Search Results - "Dingens, Adam"

Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding by Starr, Tyler N., Greaney, Allison J., Hilton, Sarah K., Ellis, Daniel, Crawford, Katharine H.D., Dingens, Adam S., Navarro, Mary Jane, Bowen, John E., Tortorici, M. Alejandra, Walls, Alexandra C., King, Neil P., Veesler, David, Bloom, Jesse D.

“…The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral attachment to ACE2 receptor and is a major determinant of host range and…”
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Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays by Crawford, Katharine H D, Eguia, Rachel, Dingens, Adam S, Loes, Andrea N, Malone, Keara D, Wolf, Caitlin R, Chu, Helen Y, Tortorici, M Alejandra, Veesler, David, Murphy, Michael, Pettie, Deleah, King, Neil P, Balazs, Alejandro B, Bloom, Jesse D

“…SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera…”
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Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016 by Starr, Tyler N., Greaney, Allison J., Dingens, Adam S., Bloom, Jesse D.

“…Monoclonal antibodies and antibody cocktails are a promising therapeutic and prophylaxis for coronavirus disease 2019 (COVID-19). However, ongoing evolution of…”
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Prospective mapping of viral mutations that escape antibodies used to treat COVID-19 by Starr, Tyler N, Greaney, Allison J, Addetia, Amin, Hannon, William W, Choudhary, Manish C, Dingens, Adam S, Li, Jonathan Z, Bloom, Jesse D

“…Antibodies are a potential therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the risk of the virus evolving to escape them remains…”
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Dynamics of Neutralizing Antibody Titers in the Months After Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Crawford, Katharine H D, Dingens, Adam S, Eguia, Rachel, Wolf, Caitlin R, Wilcox, Naomi, Logue, Jennifer K, Shuey, Kiel, Casto, Amanda M, Fiala, Brooke, Wrenn, Samuel, Pettie, Deleah, King, Neil P, Greninger, Alexander L, Chu, Helen Y, Bloom, Jesse D

“…Abstract Most individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop neutralizing antibodies that target the viral…”
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Experimental Estimation of the Effects of All Amino-Acid Mutations to HIV's Envelope Protein on Viral Replication in Cell Culture by Haddox, Hugh K, Dingens, Adam S, Bloom, Jesse D

“…HIV is notorious for its capacity to evade immunity and anti-viral drugs through rapid sequence evolution. Knowledge of the functional effects of mutations to…”
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An Antigenic Atlas of HIV-1 Escape from Broadly Neutralizing Antibodies Distinguishes Functional and Structural Epitopes by Dingens, Adam S., Arenz, Dana, Weight, Haidyn, Overbaugh, Julie, Bloom, Jesse D.

“…Anti-HIV broadly neutralizing antibodies (bnAbs) have revealed vaccine targets on the virus’s envelope (Env) protein and are themselves promising…”
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Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition by Greaney, Allison J., Starr, Tyler N., Gilchuk, Pavlo, Zost, Seth J., Binshtein, Elad, Loes, Andrea N., Hilton, Sarah K., Huddleston, John, Eguia, Rachel, Crawford, Katharine H.D., Dingens, Adam S., Nargi, Rachel S., Sutton, Rachel E., Suryadevara, Naveenchandra, Rothlauf, Paul W., Liu, Zhuoming, Whelan, Sean P.J., Carnahan, Robert H., Crowe, James E., Bloom, Jesse D.

“…Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being developed as therapeutics and are a major contributor to neutralizing…”
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Comprehensive Mapping of HIV-1 Escape from a Broadly Neutralizing Antibody by Dingens, Adam S., Haddox, Hugh K., Overbaugh, Julie, Bloom, Jesse D.

“…Precisely defining how viral mutations affect HIV’s sensitivity to antibodies is vital to develop and evaluate vaccines and antibody immunotherapeutics…”
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Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody by Schommers, Philipp, Gruell, Henning, Abernathy, Morgan E., Tran, My-Kim, Dingens, Adam S., Gristick, Harry B., Barnes, Christopher O., Schoofs, Till, Schlotz, Maike, Vanshylla, Kanika, Kreer, Christoph, Weiland, Daniela, Holtick, Udo, Scheid, Christof, Valter, Markus M., van Gils, Marit J., Sanders, Rogier W., Vehreschild, Jörg J., Cornely, Oliver A., Lehmann, Clara, Fätkenheuer, Gerd, Seaman, Michael S., Bloom, Jesse D., Bjorkman, Pamela J., Klein, Florian

“…Broadly neutralizing antibodies (bNAbs) represent a promising approach to prevent and treat HIV-1 infection. However, viral escape through mutation of the…”
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Mapping mutational effects along the evolutionary landscape of HIV envelope by Haddox, Hugh K, Dingens, Adam S, Hilton, Sarah K, Overbaugh, Julie, Bloom, Jesse D

“…The immediate evolutionary space accessible to HIV is largely determined by how single amino acid mutations affect fitness. These mutational effects can shift…”
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Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV by Dingens, Adam S, Acharya, Priyamvada, Haddox, Hugh K, Rawi, Reda, Xu, Kai, Chuang, Gwo-Yu, Wei, Hui, Zhang, Baoshan, Mascola, John R, Carragher, Bridget, Potter, Clinton S, Overbaugh, Julie, Kwong, Peter D, Bloom, Jesse D

“…Eliciting broadly neutralizing antibodies (bnAbs) targeting envelope (Env) is a major goal of HIV vaccine development, but cross-clade breadth from…”
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Serological identification of SARS-CoV-2 infections among children visiting a hospital during the initial Seattle outbreak by Dingens, Adam S., Crawford, Katharine H. D., Adler, Amanda, Steele, Sarah L., Lacombe, Kirsten, Eguia, Rachel, Amanat, Fatima, Walls, Alexandra C., Wolf, Caitlin R., Murphy, Michael, Pettie, Deleah, Carter, Lauren, Qin, Xuan, King, Neil P., Veesler, David, Krammer, Florian, Dickerson, Jane A., Chu, Helen Y., Englund, Janet A., Bloom, Jesse D.

“…Children are strikingly underrepresented in COVID-19 case counts. In the United States, children represent 22% of the population but only 1.7% of confirmed…”
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Bacterial vaginosis and adverse outcomes among full-term infants: a cohort study by Dingens, Adam S, Fairfortune, Tessa S, Reed, Susan, Mitchell, Caroline

“…Bacterial vaginosis (BV) during pregnancy is a well-established risk factor for preterm birth and other preterm pregnancy complications. Little is known about…”
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Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features by Magaret, Craig A, Benkeser, David C, Williamson, Brian D, Borate, Bhavesh R, Carpp, Lindsay N, Georgiev, Ivelin S, Setliff, Ian, Dingens, Adam S, Simon, Noah, Carone, Marco, Simpkins, Christopher, Montefiori, David, Alter, Galit, Yu, Wen-Han, Juraska, Michal, Edlefsen, Paul T, Karuna, Shelly, Mgodi, Nyaradzo M, Edugupanti, Srilatha, Gilbert, Peter B

“…The broadly neutralizing antibody (bnAb) VRC01 is being evaluated for its efficacy to prevent HIV-1 infection in the Antibody Mediated Prevention (AMP) trials…”
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Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization by Kong, Rui, Duan, Hongying, Sheng, Zizhang, Xu, Kai, Acharya, Priyamvada, Chen, Xuejun, Cheng, Cheng, Dingens, Adam S., Gorman, Jason, Sastry, Mallika, Shen, Chen-Hsiang, Zhang, Baoshan, Zhou, Tongqing, Chuang, Gwo-Yu, Chao, Cara W., Gu, Ying, Jafari, Alexander J., Louder, Mark K., O’Dell, Sijy, Rowshan, Ariana P., Viox, Elise G., Wang, Yiran, Choi, Chang W., Corcoran, Martin M., Corrigan, Angela R., Dandey, Venkata P., Eng, Edward T., Geng, Hui, Foulds, Kathryn E., Guo, Yicheng, Kwon, Young D., Lin, Bob, Liu, Kevin, Mason, Rosemarie D., Nason, Martha C., Ohr, Tiffany Y., Ou, Li, Rawi, Reda, Sarfo, Edward K., Schön, Arne, Todd, John P., Wang, Shuishu, Wei, Hui, Wu, Winston, Mullikin, James C., Bailer, Robert T., Doria-Rose, Nicole A., Karlsson Hedestam, Gunilla B., Scorpio, Diana G., Overbaugh, Julie, Bloom, Jesse D., Carragher, Bridget, Potter, Clinton S., Shapiro, Lawrence, Kwong, Peter D., Mascola, John R.

“…The vaccine-mediated elicitation of antibodies (Abs) capable of neutralizing diverse HIV-1 strains has been a long-standing goal. To understand how broadly…”
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Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning by Radford, Caelan E., Schommers, Philipp, Gieselmann, Lutz, Crawford, Katharine H.D., Dadonaite, Bernadeta, Yu, Timothy C., Dingens, Adam S., Overbaugh, Julie, Klein, Florian, Bloom, Jesse D.

“…Understanding the specificities of human serum antibodies that broadly neutralize HIV can inform prevention and treatment strategies. Here, we describe a deep…”
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Cooperation between distinct viral variants promotes growth of H3N2 influenza in cell culture by Xue, Katherine S, Hooper, Kathryn A, Ollodart, Anja R, Dingens, Adam S, Bloom, Jesse D

“…RNA viruses rapidly diversify into quasispecies of related genotypes. This genetic diversity has long been known to facilitate adaptation, but recent studies…”
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Massively Parallel Profiling of HIV-1 Resistance to the Fusion Inhibitor Enfuvirtide by Dingens, Adam S, Arenz, Dana, Overbaugh, Julie, Bloom, Jesse D

“…Identifying drug resistance mutations is important for the clinical use of antivirals and can help define both a drug's mechanism of action and the mechanistic…”
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Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization by Glögl, Matthias, Friedrich, Nikolas, Cerutti, Gabriele, Lemmin, Thomas, Kwon, Young D., Gorman, Jason, Maliqi, Liridona, Mittl, Peer R. E., Hesselman, Maria C., Schmidt, Daniel, Weber, Jacqueline, Foulkes, Caio, Dingens, Adam S., Bylund, Tatsiana, Olia, Adam S., Verardi, Raffaello, Reinberg, Thomas, Baumann, Nicolas S., Rusert, Peter, Dreier, Birgit, Shapiro, Lawrence, Kwong, Peter D., Plückthun, Andreas, Trkola, Alexandra

“…The third variable (V3) loop on the human immunodeficiency virus 1 (HIV-1) envelope glycoprotein trimer is indispensable for virus cell entry. Conformational…”
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