Search Results - "Diogenes, Maria Jose"

Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair ltp via NMDA-receptor activation by de Oliveira Diógenes Nogueira, Maria José, Dias, Raquel, Rombo, Diogo, Vicente Miranda, Hugo, Maiolino, Francesca, Guerreiro, Patrícia, Nasstrom, Thomas, Franquelim, Henri, Oliveira, Luís M.A., Castanho, Miguel, Lannfelt, Lars, Bergstrom, Joakim, Ingelsson, Martin, Quintas, Alexandre, Sebastião, Ana M, Lopes, Luisa, Outeiro, Tiago

“…Copyright © 2012 the authors Parkinson's disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding…”
Get full text

Spatiotemporal Dysregulation of Neuron-Glia Related Genes and Pro-/Anti-Inflammatory miRNAs in the 5xFAD Mouse Model of Alzheimer's Disease by Ianni, Marta, Corraliza-Gomez, Miriam, Costa-Coelho, Tiago, Ferreira-Manso, Mafalda, Inteiro-Oliveira, Sara, Alemãn-Serrano, Nuno, Sebastião, Ana M, Garcia, Gonçalo, Diógenes, Maria José, Brites, Dora

“…Alzheimer's disease (AD), the leading cause of dementia, is a multifactorial disease influenced by aging, genetics, and environmental factors. miRNAs are…”
Get full text

Chocolate Consumption is Associated with a Lower Risk of Cognitive Decline by Moreira, Afonso, Diógenes, Maria José, de Mendonça, Alexandre, Lunet, Nuno, Barros, Henrique

“…Cocoa-related products like chocolate have taken an important place in our food habits and culture. In this work, we aim to examine the relationship between…”
Get more information

Impairment of adenosinergic system in Rett syndrome: Novel therapeutic target to boost BDNF signalling by Miranda-Lourenço, Catarina, Duarte, Sofia T., Palminha, Cátia, Gaspar, Cláudia, Rodrigues, Tiago M., Magalhães-Cardoso, Teresa, Rei, Nádia, Colino-Oliveira, Mariana, Gomes, Rui, Ferreira, Sara, Rosa, Jéssica, Xapelli, Sara, Armstrong, Judith, García-Cazorla, Àngels, Correia-de-Sá, Paulo, Sebastião, Ana M., Diógenes, Maria José

“…Rett syndrome (RTT; OMIM#312750) is mainly caused by mutations in the X-linked MECP2 gene (methyl-CpG-binding protein 2 gene; OMIM*300005), which leads to…”
Get full text

Dysregulation of TrkB receptors and BDNF function by amyloid-β peptide is mediated by calpain by Jerónimo-Santos, André, Henriques Vaz, Sandra Cristina, Parreira, Sara, Lerias, Sofia, Caetano, António P., Buée-Scherrer, Valérie, Castrén, Eero, Valente, Cláudia, Blum, David, Sebastião, Ana M, de Oliveira Diógenes Nogueira, Maria José

“…© The Author 2014. Published by Oxford University Press. All rights reserved. Brain-derived neurotrophic factor (BDNF) and its high-affinity full-length (FL)…”
Get full text

Editorial: Meeting of the Portuguese Society for Neurosciences SPN2019 by Diógenes, Maria José, Guimas Almeida, Cláudia, Xapelli, Sara

“…In a brief Research Report, Miranda et al. show that cannabidiol, Δ9-tetrahydrocannabinol, and two synthetic cannabinoids (THJ-018 and EG-018) profoundly…”
Get full text

S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5 by Ferreira, Catarina B., Marttinen, Mikael, Coelho, Joana E., Paldanius, Kaisa M.A., Takalo, Mari, Mäkinen, Petra, Leppänen, Luukas, Miranda-Lourenço, Catarina, Fonseca-Gomes, João, Tanqueiro, Sara R., Vaz, Sandra H., Belo, Rita F., Sebastião, Ana Maria, Leinonen, Ville, Soininen, Hilkka, Pike, Ian, Haapasalo, Annakaisa, Lopes, Luísa V., de Mendonça, Alexandre, Diógenes, Maria José, Hiltunen, Mikko

“…Alzheimer's disease (AD) is the most common form of dementia, which is neuropathologically characterized by extracellular senile plaques containing amyloid-β…”
Get full text

Controversies about the cardiovascular effects of OM3FA. Did inappropriate placebos skew clinical trial results? by do Vale, Fernando Martins, Diógenes, Maria José, Barbacena, Henrique Atalaia

“…•Several observational studies suggest that omega-3 fatty acids (OM3FA) may reduce cardiovascular risk.•OM3FA and olive oil have antiplatelet and…”
Get full text

From cannabinoids and neurosteroids to statins and the ketogenic diet: new therapeutic avenues in Rett syndrome? by Mouro, Francisco, Miranda Lourenço, Catarina, Sebastião, Ana M, de Oliveira Diógenes Nogueira, Maria José

“…Copyright © 2019 Mouro, Miranda-Lourenço, Sebastião and Diógenes. This is an open-access article distributed under the terms of the Creative Commons…”
Get full text

In vivo bio-distribution and toxicity evaluation of polymeric and lipid-based nanoparticles : a potential approach for chronic diseases treatment by Fonseca-Gomes, João, Loureiro, Joana A, Tanqueiro, Sara, Mouro, Francisco, Ruivo, Pedro, Carvalho, Tânia, Sebastião, Ana M, de Oliveira Diógenes Nogueira, Maria José, Pereira, Maria Carmo

“…© 2020 Fonseca-Gomes et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at…”
Get full text

Microglial Sirtuin 2 shapes long-term potentiation in hippocampal slices by Sa de Almeida, Joana, Vargas, Mariana, Fonseca-Gomes, João, Tanqueiro, Sara, Belo, Rita, Miranda Lourenço, Catarina, Sebastião, Ana M, de Oliveira Diógenes Nogueira, Maria José, Pais, Teresa F.

“…Copyright © 2020 Sa de Almeida, Vargas, Fonseca-Gomes, Tanqueiro, Belo, Miranda-Lourenço, Sebastião, Diógenes and Pais. This is an open-access article…”
Get full text

The neuroprotective action of amidated-kyotorphin on amyloid β peptide-induced Alzheimer’s disease pathophysiology by Belo, Rita, Martins, Margarida L. F., Shvachiy, Liana, Costa-Coelho, Tiago, De Almeida Borlido, Carolina, Fonseca-Gomes, João, Neves, Vera, Vicente Miranda, Hugo, Outeiro, Tiago F., Coelho, Joana, Xapelli, Sara, Valente, Cláudia, Heras, Montserrat, Bardaji, Eduard, Castanho, Miguel, de Oliveira Diógenes Nogueira, Maria José, Sebastião, Ana M

“…Copyright © 2020 Belo, Martins, Shvachiy, Costa-Coelho, de Almeida-Borlido, Fonseca-Gomes, Neves, Vicente Miranda, Outeiro, Coelho, Xapelli, Valente, Heras,…”
Get full text

Challenges and promises in the development of neurotrophic factor-based therapies for Parkinson’s disease by Rodrigues, Tiago M., Jerónimo-Santos, André, Outeiro, Tiago, Sebastião, Ana M, de Oliveira Diógenes Nogueira, Maria José

“…© Springer International Publishing Switzerland 2014 Parkinson's disease (PD) is a chronic movement disorder typically coupled to progressive degeneration of…”
Get full text

Neuroprotection afforded by adenosine A2A receptor blockade is modulated by corticotrophin-releasing factor (CRF) in glutamate injured cortical neurons by Valadas, Jorge S., Batalha, Vânia L., Ferreira, Diana G., Gomes, Rui, Coelho, Joana E., Sebastião, Ana M., Diógenes, Maria José, Lopes, Luísa V.

“…© 2012 International Society for Neurochemistry In situations of hypoxia, glutamate excitotoxicity induces neuronal death. The release of extracellular…”
Get full text

Enhanced LTP in aged rats: Detrimental or compensatory? by Pinho, Júlia, Vale, Ruben, Batalha, Vânia L., Costenla, Ana Rita, Dias, Raquel, Rombo, Diogo, Sebastião, Ana M., de Mendonça, Alexandre, Diógenes, Maria José

“…Age-dependent memory deterioration has been well documented and yet an increase in rat hippocampal LTP upon aging has been reported. This poses the question of…”
Get full text

Neurotrophic factors as a protective strategy in Parkinson's disease by Diógenes, Maria José, Outeiro, Tiago Fleming

“…Neurodegenerative disorders are devastating human diseases that include Parkinson's, Huntington's, Alzheimer's, amyotrophic lateral sclerosis, and the frontal…”
Get more information

Brain-derived neurotrophic factor mediates neuroprotection against Aβ-induced toxicity through a mechanism independent on adenosine 2A receptor activation by Jerónimo-Santos, André, Fonseca-Gomes, João, Guimarães, Diogo Andrade, Tanqueiro, Sara Ramalho, Ramalho, Rita Mira, Ribeiro, Joaquim Alexandre, Sebastião, Ana Maria, Diógenes, Maria José

“…Brain-derived neurotrophic factor (BDNF) promotes neuronal survival through TrkB-FL activation. The activation of adenosine A 2A receptors (A 2A R) is…”
Get full text

Brain-derived neurotrophic factor modulation in response to oxidative stress and corticosterone: role of scopolamine and mirtazapine by Correia, Ana Salomé, Torrado, Marília, Costa-Coelho, Tiago, Carvalho, Eva Daniela, Inteiro-Oliveira, Sara, Diógenes, Maria José, Pêgo, Ana Paula, Santos, Sofia Duque, Sebastião, Ana M., Vale, Nuno

“…Major Depressive Disorder (MDD) is a very complex disease, challenging to study and manage. The complexities of MDD require extensive research of its…”
Get full text

Selective modulation of epileptic tissue by an adenosine A3 receptor‐activating drug by Ghosh, Anwesha, Ribeiro‐Rodrigues, Leonor, Ruffolo, Gabriele, Alfano, Veronica, Domingos, Cátia, Rei, Nádia, Tosh, Dilip K., Rombo, Diogo M., Morais, Tatiana P., Valente, Cláudia A., Xapelli, Sara, Bordadágua, Beatriz, Rainha‐Campos, Alexandre, Bentes, Carla, Aronica, Eleonora, Diógenes, Maria José, Vaz, Sandra H., Ribeiro, Joaquim A., Palma, Eleonora, Jacobson, Kenneth A., Sebastião, Ana M.

“…Background and Purpose Adenosine, through the A1 receptor (A1R), is an endogenous anticonvulsant. The development of adenosine receptor agonists as antiseizure…”
Get full text

Cholesterol redistribution triggered by CYP46A1 gene therapy improves major hallmarks of Niemann-Pick type C disease but is not sufficient to halt neurodegeneration by Nunes, Maria João, Carvalho, Andreia Neves, Reis, Joana, Costa, Daniela, Moutinho, Miguel, Mateus, Joana, Mendes de Almeida, Rita, Brito, Sara, Risso, Daniela, Nunes, Sofia, Castro-Caldas, Margarida, Gama, Maria João, Rodrigues, Cecília M.P., Xapelli, Sara, Diógenes, Maria José, Cartier, Nathalie, Chali, Farah, Piguet, Françoise, Rodrigues, Elsa

“…Cholesterol 24-hydroxylase (CYP46A1) is an exclusively neuronal cytochrome P450 enzyme responsible for converting cholesterol into 24S-hydroxycholesterol,…”
Get full text