Search Results - "Dinh, Christine T"

Electrode array-eluted dexamethasone protects against electrode insertion trauma induced hearing and hair cell losses, damage to neural elements, increases in impedance and fibrosis: A dose response study by Bas, Esperanza, Bohorquez, Jorge, Goncalves, Stefania, Perez, Enrique, Dinh, Christine T., Garnham, Carolyn, Hessler, Roland, Eshraghi, Adrien A., Van De Water, Thomas R.

“…We evaluated the effects of dexamethasone base (DXMb) containing electrode arrays in a guinea pig model of cochlear implantation to determine if eluted DXMb…”
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Genomics, Epigenetics, and Hearing Loss in Neurofibromatosis Type 2 by Dinh, Christine T., Nisenbaum, Eric, Chyou, Darius, Misztal, Carly, Yan, Denise, Mittal, Rahul, Young, Juan, Tekin, Mustafa, Telischi, Fred, Fernandez-Valle, Cristina, Liu, Xue-Zhong

“…OBJECTIVES:In this review, we discuss current knowledge about the genetics and epigenetics of vestibular schwannoma (VS) in relation to hearing loss. A…”
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Molecular regulation of auditory hair cell death and approaches to protect sensory receptor cells and/or stimulate repair following acoustic trauma by Dinh, Christine T, Goncalves, Stefania, Bas, Esperanza, Van De Water, Thomas R, Zine, Azel

“…Loss of auditory sensory hair cells (HCs) is the most common cause of hearing loss. This review addresses the signaling pathways that are involved in the…”
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Spiral ganglion cells and macrophages initiate neuro-inflammation and scarring following cochlear implantation by Bas, Esperanza, Goncalves, Stefania, Adams, Michelle, Dinh, Christine T, Bas, Jose M, Van De Water, Thomas R, Eshraghi, Adrien A

“…Conservation of a patient's residual hearing and prevention of fibrous tissue/new bone formation around an electrode array are some of the major challenges in…”
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Preclinical assessment of MEK1/2 inhibitors for neurofibromatosis type 2–associated schwannomas reveals differences in efficacy and drug resistance development by Fuse, Marisa A, Dinh, Christine T, Vitte, Jeremie, Kirkpatrick, Joanna, Mindos, Thomas, Plati, Stephani Klingeman, Young, Juan I, Huang, Jie, Carlstedt, Annemarie, Franco, Maria Clara, Brnjos, Konstantin, Nagamoto, Jackson, Petrilli, Alejandra M, Copik, Alicja J, Soulakova, Julia N, Bracho, Olena, Yan, Denise, Mittal, Rahul, Shen, Rulong, Telischi, Fred F, Morrison, Helen, Giovannini, Marco, Liu, Xue-Zhong, Chang, Long-Sheng, Fernandez-Valle, Cristina

“…Abstract Background Neurofibromatosis type 2 (NF2) is a genetic tumor-predisposition disorder caused by NF2/merlin tumor suppressor gene inactivation. The…”
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Tumor-Associated Macrophages in Vestibular Schwannoma and Relationship to Hearing by Nisenbaum, Eric, Misztal, Carly, Szczupak, Mikhaylo, Thielhelm, Torin, Peña, Stefanie, Mei, Christine, Goncalves, Stefania, Bracho, Olena, Ma, Ruixuan, Ivan, Michael E., Morcos, Jacques, Telischi, Fred, Liu, Xue-Zhong, Fernandez-Valle, Cristina, Dinh, Christine T.

“…Objective (1) Characterize the distribution of M1 and M2 macrophages in vestibular schwannomas by hearing status. (2) Develop assays to assess monocyte…”
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N95 vs Half-face Respirator Wear in Surgical Trainees: Physiologic and Psychological Effects of Prolonged Use by Cohen, Erin R., Peña, Stefanie, Misztal, Carly, Iglesias, Thomas, Alejandro, Mantero, Dinh, Christine T., Holt, Gregory, Thomas, Giovana R.

“…Objectives As specialists of the upper airway, otolaryngologists are at high risk for COVID-19 transmission. N95 and half-face respirator (HFR) masks are…”
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Updates on Tumor Biology in Vestibular Schwannoma by Nourbakhsh, Aida, Dinh, Christine T.

“…Vestibular schwannomas (VSs) are benign tumors that develop after biallelic inactivation of the neurofibromatosis type 2 (NF2) gene that encodes the tumor…”
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Mechanisms of hearing loss from trauma and inflammation: otoprotective therapies from the laboratory to the clinic by van de Water, Thomas R., Dinh, Christine T., Vivero, Richard, Hoosien, Gia, Eshraghi, Adrien A., Balkany, Thomas J.

“…This article reviews a series of in vitro and in vivo studies that examined the otoprotective efficacy of locally delivered dexamethasone and explored the…”
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Speech Discrimination Outcomes in Adult Cochlear Implant Recipients by Primary Language and Bilingual Hispanic Patients by Velandia, Sandra, Martinez, Diane, Peña, Stefanie, Misztal, Carly, Goncalves, Stefania, Ma, Ruixuan, Angeli, Simon, Telischi, Fred, Holcomb, Meredith, Dinh, Christine T.

“…Objective Compare cochlear implant (CI) outcomes in English speakers, Spanish speakers, and bilingual Hispanics. Study Design Retrospective review. Setting…”
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Improved intracochlear biopolymeric drug delivery system: an in vivo study by Goncalves, Stefania, Thielhelm, Torin, Pawley, Devon, Bas, Esperanza, Dikici, Emre, Deo, Sapna K., Dinh, Christine T., Daunert, Sylvia, Telischi, Fred

“…The delivery of drugs into the inner ear is a challenging field of study due to the complex cochlear anatomy and physiology. The creation of an intracochlear…”
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Haller's Ansa: An Unrecognized Route of Facial Movement After Skull Base Surgery by Thielhelm, Torin P., Dinh, Christine T., Sargi, Zoukaa, Ivan, Michael E., Ein, Liliana

“…A direct communication between the glossopharyngeal and facial nerves known as Haller's ansa exists in a minority of patients. Clinical manifestations of this…”
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Brigatinib in NF2-Related Schwannomatosis with Progressive Tumors by Plotkin, Scott R., Yohay, Kaleb H., Nghiemphu, Phioanh L., Dinh, Christine T., Babovic-Vuksanovic, Dusica, Merker, Vanessa L., Bakker, Annette, Fell, Geoffrey, Trippa, Lorenzo, Blakeley, Jaishri O.

“…Brigatinib produced responses in 23% of all tumors in patients with NF2 -related tumors (schwannomas, meningiomas, and ependymomas), with hearing improvement…”
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Comparison of Speech Test Outcomes After Cochlear Implantation in Patients With and Without Asymmetric Hearing Loss by Misztal, Carly, Peña, Stefanie, Martinez, Diane, Velandia, Sandra, Goncalves, Stefania, Ma, Ruixuan, Holcomb, Meredith, Angeli, Simon, Telischi, Fred, Dinh, Christine T.

“…Determine whether asymmetric hearing loss (AHL) affects postoperative speech outcomes in cochlear implant (CI) patients. Retrospective cohort study. Tertiary…”
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Recent advancements in understanding the role of epigenetics in the auditory system by Mittal, Rahul, Bencie, Nicole, Liu, George, Eshraghi, Nicolas, Nisenbaum, Eric, Blanton, Susan H., Yan, Denise, Mittal, Jeenu, Dinh, Christine T., Young, Juan I., Gong, Feng, Liu, Xue Zhong

“…Sensorineural deafness in mammals is most commonly caused by damage to inner ear sensory epithelia, or hair cells, and can be attributed to genetic and…”
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Cotargeting Phosphoinositide 3-Kinase and Focal Adhesion Kinase Pathways Inhibits Proliferation of NF2 Schwannoma Cells by Hardin, Haley M, Dinh, Christine T, Huegel, Julianne, Petrilli, Alejandra M, Bracho, Olena, Allaf, Abdulrahman M, Karajannis, Matthias A, Griswold, Anthony J, Ivan, Michael E, Morcos, Jacques, Gultekin, Sakir H, Telischi, Fred F, Liu, Xue Zhong, Fernandez-Valle, Cristina

“…Neurofibromatosis Type 2 (NF2) is a tumor predisposition syndrome caused by germline inactivating mutations in the NF2 gene encoding the merlin tumor…”
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Laminin-coated electrodes improve cochlear implant function and post-insertion neuronal survival by Bas, Esperanza, Anwar, Mir R., Goncalves, Stefania, Dinh, Christine T., Bracho, Olena R., Chiossone, Juan A., Van De Water, Thomas R.

“…The benefits of Cochlear implant (CI) technology depend among other factors on the proximity of the electrode array to the spiral ganglion neurons. Laminin, a…”
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CUDC907, a dual phosphoinositide-3 kinase/histone deacetylase inhibitor, promotes apoptosis of NF2 Schwannoma cells by Huegel, Julianne, Dinh, Christine T, Martinelli, Maria, Bracho, Olena, Rosario, Rosa, Hardin, Haley, Estivill, Michael, Griswold, Anthony, Gultekin, Sakir, Liu, Xue-Zhong, Fernandez-Valle, Cristina

“…Neurofibromatosis Type 2 (NF2) is a rare tumor disorder caused by pathogenic variants of the merlin tumor suppressor encoded by . Patients develop vestibular…”
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Effect of AR42 in Primary Vestibular Schwannoma Cells and a Xenograft Model of Vestibular Schwannoma by Misztal, Carly, Bracho, Olena, Bas, Esperanza, Estivill, Michael, Ivan, Michael E., Morcos, Jacques, Bhatia, Rita, Telischi, Fred, Liu, Xue-Zhong, Gultekin, Sakir H., Fernandez-Valle, Cristina, Dinh, Christine T.

“…AR42, a histone deacetylase (HDAC) inhibitor, reduces viability of primary vestibular schwannoma (VS) cells and delays tumor progression and hearing loss (HL)…”
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Redefining Perineural Invasion in Head and Neck Cutaneous Squamous Cell Carcinoma by Cohen, Erin R., Misztal, Carly, Dable, Cortney, Gomez-Fernandez, Carmen, Bhatia, Rita G., Roth, Patrick, Ma, Ruixuan, Trosman, Samuel, Green, Carlos, Nicolli, Elizabeth, Dinh, Christine T., Sargi, Zoukaa B.

“…Objective Perineural invasion (PNI) negatively affects disease-specific survival in patients with head and neck cutaneous squamous cell carcinoma (HNcSCC). We…”
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