Search Results - "Dinman, J D"

The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling by Girardi, T, Vereecke, S, Sulima, S O, Khan, Y, Fancello, L, Briggs, J W, Schwab, C, de Beeck, J Op, Verbeeck, J, Royaert, J, Geerdens, E, Vicente, C, Bornschein, S, Harrison, C J, Meijerink, J P, Cools, J, Dinman, J D, Kampen, K R, De Keersmaecker, K

“…Several somatic ribosome defects have recently been discovered in cancer, yet their oncogenic mechanisms remain poorly understood. Here we investigated the…”
Get full text

A-1 ribosomal frameshift in a double-stranded RNA virus of yeast forms a gag-pol fusion protein by Dinman, J.D. (National Institute of Health, Bethesda, MD), Icho, T, Wickner, R.B

“…The L-A double-stranded RNA (dsRNA) virus of Saccharomyces cerevisiae has two open reading frames (ORFs). ORF1 encodes the 80-kDa major coat protein (gag)…”
Get full text

Ribosomal frameshifting efficiency and gag/gag-pol ratio are critical for yeast M1 double-stranded RNA virus propagation by Dinman, J.D. (National Institutes of Diabetes, Digestive and Kidney Disease, Bethesda, MD), Wickner, R.B

“…About 1.9% of ribosomes translating the gag open reading frame of the yeast L-A double-stranded RNA virus positive strand undergo a -1 frameshift and continue…”
Get full text

Mof4-1 is an allele of the UPF1/IFS2 gene which affects both mRNA turnover and -1 ribosomal frameshifting efficiency by Cui, Y, Dinman, J.D, Peltz, S.W

“…The mof4-1 (maintenance of frame) allele in the yeast Saccharomyces cerevisiae was isolated as a chromosomal mutation that increased the efficiency of -1…”
Get full text

Saturation Mutagenesis of 5S rRNA in Saccharomyces cerevisiae by Smith, Maria W., Meskauskas, Arturas, Wang, Pinger, Sergiev, Petr V., Dinman, Jonathan D.

“…rRNAs are the central players in the reactions catalyzed by ribosomes, and the individual rRNAs are actively involved in different ribosome functions. Our…”
Get full text

rRNA mutants in the yeast peptidyltransferase center reveal allosteric information networks and mechanisms of drug resistance by Rakauskaitė, Rasa, Dinman, Jonathan D

“…To ensure accurate and rapid protein synthesis, nearby and distantly located functional regions of the ribosome must dynamically communicate and coordinate…”
Get full text

Translating old drugs into new treatments: ribosomal frameshifting as a target for antiviral agents by Dinman, Jonathan D, Ruiz-Echevarria, Maria J, Peltz, Stuart W

“…Programmed ribosomal frameshifting is used by many viruses to regulate the production of structural and enzymatic proteins. Altering the frameshifting…”
Get full text

Translational maintenance of frame: mutants of Saccharomyces cerevisiae with altered -1 ribosomal frameshifting efficiencies by Dinman, J D, Wickner, R B

“…A special site on the (+) strand of the L-A dsRNA virus induces about 2% of ribosomes translating the gag open reading frame to execute a -1 frameshift and…”
Get full text

Spermidine deficiency increases +1 ribosomal frameshifting efficiency and inhibits Ty1 retrotransposition in Saccharomyces cerevisiae by Balasundaram, D, Dinman, J.D, Wickner, R.B, Tabor, C.W, Tabor, H

“…Polyamines have been implicated in nucleic acid-related functions and in protein biosynthesis. RNA sequences that specifically direct ribosomes to shift…”
Get full text

Yeast MAK3 N-acetyltransferase recognizes the N-terminal four amino acids of the major coat protein (gag) of the L-A double-stranded RNA virus by Tercero, J.C. (Pharmagen, Madrid, Spain), Dinman, J.D, Wickner, R.B

“…The MAK3 gene of Saccharomyces cerevisiae encodes an N-acetyltransferase whose acetylation of the N terminus of the L-A double-stranded RNA virus major coat…”
Get full text

5 S rRNA is involved in fidelity of translational reading frame by Dinman, J.D. (National Institutes of Health, Bethesda, MD.), Wickner, R.B

“…Chromosomal mutants (maintenance of frame = mof) in which the efficiency of -1 ribosomal frame-shifting is increased can be isolated using constructs in which…”
Get full text

SPE1 and SPE2: two essential genes in the biosynthesis of polyamines that modulate +1 ribosomal frameshifting in Saccharomyces cerevisiae by Balasundaram, D. (National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.), Dinman, J.D, Tabor, C.W, Tabor, H

“…We previously showed that a mutant of Saccharomyces cerevisiae, which cannot make spermidine as a result of a deletion in the SPE2 gene (spe2-delta), exhibits…”
Get full text

An ‘integrated model’ of programmed ribosomal frameshifting by Harger, Jason W, Meskauskas, Arturas, Dinman, Jonathan D

“…Many viral mRNAs, including those of HIV-1, can make translating ribosomes change reading frame. Altering the efficiencies of programmed ribosomal frameshift…”
Get full text

Kinetics of Ribosomal Pausing during Programmed −1 Translational Frameshifting by Lopinski, John D., Dinman, Jonathan D., Bruenn, Jeremy A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Ribosomal protein L5 helps anchor peptidyl-tRNA to the P-site in Saccharomyces cerevisiae by MESKAUSKAS, ARTURAS, DINMAN, JONATHAN D.

“…Our previous demonstration that mutants of 5S rRNA called mof9 can specifically alter efficiencies of programmed ribosomal frameshifting (PRF) suggested a role…”
Get full text

The Frameshift Signal of HIV-1 Involves a Potential Intramolecular Triplex RNA Structure by Dinman, Jonathan D., Richter, Sara, Plant, Ewan P., Taylor, Ronald C., Hammell, Amy B., Rana, Tariq M.

“…The cis-acting mRNA elements that promote programmed -1 ribosomal frameshifting present a natural target for the rational design of antiretroviral…”
Get full text

A programmed –1 ribosomal frameshift signal can function as a cis‐acting mRNA destabilizing element by Plant, Ewan P., Wang, Pinger, Jacobs, Jonathan L., Dinman, Jonathan D.

“…Nonsense‐mediated mRNA decay (NMD) directs rapid degradation of premature termination codon (PTC)‐containing mRNAs, e.g. those containing frameshift mutations…”
Get full text

Translational misreading: Mutations in translation elongation factor 1 alpha differentially affect programmed ribosomal frameshifting and drug sensitivity by Dinman, J D, Kinzy, T G

“…The translation elongation factor 1 alpha (EF-1 alpha ) catalyzes the critical step of delivering aminoacyl-tRNAs to the elongating ribosome. A series of…”
Get full text

Decreased peptidyltransferase activity correlates with increased programmed -1 ribosomal frameshifting and viral maintenance defects in the yeast Saccharomyces cerevisiae by Meskauskas, Arturas, Harger, Jason W, Jacobs, Kristi L Muldoon, Dinman, Jonathan D

“…Increased efficiencies of programmed -1 ribosomal frameshifting in yeast cells expressing mutant forms of ribosomal protein L3 are unable to maintain the dsRNA…”
Get full text

New Targets for Antivirals: The Ribosomal A-Site and the Factors That Interact with It by Goss Kinzy, Terri, Harger, Jason W., Carr-Schmid, Anne, Kwon, Jane, Shastry, Mythili, Justice, Michael, Dinman, Jonathan D.

“…Many viruses use programmed −1 ribosomal frameshifting to ensure the correct ratio of viral structural to enzymatic proteins. Alteration of frameshift…”
Get full text