Search Results - "Dinning, P. G."

A new understanding of the physiology and pathophysiology of colonic motility? by Dinning, P. G.

“…Background In recent years, high‐resolution manometry has been used in an attempt to gain a greater insight into the physiology/pathophysiology of colonic…”
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Quantification of in vivo colonic motor patterns in healthy humans before and after a meal revealed by high‐resolution fiber‐optic manometry by Dinning, P. G., Wiklendt, L., Maslen, L., Gibbins, I., Patton, V., Arkwright, J. W., Lubowski, D. Z., O'Grady, G., Bampton, P. A., Brookes, S. J., Costa, M.

“…Background Until recently, investigations of the normal patterns of motility of the healthy human colon have been limited by the resolution of in vivo…”
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The effect of sacral nerve stimulation on distal colonic motility in patients with faecal incontinence by Patton, V., Wiklendt, L., Arkwright, J. W., Lubowski, D. Z., Dinning, P. G.

“…Background Sacral nerve stimulation (SNS) is an effective treatment for neurogenic faecal incontinence (FI). However, the clinical improvement that patients…”
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Hyperactive cyclic motor activity in the distal colon after colonic surgery as defined by high‐resolution colonic manometry by Vather, R., O'Grady, G., Lin, A. Y., Du, P., Wells, C. I., Rowbotham, D., Arkwright, J., Cheng, L. K., Dinning, P. G., Bissett, I. P.

“…Background Recovery after colonic surgery is invariably delayed by disturbed gut motility. It is commonly assumed that colonic motility becomes quiescent after…”
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Neurogenic and myogenic motor activity in the colon of the guinea pig, mouse, rabbit, and rat by Costa, M, Dodds, K N, Wiklendt, L, Spencer, N J, Brookes, S J H, Dinning, P G

“…Gastrointestinal motility involves interactions between myogenic and neurogenic processes intrinsic to the gut wall. We have compared the presence of…”
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Neuromechanical factors involved in the formation and propulsion of fecal pellets in the guinea‐pig colon by Costa, M., Wiklendt, L., Simpson, P., Spencer, N. J., Brookes, S. J., Dinning, P. G.

“…Background The neuromechanical processes involved in the formation and propulsion of fecal pellets remain incompletely understood. Methods We analyzed motor…”
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Author's reply: The effect of sacral nerve stimulation on distal colonic motility in patients with faecal incontinence (Br J Surg 2013; 100: 959-968) by Dinning, P. G.

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Restoration of normal colonic motor patterns and meal responses after distal colorectal resection by Vather, R., O'Grady, G., Arkwright, J. W., Rowbotham, D. S., Cheng, L. K., Dinning, P. G., Bissett, I. P.

“…Background Colorectal resections alter colonic motility, including disruption of control by neural or bioelectrical cell networks. The long‐term impact of…”
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Relationships between the results of anorectal investigations and symptom severity in patients with faecal incontinence by Heitmann, P. T., Rabbitt, P., Schloithe, A., Patton, V., Skuza, P. P., Wattchow, D. A., Dinning, P. G.

“…Purpose Anorectal dysfunction is the focus of diagnostic investigations for faecal incontinence. However, severity of incontinence and anorectal investigation…”
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Pancolonic motor response to subsensory and suprasensory sacral nerve stimulation in patients with slow-transit constipation by Dinning, P. G., Hunt, L. M., Arkwright, J. W., Patton, V., Szczesniak, M. M., Wiklendt, L., Davidson, J. B., Lubowski, D. Z., Cook, I. J.

“…Background: Sacral nerve stimulation (SNS) is emerging as a potential treatment for patients with constipation. Although SNS can elicit an increase in colonic…”
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Neuroanatomy and physiology of colorectal function and defaecation: from basic science to human clinical studies by Brookes, S. J., Dinning, P. G., Gladman, M. A.

“…Colorectal physiology is complex and involves programmed, coordinated interaction between muscular and neuronal elements. Whilst a detailed understanding…”
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The proximal colonic motor response to rectal mechanical and chemical stimulation by Bampton, P A, Dinning, P G, Kennedy, M L, Lubowski, D Z, Cook, I J

“…We aimed to determine whether rectal distension and/or infusion of bile acids stimulates propagating or nonpropagating activity in the unprepared proximal…”
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Ascending excitatory neural pathways modulate slow phasic myogenic contractions in the isolated human colon by Carbone, S. E., Dinning, P. G., Costa, M., Spencer, N. J., Brookes, S. J. H., Wattchow, D. A.

“…Background In animal models, enteric reflex pathways have potent effects on motor activity; their roles have been much less extensively studied in human gut…”
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Classification of normal and abnormal colonic motility based on cross‐correlations of pancolonic manometry data by Wiklendt, L., Mohammed, S. D., Scott, S. M., Dinning, P. G.

“…Background  Manual analysis of data acquired from manometric studies of colonic motility is laborious, subject to laboratory bias and not specific enough to…”
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Novel diagnostics and therapy of colonic motor disorders by Dinning, PG, Scott, SM

“…Highlights ► Colonic motor disorders can be difficult to diagnose and treat. ► Several recent novel diagnostic tool have been developed to help record and…”
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High Resolution Colonic Manometry – What Have We Learnt?- a Review of the Literature 2012 by Bampton, P. A., Dinning, P. G.

“…Despite its size and physiological importance, the human colon is one of the least understood organs of the body. Many disorders arise from suspected…”
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The effect of luminal content and rate of occlusion on the interpretation of colonic manometry by Arkwright, J. W., Dickson, A., Maunder, S. A., Blenman, N. G., Lim, J., O’Grady, G., Archer, R., Costa, M., Spencer, N. J., Brookes, S., Pullan, A., Dinning, P. G.

“…Background  Manometry is commonly used for diagnosis of esophageal and anorectal motility disorders. In the colon, manometry is a useful tool, but clinical…”
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A systematic review of sacral nerve stimulation mechanisms in the treatment of fecal incontinence and constipation by Carrington, E. V., Evers, J., Grossi, U., Dinning, P. G., Scott, S. M., O'Connell, P. R., Jones, J. F. X., Knowles, C. H.

“…Background Sacral nerve stimulation (SNS) is now well established as a treatment for fecal incontinence (FI) resistant to conservative measures and may also…”
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Anatomical registration and three‐dimensional visualization of low and high‐resolution pan‐colonic manometry recordings by Davidson, J. B., O’Grady, G., Arkwright, J. W., Zarate, N., Scott, S. M., Pullan, A. J., Dinning, P. G.

“…Background  Colonic propagating sequences (PS) are important for the movement of colonic content and defecation, and aberrant PS patterning has been associated…”
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Colonic motor abnormalities in slow transit constipation defined by high resolution, fibre‐optic manometry by Dinning, P. G., Wiklendt, L., Maslen, L., Patton, V., Lewis, H., Arkwright, J. W., Wattchow, D. A., Lubowski, D. Z., Costa, M., Bampton, P. A.

“…Background Slow transit constipation (STC) is associated with colonic motor abnormalities. The underlying cause(s) of the abnormalities remain poorly defined…”
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