Search Results - "Dinger, Marcel E."

The specificity of long noncoding RNA expression by Gloss, Brian S., Dinger, Marcel E.

“…Over the last decade, long noncoding RNAs (lncRNAs) have emerged as a fundamental molecular class whose members play pivotal roles in the regulation of the…”
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Long noncoding RNAs in cancer: mechanisms of action and technological advancements by Bartonicek, Nenad, Maag, Jesper L V, Dinger, Marcel E

“…The previous decade has seen long non-coding RNAs (lncRNAs) rise from obscurity to being defined as a category of genetic elements, leaving its mark on the…”
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lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs by Quek, Xiu Cheng, Thomson, Daniel W, Maag, Jesper L V, Bartonicek, Nenad, Signal, Bethany, Clark, Michael B, Gloss, Brian S, Dinger, Marcel E

“…Despite the prevalence of long noncoding RNA (lncRNA) genes in eukaryotic genomes, only a small proportion have been examined for biological function…”
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Realizing the significance of noncoding functionality in clinical genomics by Gloss, Brian S., Dinger, Marcel E.

“…Clinical genomics promises unprecedented precision in understanding the genetic basis of disease. Understanding the impact of variation across the genome is…”
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Human Mitochondrial Transcriptome by Mercer, Tim R, Neph, Shane, Dinger, Marcel E, Crawford, Joanna, Smith, Martin A, Shearwood, Anne-Marie J, Haugen, Eric, Bracken, Cameron P, Rackham, Oliver, Stamatoyannopoulos, John A, Filipovska, Aleksandra, Mattick, John S

“…The human mitochondrial genome comprises a distinct genetic system transcribed as precursor polycistronic transcripts that are subsequently cleaved to generate…”
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Benchmarking of RNA-sequencing analysis workflows using whole-transcriptome RT-qPCR expression data by Everaert, Celine, Luypaert, Manuel, Maag, Jesper L. V., Cheng, Quek Xiu, Dinger, Marcel E., Hellemans, Jan, Mestdagh, Pieter

“…RNA-sequencing has become the gold standard for whole-transcriptome gene expression quantification. Multiple algorithms have been developed to derive gene…”
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Genome-wide analysis of long noncoding RNA stability by Clark, Michael B, Johnston, Rebecca L, Inostroza-Ponta, Mario, Fox, Archa H, Fortini, Ellen, Moscato, Pablo, Dinger, Marcel E, Mattick, John S

“…Transcriptomic analyses have identified tens of thousands of intergenic, intronic, and cis-antisense long noncoding RNAs (lncRNAs) that are expressed from…”
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CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity by Suan, Dan, Kräutler, Nike J., Maag, Jesper L.V., Butt, Danyal, Bourne, Katherine, Hermes, Jana R., Avery, Danielle T., Young, Clara, Statham, Aaron, Elliott, Michael, Dinger, Marcel E., Basten, Antony, Tangye, Stuart G., Brink, Robert

“…Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral…”
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The Melanoma-Upregulated Long Noncoding RNA SPRY4-IT1 Modulates Apoptosis and Invasion by KHAITAN, Divya, DINGER, Marcel E, MAZAR, Joseph, CRAWFORD, Joanna, SMITH, Martin A, MATTICK, John S, PERERA, Ranjan J

“…The identification of cancer-associated long noncoding RNAs (lncRNAs) and the investigation of their molecular and biological functions are important to…”
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Index suffix-prefix overlaps by (w, k)-minimizer to generate long contigs for reads compression by Liu, Yuansheng, Yu, Zuguo, Dinger, Marcel E, Li, Jinyan

“…Advanced high-throughput sequencing technologies have produced massive amount of reads data, and algorithms have been specially designed to contract the size…”
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The regulatory role of long noncoding RNAs in cancer by Tang, Ying, Cheung, Belamy B, Atmadibrata, Bernard, Marshall, Glenn M, Dinger, Marcel E, Liu, Pei Y, Liu, Tao

“…Abstract With the advances in genomic analysis technologies, especially next-generation RNA sequencing, a large number of new transcripts have been discovered,…”
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Eukaryotic Genome as an RNA Machine by Amaral, Paulo P, Dinger, Marcel E, Mercer, Tim R, Mattick, John S

“…The past few years have revealed that the genomes of all studied eukaryotes are almost entirely transcribed, generating an enormous number of…”
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Dysregulation of non-coding RNAs in Rheumatoid arthritis by Taheri, Mohammad, Eghtedarian, Reyhane, Dinger, Marcel E., Ghafouri-Fard, Soudeh

“…Rheumatoid arthritis (RA) is a chronic inflammatory disorder that is associated with both genetic and environmental factors. Dysregulation of the immune…”
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Genome-wide discovery of human splicing branchpoints by Mercer, Tim R, Clark, Michael B, Andersen, Stacey B, Brunck, Marion E, Haerty, Wilfried, Crawford, Joanna, Taft, Ryan J, Nielsen, Lars K, Dinger, Marcel E, Mattick, John S

“…During the splicing reaction, the 5' intron end is joined to the branchpoint nucleotide, selecting the next exon to incorporate into the mature RNA and forming…”
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Seave: a comprehensive web platform for storing and interrogating human genomic variation by Gayevskiy, Velimir, Roscioli, Tony, Dinger, Marcel E, Cowley, Mark J

“…Abstract Motivation Genome sequencing has had a remarkable impact on our ability to study the effects of human genetic variation, however, variant…”
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Specific expression of long noncoding RNAs in the mouse brain by Mercer, Tim R, Dinger, Marcel E, Sunkin, Susan M, Mehler, Mark F, Mattick, John S

“…A major proportion of the mammalian transcriptome comprises long RNAs that have little or no protein-coding capacity (ncRNAs). Only a handful of such…”
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Whole-exome sequencing reanalysis at 12 months boosts diagnosis and is cost-effective when applied early in Mendelian disorders by Ewans, Lisa J., Schofield, Deborah, Shrestha, Rupendra, Zhu, Ying, Gayevskiy, Velimir, Ying, Kevin, Walsh, Corrina, Lee, Eric, Kirk, Edwin P, Colley, Alison, Ellaway, Carolyn, Turner, Anne, Mowat, David, Worgan, Lisa, Freckmann, Mary-Louise, Lipke, Michelle, Sachdev, Rani, Miller, David, Field, Michael, Dinger, Marcel E., Buckley, Michael F., Cowley, Mark J, Roscioli, Tony

“…Whole-exome sequencing (WES) has revolutionized Mendelian diagnostics, however, there is no consensus on the timing of data review in undiagnosed individuals…”
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Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation by Mercer, Tim R, Qureshi, Irfan A, Gokhan, Solen, Dinger, Marcel E, Li, Guangyu, Mattick, John S, Mehler, Mark F

“…Long non-protein-coding RNAs (ncRNAs) are emerging as important regulators of cellular differentiation and are widely expressed in the brain. Here we show that…”
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Machine learning annotation of human branchpoints by Signal, Bethany, Gloss, Brian S, Dinger, Marcel E, Mercer, Tim R

“…Abstract Motivation The branchpoint element is required for the first lariat-forming reaction in splicing. However current catalogues of human branchpoints…”
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Emerging role of circular RNAs in the pathobiology of lung cancer by Ghafouri-Fard, Soudeh, Dinger, Marcel E., Maleki, Parichehr, Taheri, Mohammad, Hajiesmaeili, Mohammadreza

“…Lung cancer is among the leading causes of cancer mortality and incidence in both sexes. Different classes of transcripts have been proposed as molecular…”
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