Hypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registry

•This study analyzed 526 patients with COVID-19 with hypothyroidism and 526 controls.•Patients with hypothyroidism required less intensive care interventions.•Patients with hypothyroidism showed a trend of lower in-hospital mortality.•Hypothyroidism does not seem to be associated with a worse progno...

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Published in:	International journal of infectious diseases Vol. 116; pp. 319 - 327
Main Authors:	Pereira, Daniella Nunes, Silveira, Leticia Ferreira Gontijo, Guimarães, Milena Maria Moreira, Polanczyk, Carísi Anne, Nunes, Aline Gabrielle Sousa, Costa, André Soares de Moura, Farace, Barbara Lopes, Cimini, Christiane Corrêa Rodrigues, Carvalho, Cíntia Alcantara de, Ponce, Daniela, Roesch, Eliane Würdig, Manenti, Euler Roberto Fernandes, Lucas, Fernanda Barbosa, Rodrigues, Fernanda d'Athayde, Anschau, Fernando, Aranha, Fernando Graça, Bartolazzi, Frederico, Vietta, Giovanna Grunewald, Nascimento, Guilherme Fagundes, Duani, Helena, Vianna, Heloisa Reniers, Guimarães, Henrique Cerqueira, Costa, Jamille Hemétrio Salles Martins, Batista, Joanna d'Arc Lyra, Alvarenga, Joice Coutinho de, Chatkin, José Miguel, Morais, Júlia Drumond Parreiras de, Machado-Rugolo, Juliana, Ruschel, Karen Brasil, Pinheiro, Lílian Santos, Menezes, Luanna Silva Monteiro, Couto, Luciana Siuves Ferreira, Kopittke, Luciane, Castro, Luís César de, Nasi, Luiz Antônio, Cabral, Máderson Alvares de Souza, Floriani, Maiara Anschau, Souza, Maíra Dias, Carneiro, Marcelo, Bicalho, Maria Aparecida Camargos, Godoy, Mariana Frizzo de, Nogueira, Matheus Carvalho Alves, Guimarães Júnior, Milton Henriques, Sampaio, Natália da Cunha Severino, Oliveira, Neimy Ramos de, Assaf, Pedro Ledic, Finger, Renan Goulart, Campos, Roberta Xavier, Menezes, Rochele Mosmann, Francisco, Saionara Cristina, Alvarenga, Samuel Penchel, Guimarães, Silvana Mangeon Mereilles, Araújo, Silvia Ferreira, Oliveira, Talita Fischer, Diniz, Thulio Henrique Oliveira, Ramires, Yuri Carlotto, Cenci, Evelin Paola de Almeida, Oliveira, Thainara Conceição de, Schwarzbold, Alexandre Vargas, Ziegelmann, Patricia Klarmann, Pozza, Roberta, Carvalho, Caroline Scherer, Pires, Magda Carvalho, Marcolino, Milena Soriano
Format:	Journal Article
Language:	English
Published:	Canada Elsevier Ltd 01-03-2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases Elsevier
Subjects:	Aged COVID-19 COVID-19 Testing Epidemiology Female Hospital Mortality Humans Hypothyroidism Hypothyroidism - complications Hypothyroidism - epidemiology Mortality Prognosis Registries SARS-CoV-2 COVID-19 Prognosis Hypothyroidism Epidemiology Mortality
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Summary:	•This study analyzed 526 patients with COVID-19 with hypothyroidism and 526 controls.•Patients with hypothyroidism required less intensive care interventions.•Patients with hypothyroidism showed a trend of lower in-hospital mortality.•Hypothyroidism does not seem to be associated with a worse prognosis in COVID-19. It is not clear whether previous thyroid diseases influence the course and outcomes of COVID-19. The study is a part of a multicentric cohort of patients with confirmed COVID-19 diagnosis from 37 hospitals. Matching for age, sex, number of comorbidities, and hospital was performed for the paired analysis. Of 7,762 patients with COVID-19, 526 had previously diagnosed hypothyroidism and 526 were matched controls. The median age was 70 years, and 68.3% were females. The prevalence of comorbidities was similar, except for coronary and chronic kidney diseases that were higher in the hypothyroidism group (p=0.015 and p=0.001). D-dimer levels were lower in patients with hypothyroid (p=0.037). In-hospital management was similar, but hospital length-of-stay (p=0.029) and mechanical ventilation requirement (p=0.006) were lower for patients with hypothyroidism. There was a trend of lower in-hospital mortality in patients with hypothyroidism (22.1% vs 27.0%; p=0.062). Patients with hypothyroidism had a lower requirement of mechanical ventilation and showed a trend of lower in-hospital mortality. Therefore, hypothyroidism does not seem to be associated with a worse prognosis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1201-9712 1878-3511
DOI:	10.1016/j.ijid.2022.01.016