Search Results - "Dinning, Phil G."

Understanding the physiology of human defaecation and disorders of continence and evacuation by Heitmann, Paul T., Vollebregt, Paul F., Knowles, Charles H., Lunniss, Peter J., Dinning, Phil G., Scott, S. Mark

“…The act of defaecation, although a ubiquitous human experience, requires the coordinated actions of the anorectum and colon, pelvic floor musculature, and the…”
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Postoperative ileus: mechanisms and future directions for research by Vather, Ryash, O'Grady, Greg, Bissett, Ian P, Dinning, Phil G

“…Summary Postoperative ileus (POI) is an abnormal pattern of gastrointestinal motility characterized by nausea, vomiting, abdominal distension and/or delayed…”
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Postoperative ileus—An ongoing conundrum by Wattchow, David, Heitmann, Paul, Smolilo, David, Spencer, Nick J., Parker, Dominic, Hibberd, Timothy, Brookes, Simon S. J., Dinning, Phil G., Costa, Marcello

“…Background Postoperative ileus is common and is a major clinical problem. It has been widely studied in patients and in experimental models in laboratory…”
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From the organ bath to the whole person: a review of human colonic motility by Wattchow, David A, Brookes, Simon J, Spencer, Nick J, Heitmann, Paul T, De Giorgio, Roberto, Costa, Marcello, Dinning, Phil G

“…Motor function of the colon is essential for health. Our current understanding of the mechanisms that underlie colonic motility are based upon a range of…”
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The “rectosigmoid brake”: Review of an emerging neuromodulation target for colorectal functional disorders by Lin, Anthony Y, Dinning, Phil G, Milne, Tony, Bissett, Ian P, O'Grady, Gregory

“…Summary The regulation of gastrointestinal motility encompasses several overlapping mechanisms including highly regulated and coordinated neurohormonal…”
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Circadian rhythms in colonic function by Hibberd, Timothy J, Ramsay, Stewart, Spencer-Merris, Phaedra, Dinning, Phil G, Zagorodnyuk, Vladimir P, Spencer, Nick J

“…A rhythmic expression of clock genes occurs within the cells of multiple organs and tissues throughout the body, termed "peripheral clocks." Peripheral clocks…”
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Roles of three distinct neurogenic motor patterns during pellet propulsion in guinea‐pig distal colon by Costa, Marcello, Keightley, Lauren J., Wiklendt, Lukasz, Hibberd, Timothy J., Arkwright, John W., Omari, Taher, Wattchow, David A., Zagorodnyuk, Vladimir, Brookes, Simon J. H., Dinning, Phil G., Spencer, Nick J.

“…Key points Enteric neural circuits enable isolated preparations of guinea‐pig distal colon to propel solid and fluid contents by a self‐sustaining…”
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Sympathetic Pathways Target Cholinergic Neurons in the Human Colonic Myenteric Plexus by Parker, Dominic R, Wiklendt, Lukasz, Humenick, Adam, Chen, Bao Nan, Sia, Tiong Cheng, Wattchow, David A, Dinning, Phil G, Brookes, Simon J H

“…The sympathetic nervous system inhibits human colonic motility largely by effects on enteric neurons. Noradrenergic axons, which branch extensively in the…”
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Automated Analysis Using a Bayesian Functional Mixed-Effects Model With Gaussian Process Responses for Wavelet Spectra of Spatiotemporal Colonic Manometry Signals by Wiklendt, Lukasz, Costa, Marcello, Scott, Mark S, Brookes, Simon J H, Dinning, Phil G

“…Manual analysis of human high-resolution colonic manometry data is time consuming, non-standardized and subject to laboratory bias. In this article we present…”
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Characterization of viscerofugal neurons in human colon by retrograde tracing and multi-layer immunohistochemistry by Chen, Bao Nan, Humenick, Adam G, Hibberd, Timothy James, Yew, Wai Ping, Wattchow, David A, Dinning, Phil G, Costa, Marcello, Spencer, Nick J, Brookes, Simon J H

“…Viscerofugal neurons (VFNs) have cell bodies in the myenteric plexus and axons that project to sympathetic prevertebral ganglia. In animals they activate…”
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Characterisation of parasympathetic ascending nerves in human colon by Johnson, Michaela E, Humenick, Adam, Peterson, Rochelle A, Costa, Marcello, Wattchow, David A, Sia, Tiong Cheng, Dinning, Phil G, Brookes, Simon J H

“…In the human large bowel, sacral parasympathetic nerves arise from S2 to S4, project to the pelvic plexus ("hypogastric plexus") and have post-ganglionic axons…”
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Characterization of projections of longitudinal muscle motor neurons in human colon by Humenick, Adam, Chen, Bao Nan, Lauder, Chris I. W., Wattchow, David A., Zagorodnyuk, Vladimir P., Dinning, Phil G., Spencer, Nick J., Costa, Marcello, Brookes, Simon J. H.

“…Background The enteric nervous system contains inhibitory and excitatory motor neurons which modulate smooth muscle contractility. Cell bodies of longitudinal…”
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Coexistent faecal incontinence and constipation: A cross-sectional study of 4027 adults undergoing specialist assessment by Vollebregt, Paul F., Wiklendt, Lukasz, Dinning, Phil G, Knowles, Charles H., Scott, S.Mark

“…In contrast to paediatric and geriatric populations, faecal incontinence and constipation in adults are generally considered separate entities. This may be…”
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A Novel Method for Electrophysiological Analysis of EMG Signals Using MesaClip by Wiklendt, Lukasz, Brookes, Simon J. H., Costa, Marcello, Travis, Lee, Spencer, Nick J., Dinning, Phil G.

“…In electrophysiology, many methods have been proposed for the analysis of action potential firing frequencies. The aim of this study was to present an…”
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Neural mechanisms of peristalsis in the isolated rabbit distal colon: a neuromechanical loop hypothesis by Dinning, Phil G, Wiklendt, Lukasz, Omari, Taher, Arkwright, John W, Spencer, Nick J, Brookes, Simon J H, Costa, Marcello

“…Propulsive contractions of circular muscle are largely responsible for the movements of content along the digestive tract. Mechanical and electrophysiological…”
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Treatment of irritable bowel syndrome with diarrhoea using titrated ondansetron (TRITON): study protocol for a randomised controlled trial by Gunn, David, Fried, Ron, Lalani, Rabia, Farrin, Amanda, Holloway, Ivana, Morris, Tom, Olivier, Catherine, Kearns, Rachael, Corsetti, Maura, Scott, Mark, Farmer, Adam, Emmanuel, Anton, Whorwell, Peter, Yiannakou, Yan, Sanders, David, Mclaughlin, John, Kapur, Kapil, Eugenicos, Maria, Akbar, Ayesha, Trudgill, Nigel, Houghton, Lesley, Dinning, Phil G, Ford, Alexander C, Aziz, Qasim, Spiller, Robin

“…Irritable bowel syndrome with diarrhoea (IBS-D) affects up to 4% of the general population. Symptoms include frequent, loose, or watery stools with associated…”
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Stimulation of extrinsic sympathetic nerves differentially affects neurogenic motor activity in guinea pig distal colon by Smolilo, David J., Hibberd, Timothy J., Costa, Marcello, Dinning, Phil G., Keightley, Lauren J., De Fontgalland, Dayan, Wattchow, David A., Spencer, Nick J.

“…The speed of pellet propulsion through the isolated guinea pig distal colon in vitro significantly exceeds in vivo measurements, suggesting a role for…”
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Manometry of the Human Ileum and Ileocaecal Junction in Health, Disease and Surgery: A Systematic Review by Liu, Chen, Saw, Kai Sheng, Dinning, Phil G, O'Grady, Gregory, Bissett, Ian

“…The terminal ileum and ileocaecal junction form a transition zone in a relatively inaccessible portion of the gastrointestinal tract. Little is known about the…”
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Potential causes of the preoperative increase in the rectosigmoid cyclic motor pattern: A high‐resolution manometry study by Wells, Cameron I., Bhat, Sameer, Paskaranandavadivel, Nira, Lin, Anthony Y., Vather, Ryash, Varghese, Chris, Penfold, James A., Rowbotham, David, Dinning, Phil G., Bissett, Ian P., O’Grady, Greg

“…Background Cyclic motor patterns (CMPs) are the most common motor pattern in the distal colon. This study used high‐resolution (HR) colonic manometry to…”
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Insights into the mechanisms underlying colonic motor patterns by Spencer, Nick J., Dinning, Phil G., Brookes, Simon J., Costa, Marcello

“…In recent years there have been significant technical and methodological advances in our ability to record the movements of the gastrointestinal tract. This…”
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