Search Results - "Dinh, Huy Q."

Monocyte heterogeneity and functions in cancer by Olingy, Claire E., Dinh, Huy Q., Hedrick, Catherine C.

“…Monocytes are innate immune cells of the mononuclear phagocyte system that have emerged as important regulators of cancer development and progression. Our…”
Get full text

DNA methylation loss in late-replicating domains is linked to mitotic cell division by Zhou, Wanding, Dinh, Huy Q., Ramjan, Zachary, Weisenberger, Daniel J., Nicolet, Charles M., Shen, Hui, Laird, Peter W., Berman, Benjamin P.

“…DNA methylation loss occurs frequently in cancer genomes, primarily within lamina-associated, late-replicating regions termed partially methylated domains…”
Get full text

Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry by Winkels, Holger, Ehinger, Erik, Vassallo, Melanie, Buscher, Konrad, Dinh, Huy, Kobiyama, Kouji, Hamers, Anouk A.J, Cochain, Clément, Vafadarnejad, Ehsan, Saliba, Antoine-Emmanuel, Zernecke, Alma, Pramod, Akula Bala, Ghosh, Amlan, Michel, Nathaly Anto, Hoppe, Natalie, Hilgendorf, Ingo, Zirlik, Andreas, Hedrick, Catherine C, Ley, Klaus, Wolf, Dennis

“…RATIONALE:Atherosclerosis is a chronic inflammatory disease that is driven by the interplay of pro- and anti-inflammatory leukocytes in the aorta. Yet, the…”
Get full text

Coexpression of CD71 and CD117 Identifies an Early Unipotent Neutrophil Progenitor Population in Human Bone Marrow by Dinh, Huy Q., Eggert, Tobias, Meyer, Melissa A., Zhu, Yanfang Peipei, Olingy, Claire E., Llewellyn, Ryan, Wu, Runpei, Hedrick, Catherine C.

“…Neutrophils are the most abundant peripheral immune cells and thus, are continually replenished by bone marrow-derived progenitors. Still, how newly identified…”
Get full text

Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas by Zernecke, Alma, Winkels, Holger, Cochain, Clément, Williams, Jesse W., Wolf, Dennis, Soehnlein, Oliver, Robbins, Clint S., Monaco, Claudia, Park, Inhye, McNamara, Coleen A., Binder, Christoph J., Cybulsky, Myron I., Scipione, Corey A., Hedrick, Catherine C., Galkina, Elena V., Kyaw, Tin, Ghosheh, Yanal, Dinh, Huy Q., Ley, Klaus

“…The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9 single-cell RNA sequencing and 2 mass cytometry studies. In a…”
Get full text

Epigenetic Regulation of Repetitive Elements Is Attenuated by Prolonged Heat Stress in Arabidopsis by Pecinka, Ales, Dinh, Huy Q, Baubec, Tuncay, Rosa, Marisa, Lettner, Nicole, Scheid, Ortrun Mittelsten

“…Epigenetic factors determine responses to internal and external stimuli in eukaryotic organisms. Whether and how environmental conditions feed back to the…”
Get full text

The RdDM Pathway Is Required for Basal Heat Tolerance in Arabidopsis by Popova, Olga V., Dinh, Huy Q., Aufsatz, Werner, Jonak, Claudia

“…Heat stress affects epigenetic gene silencing in Arabidopsis. To test for a mechanistic involvement of epige-netic regulation in heat-stress responses, we…”
Get full text

Human Monocyte Heterogeneity as Revealed by High-Dimensional Mass Cytometry by Hamers, Anouk A.J, Dinh, Huy Q, Thomas, Graham D, Marcovecchio, Paola, Blatchley, Amy, Nakao, Catherine S, Kim, Cheryl, McSkimming, Chantel, Taylor, Angela M, Nguyen, Anh T, McNamara, Coleen A, Hedrick, Catherine C

“…OBJECTIVE—Three distinct human monocyte subsets have been identified based on the surface marker expression of CD14 and CD16. We hypothesized that monocytes…”
Get full text

Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma by Lin, De-Chen, Mayakonda, Anand, Dinh, Huy Q, Huang, Pinbo, Lin, Lehang, Liu, Xiaoping, Ding, Ling-Wen, Wang, Jie, Berman, Benjamin P, Song, Er-Wei, Yin, Dong, Koeffler, H Phillip

“…Understanding the intratumoral heterogeneity of hepatocellular carcinoma is instructive for developing personalized therapy and identifying molecular…”
Get full text

Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma by Hao, Jia-Jie, Lin, De-Chen, Dinh, Huy Q, Mayakonda, Anand, Jiang, Yan-Yi, Chang, Chen, Jiang, Ye, Lu, Chen-Chen, Shi, Zhi-Zhou, Xu, Xin, Zhang, Yu, Cai, Yan, Wang, Jin-Wu, Zhan, Qi-Min, Wei, Wen-Qiang, Berman, Benjamin P, Wang, Ming-Rong, Koeffler, H Phillip

“…Ming-Rong Wang, Benjamin Berman and colleagues perform whole-exome sequencing and global methylation profiling on different tumor regions of esophageal…”
Get full text

Alternative splicing and nonsense-mediated decay modulate expression of important regulatory genes in Arabidopsis by Kalyna, Maria, Simpson, Craig G, Syed, Naeem H, Lewandowska, Dominika, Marquez, Yamile, Kusenda, Branislav, Marshall, Jacqueline, Fuller, John, Cardle, Linda, McNicol, Jim, Dinh, Huy Q, Barta, Andrea, Brown, John W S

“…Alternative splicing (AS) coupled to nonsense-mediated decay (NMD) is a post-transcriptional mechanism for regulating gene expression. We have used a…”
Get full text

Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment by Dinh, Huy Q., Pan, Feng, Wang, Geng, Huang, Qing-Feng, Olingy, Claire E., Wu, Zhi-Yong, Wang, Shao-Hong, Xu, Xin, Xu, Xiu-E, He, Jian-Zhong, Yang, Qian, Orsulic, Sandra, Haro, Marcela, Li, Li-Yan, Huang, Guo-Wei, Breunig, Joshua J., Koeffler, H. Phillip, Hedrick, Catherine C., Xu, Li-Yan, Lin, De-Chen, Li, En-Min

“…The tumor microenvironment is a highly complex ecosystem of diverse cell types, which shape cancer biology and impact the responsiveness to therapy. Here, we…”
Get full text

Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells by Bristol, Jillian A, Brand, Joshua, Ohashi, Makoto, Eichelberg, Mark R, Casco, Alejandro, Nelson, Scott E, Hayes, Mitchell, Romero-Masters, James C, Baiu, Dana C, Gumperz, Jenny E, Johannsen, Eric C, Dinh, Huy Q, Kenney, Shannon C

“…Humans are infected with two types of EBV (Type 1 (T1) and Type 2 (T2)) that differ substantially in their EBNA2 and EBNA 3A/B/C latency proteins and have…”
Get full text

Identification of distinct mutational patterns and new driver genes in oesophageal squamous cell carcinomas and adenocarcinomas by Lin, De-Chen, Dinh, Huy Q, Xie, Jian-Jun, Mayakonda, Anand, Silva, Tiago Chedraoui, Jiang, Yan-Yi, Ding, Ling-Wen, He, Jian-Zhong, Xu, Xiu-E, Hao, Jia-Jie, Wang, Ming-Rong, Li, Chunquan, Xu, Li-Yan, Li, En-Min, Berman, Benjamin P, Phillip Koeffler, H

“…Oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC) are distinct cancers in terms of a number of clinical and epidemiological characteristics,…”
Get more information

Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma by Xu, Liang, Chen, Ye, Mayakonda, Anand, Koh, Lynnette, Chong, Yuk Kien, Buckley, Dennis L., Sandanaraj, Edwin, Lim, See Wee, Lin, Ruby Yu-Tong, Ke, Xin-Yu, Huang, Mo-Li, Chen, Jianxiang, Sun, Wendi, Wang, Ling-Zhi, Goh, Boon Cher, Dinh, Huy Q., Kappei, Dennis, Winter, Georg E., Ding, Ling-Wen, Ang, Beng Ti, Berman, Benjamin P., Bradner, James E., Tang, Carol, Koeffler, H. Phillip

“…Competitive BET bromodomain inhibitors (BBIs) targeting BET proteins (BRD2, BRD3, BRD4, and BRDT) show promising preclinical activities against brain cancers…”
Get full text

Single-cell transcriptomics identifies gene expression networks driving differentiation and tumorigenesis in the human fallopian tube by Dinh, Huy Q., Lin, Xianzhi, Abbasi, Forough, Nameki, Robbin, Haro, Marcela, Olingy, Claire E., Chang, Heidi, Hernandez, Lourdes, Gayther, Simon A., Wright, Kelly N., Aspuria, Paul-Joseph, Karlan, Beth Y., Corona, Rosario I., Li, Andrew, Rimel, B.J., Siedhoff, Matthew T., Medeiros, Fabiola, Lawrenson, Kate

“…The human fallopian tube harbors the cell of origin for the majority of high-grade serous “ovarian” cancers (HGSCs), but its cellular composition, particularly…”
Get full text

Frontline Science: Kindlin‐3 is essential for patrolling and phagocytosis functions of nonclassical monocytes during metastatic cancer surveillance by Marcovecchio, Paola M., Zhu, Yanfang Peipei, Hanna, Richard N., Dinh, Huy Q., Tacke, Robert, Wu, Runpei, McArdle, Sara, Reynolds, Sophia, Araujo, Daniel J., Ley, Klaus, Hedrick, Catherine C.

“…Nonclassical monocytes maintain vascular homeostasis by patrolling the vascular endothelium, responding to inflammatory signals, and scavenging cellular…”
Get full text

CD33 Expression on Peripheral Blood Monocytes Predicts Efficacy of Anti-PD-1 Immunotherapy Against Non-Small Cell Lung Cancer by Olingy, Claire, Alimadadi, Ahmad, Araujo, Daniel J, Barry, David, Gutierrez, Norma A, Werbin, Max Hardy, Arriola, Edurne, Patel, Sandip Pravin, Ottensmeier, Christian H, Dinh, Huy Q, Hedrick, Catherine C

“…Non-small cell lung carcinoma (NSCLC) is the leading cause of cancer-related deaths globally. Immune checkpoint blockade (ICB) has transformed cancer medicine,…”
Get full text

A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development by Lawrenson, Kate, Fonseca, Marcos A.S., Liu, Annie Y., Segato Dezem, Felipe, Lee, Janet M., Lin, Xianzhi, Corona, Rosario I., Abbasi, Forough, Vavra, Kevin C., Dinh, Huy Q., Gill, Navjot Kaur, Seo, Ji-Heui, Coetzee, Simon, Lin, Yvonne G., Pejovic, Tanja, Mhawech-Fauceglia, Paulette, Rowat, Amy C., Drapkin, Ronny, Karlan, Beth Y., Hazelett, Dennis J., Freedman, Matthew L., Gayther, Simon A., Noushmehr, Houtan

“…Fallopian tube secretory epithelial cells (FTSECs) are likely the main precursor cell type of high-grade serous ovarian cancers (HGSOCs), but these tumors may…”
Get full text

Nonclassical monocytes potentiate anti-tumoral CD8 + T cell responses in the lungs by Padgett, Lindsey E, Marcovecchio, Paola M, Olingy, Claire E, Araujo, Daniel J, Steel, Kathleen, Dinh, Huy Q, Alimadadi, Ahmad, Zhu, Yanfang Peipei, Meyer, Melissa A, Kiosses, William B, Thomas, Graham D, Hedrick, Catherine C

“…CD8 T cells drive anti-cancer immunity in response to antigen-presenting cells such as dendritic cells and subpopulations of monocytes and macrophages. While…”
Get full text