Search Results - "Dini, Alice"

Multiomics characterization implicates PTK7 in ovarian cancer EMT and cell plasticity and offers strategies for therapeutic intervention by Raivola, Juuli, Dini, Alice, Karvonen, Hanna, Piki, Emilia, Salokas, Kari, Niininen, Wilhelmiina, Kaleva, Laura, Zhang, Kaiyang, Arjama, Mariliina, Gudoityte, Greta, Seashore-Ludlow, Brinton, Varjosalo, Markku, Kallioniemi, Olli, Hautaniemi, Sampsa, Murumägi, Astrid, Ungureanu, Daniela

“…Most patients with ovarian cancer (OC) are diagnosed at a late stage when there are very few therapeutic options and a poor prognosis. This is due to the lack…”
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ROR1-STAT3 signaling contributes to ovarian cancer intra-tumor heterogeneity by Piki, Emilia, Dini, Alice, Raivola, Juuli, Salokas, Kari, Zhang, Kaiyang, Varjosalo, Markku, Pellinen, Teijo, Välimäki, Katja, Veskimäe, Kristina Tabor, Staff, Synnöve, Hautaniemi, Sampsa, Murumägi, Astrid, Ungureanu, Daniela

“…Wnt pathway dysregulation through genetic and non-genetic alterations occurs in multiple cancers, including ovarian cancer (OC). The aberrant expression of the…”
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A multiplex single-cell RNA-Seq pharmacotranscriptomics pipeline for drug discovery by Dini, Alice, Barker, Harlan, Piki, Emilia, Sharma, Subodh, Raivola, Juuli, Murumägi, Astrid, Ungureanu, Daniela

“…The gene-regulatory dynamics governing drug responses in cancer are yet to be fully understood. Here, we report a pipeline capable of producing high-throughput…”
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New insights into the molecular mechanisms of ROR1, ROR2, and PTK7 signaling from the proteomics and pharmacological modulation of ROR1 interactome by Raivola, Juuli, Dini, Alice, Salokas, Kari, Karvonen, Hanna, Niininen, Wilhelmiina, Piki, Emilia, Varjosalo, Markku, Ungureanu, Daniela

“…ROR1, ROR2, and PTK7 are Wnt ligand-binding members of the receptor tyrosine kinase family. Despite their lack of catalytic activity, these receptors regulate…”
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Drug response profiles in patient-derived cancer cells across histological subtypes of ovarian cancer: real-time therapy tailoring for a patient with low-grade serous carcinoma by Murumägi, Astrid, Ungureanu, Daniela, Khan, Suleiman, Arjama, Mariliina, Välimäki, Katja, Ianevski, Aleksandr, Ianevski, Philipp, Bergström, Rebecka, Dini, Alice, Kanerva, Anna, Koivisto-Korander, Riitta, Tapper, Johanna, Lassus, Heini, Loukovaara, Mikko, Mägi, Andrus, Hirasawa, Akira, Aoki, Daisuke, Pietiäinen, Vilja, Pellinen, Teijo, Bützow, Ralf, Aittokallio, Tero, Kallioniemi, Olli

“…Many efforts are underway to develop novel therapies against the aggressive high-grade serous ovarian cancers (HGSOCs), while our understanding of treatment…”
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Molecular and functional profiling of primary normal ovarian cells defines insights into cancer development and drug-responses by Piki, Emilia, Dini, Alice, Rantanen, Frida, Bentz, Franziska, Paavolainen, Lassi, Barker, Harlan, Raivola, Juuli, Hirasawa, Akira, Kallioniemi, Olli, Murumägi, Astrid, Ungureanu, Daniela

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