yukinori, Plenge, Robert M

“…PURPOSE OF REVIEWA significant number of loci implicated in rheumatoid arthritis (RA) susceptibility have been highlighted by genome-wide association studies…”
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Quantifying missing heritability at known GWAS loci by Gusev, Alexander, Bhatia, Gaurav, Zaitlen, Noah, Vilhjalmsson, Bjarni J, Diogo, Dorothée, Stahl, Eli A, Gregersen, Peter K, Worthington, Jane, Klareskog, Lars, Raychaudhuri, Soumya, Plenge, Robert M, Pasaniuc, Bogdan, Price, Alkes L

“…Recent work has shown that much of the missing heritability of complex traits can be resolved by estimates of heritability explained by all genotyped SNPs…”
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CREdb: A comprehensive database of Cis-Regulatory Elements and their activity in human cells and tissues by Hartl, Chris, Zhuang, Jiali, Tyler, Aaron, Zhou, Bing, Wong, Emily, Merberg, David, Farrell, Brad, DeBoever, Chris, Bryant, Julie, Diogo, Dorothée

“…Cis-regulatory elements (CREs) play a pivotal role in gene expression regulation, allowing cells to serve diverse functions and respond to external stimuli…”
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The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1 by Li, Gang, Cunin, Pierre, Wu, Di, Diogo, Dorothée, Yang, Yu, Okada, Yukinori, Plenge, Robert M, Nigrovic, Peter A

“…Understanding the implications of genome-wide association studies (GWAS) for disease biology requires both identification of causal variants and definition of…”
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