Search Results - "Diodato, E."
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Presenilin-1 Regulates the Neuronal Threshold to Excitotoxicity Both Physiologically and Pathologically
Published in Proceedings of the National Academy of Sciences - PNAS (07-11-2000)“…A direct pathophysiological role of Familial Alzheimer's Disease (FAD)-associated Presenilin 1 (PS1) mutations in neuronal vulnerability remains a…”
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An exploratory double‐blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease
Published in British journal of clinical pharmacology (01-03-2015)“…Aims Selisistat, a selective SirT1 inhibitor is being developed as a potentially disease‐modifying therapeutic for Huntington's disease (HD). This was the…”
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Promoting Tourism Education in MENA Countries: Geopolitical Implications
Published in Almatourism (Rimini) (01-10-2014)“…Tourism development across the Middle East and North Africa is mostly based on low cost and mass beach leisure. This kind of tourism development generated,…”
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F02 Selisistat: soluble HTT protein levels as a potential pharmacodynamic readout
Published in Journal of neurology, neurosurgery and psychiatry (01-09-2012)“…BackgroundSiena Biotech SpA is developing selisistat (SEN0014196) as a potentially disease-modifying therapy for HD. Selsistat is a potent and selective SirT1…”
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F02Selisistat: soluble HTT protein levels as a potential pharmacodynamic readout
Published in Journal of neurology, neurosurgery and psychiatry (01-09-2012)“…BackgroundSiena Biotech SpA is developing selisistat (SEN0014196) as a potentially disease-modifying therapy for HD. Selsistat is a potent and selective SirT1…”
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Detection of phosphorylation patterns in rat cortical neurons by combining phosphatase treatment and DIGE technology
Published in Proteomics (Weinheim) (01-02-2006)“…Although protein phosphorylation is probably the most studied post‐translational modification occurring in cells, the number of proteins, which are the target…”
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Ecdysone-based system for controlled inducible expression of metabotropic glutamate receptor subtypes 2, 5, and 8
Published in Journal of biomolecular screening (01-12-2005)“…Stable and inducible expression of human metabotropic glutamate receptor types 2, 5, and 8 was achieved in HEK293 cells using the ecdysone inducible system…”
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