Search Results - "Diniz, Luan F"

Reducing the Hygroscopicity of the Anti-Tuberculosis Drug (S,S)‑Ethambutol Using Multicomponent Crystal Forms by Diniz, Luan F, Carvalho, Paulo S, de Melo, Cristiane C, Ellena, Javier

“…Ethambutol (ETB) is a chiral dibasic compound formulated and marketed as the (S,S)-ethambutol dihydrochloride, (S,S)-EDH, to treat tuberculosis. It is…”
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Synthesis and Crystalline Structure of Zinc Complexes with Antihypertensive Drug Lisinopril by Diniz, Renata, Franco, Chris H. J., Diniz, Luan F., de Souza, Márcia C.

“…The structural investigation of Zn2+ complexes with the ligand lisinopril (LIS), an inhibitor of angiotensin-converting enzyme (ACE), was performed. The main…”
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Highly Soluble Dacarbazine Multicomponent Crystals Less Prone to Photodegradation by Diniz, Luan F., Carvalho, Paulo S., Souza, Mateus A. C., Diniz, Renata, Fernandes, Christian

“…Dacarbazine (DTIC) is a widely prescribed oncolytic agent to treat advanced malignant melanomas. Nevertheless, the drug is known for exhibiting low and…”
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Enhancing the solubility and permeability of the diuretic drug furosemide via multicomponent crystal forms by Diniz, Luan F., Carvalho, Paulo S., Pena, Sarah A.C., Gonçalves, José E., Souza, Mateus A.C., de Souza Filho, José D., Bomfim Filho, Lucius F.O., Franco, Chris H.J., Diniz, Renata, Fernandes, Christian

“…[Display omitted] •Two multicomponent crystal forms of furosemide were prepared and elucidated.•A solid-state study was performed to correlate with…”
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Mechanochemical Synthesis of a Multicomponent Solid Form: The Case of 5‑Fluorocytosine Isoniazid Codrug by Souza, Matheus S, Diniz, Luan F, Vogt, Lautaro, Carvalho Jr, Paulo S, D’vries, Richard F, Ellena, Javier

“…Mechanochemistry synthesis was applied to the supramolecular synthesis and green scale-up production of a 1:1 drug–drug cocrystal involving the antimetabolite…”
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Fluconazole: Synthesis and Structural Characterization of Four New Pharmaceutical Cocrystal Forms by Dayo Owoyemi, Bolaji C, da Silva, Cecilia C. P, Souza, Matheus S, Diniz, Luan F, Ellena, Javier, Carneiro, Renato L

“…Pharmaceutical cocrystals have emerged over the past several decades as an alternative path for synthesizing stable and/or improved crystalline forms of active…”
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Racemic Salts and Solid Solutions of Enantiomers of the Antihypertensive Drug Carvedilol by Diniz, Luan F, Carvalho, Paulo S, da Nova Mussel, Wagner, Yoshida, Maria Irene, Diniz, Renata, Fernandes, Christian

“…The R and S enantiomers of the antihypertensive drug carvedilol (CVD) can display remarkable miscibility in the crystalline state allowing this active…”
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Multicomponent ionic crystals of diltiazem with dicarboxylic acids toward understanding the structural aspects driving the drug-release by Diniz, Luan F., Franco, Chris H.J., Silva, Daniely F., Martins, Larissa S., Carvalho Jr, Paulo S., Souza, Mateus A.C., Reis, Naialy F.A., Fernandes, Christian, Diniz, Renata

“…[Display omitted] •Three multicomponent crystal forms of diltiazem were designed, and their crystal structures elucidated.•Structural and energetic aspects was…”
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Kinetics, mechanism, and tautomerism in ametryn acid hydrolysis: From molecular structure to environmental impacts by Ramos, Bruno, Vaz, Wesley F., Diniz, Luan F., Sanches Neto, Flavio O., Ribeiro, Julio C.O., Carvalho-Silva, Valter H., Teixeira, Antonio Carlos S.C., Ribeiro, Caue, Napolitano, Hamilton B., Carvalho, Paulo S.

“…The excessive use of pesticides and the demand for environmentally friendly compounds have driven the focus to detailed studies of the environmental…”
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Amino–Imino Tautomerism in the Salt Formation of Albendazole: Hydrobromide and Nitrate Salts by Carvalho, Paulo de S, Diniz, Luan F, da Silva, Gelson T. S. T, Coutinho, Nayara Dantas, dos Santos, Priscila Gomes, Carvalho-Silva, Valter Henrique, Ribeiro, Caue, Ellena, Javier

“…Albendazole (ABZ) is a poorly soluble anthelmintic drug that can exist in amine and imine desmotropic forms. These facts can affect the solubility and…”
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Paroxetine and Fluoxetine Hexafluorosilicate salts: Synthesis, crystal structure, Hirshfeld surface, and supramolecular analysis by Carvalho-Jr, Paulo S., da Silva, Cecilia C.P., Diniz, Luan F., Souza, Matheus S., Tenorio, Juan C., Ellena, Javier

“…[Display omitted] •Synthesis and structure analyses of hexafluorosilicate salts of Paroxetine and Fluoxetine.•Supramolecular motif formed by the association of…”
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Pharmaceutical Salts of Carvedilol with Increased Solubility as an Approach for Enhancing the Drug Action by Pereira, Jose Antonio, Diniz, Luan F., W. Lehmann, Christian, Carvalho, Paulo S.

“…Carvedilol (CVD) is a β-blocker antihypertensive drug commonly used to treat cardiovascular disorders. Since the poor oral bioavailability of CVD can be…”
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Novel Isoniazid cocrystals with aromatic carboxylic acids: Crystal engineering, spectroscopy and thermochemical investigations by Diniz, Luan F., Souza, Matheus S., Carvalho, Paulo S., da Silva, Cecilia C.P., D'Vries, Richard F., Ellena, Javier

“…Four novel cocrystals of the anti-tuberculosis drug Isoniazid (INH), including two polymorphs, with the aromatic carboxylic acids p-nitrobenzoic (PNBA),…”
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Modulating the water solubility and thermal stability of the anti-tuberculosis drug Isoniazid via multicomponent crystal formation by Diniz, Luan F., Souza, Matheus S., Carvalho, Paulo S., Correa, Charlane C., Ellena, Javier

“…In this paper three novel salts of the anti-tuberculosis drug Isoniazid (INH) with the GRAS salt formers (oxalic, maleic and methanesulfonic acids) were…”
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Spontaneous Resolution of RS-Fluoxetine to a Racemic Conglomerate upon Salt Formation with Oxalic Acid by Carvalho, Paulo de Sousa, Diniz, Luan F., Cardoso, Teófilo Fernando Mazon, da Silva, Cecilia C. P., Ellena, Javier

“…Fluoxetine (Flx), an important active pharmaceutical ingredient (API) for the treatment of depression, is commercially available as a racemic hydrochloride…”
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Synthesis, characterization and solubility of a new anthelmintic salt: Mebendazole nitrate by Gutiérrez, Eduardo L., Souza, Matheus S., Diniz, Luan F., Ellena, Javier

“…Salt formation approach was taken to improve Mebendazole (MBZ) solubility. MBZ polymorph A was easily recrystallized as a 1:1 nitrate salt (MBZ N) in methanol…”
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Development of a salt drug with improved solubility: Ethionamide nitrate by Diniz, Luan F., Carvalho, Paulo S., de Melo, Cristiane C., Ellena, Javier

“…To avoid drug resistance, an adequate tuberculosis treatment should include not only a first-line drug but also at least one second-line drug such as, for…”
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EVOLUÇÃO DA LEGISLAÇÃO E DAS TÉCNICAS ANALÍTICAS APLICADAS A ESTUDOS DE ESTABILIDADE DE INSUMOS E PRODUTOS FARMACÊUTICOS by Facci, Julia, Diniz, Luan, Reis, Naialy, Fernandes, Christian

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5-Fluorocytosine/5-Fluorouracil Drug-Drug Cocrystal: a New Development Route Based on Mechanochemical Synthesis by da Silva, Cecilia C. P., de Melo, Cristiane C., Souza, Matheus S., Diniz, Luan F., Carneiro, Renato L., Ellena, Javier

“…Purpose Mechanochemistry is addressed here for the green formation of a 1:1 pharmaceutical cocrystal involving the antifungal prodrug 5-Fluorocytosine (5-FC)…”
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Protonation of inorganic 5-Fluorocytosine salts by Souza, Matheus S., da Silva, Cecília C.P., Almeida, Leonardo R., Diniz, Luan F., Andrade, Marcelo B., Ellena, Javier

“…5-Fluorocytosine (5-FC) has been widely used for the treatment of fungal infections and recently was found to exert an extraordinary antineoplastic activity in…”
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